DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Su(dx) and Nedd4

DIOPT Version :9

Sequence 1:	NP_001259898.1	Gene:	Su(dx) / 33379	FlyBaseID:	FBgn0003557	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	XP_017450968.1	Gene:	Nedd4 / 25489	RGDID:	3157	Length:	1223	Species:	Rattus norvegicus

Alignment Length:	1089	Identity:	351/1089 - (32%)
Similarity:	497/1089 - (45%)	Gaps:	273/1089 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 NGLPAGAASGGMEAGQTVNGAGSASPTPTS--SSGAGASG---SANQGYHQLSVTIEEASLRN-- 62
            |..||...|.|  |.||.:.. ..|||.|:  ..|.|..|   :|..|.....||.....:|:
  Rat   257 NTPPASPTSRG--AYQTSHQL-VVSPTETAHHEDGTGTRGFLSTAVSGLRLSKVTCTPGEVRDVR 318

  Fly    63 ----NGFLKPNPYVELLIDSKSKRKTDLVK--------NSYLPKWNEEFTVLITP-----NSTLH 110
                .|.|:.    :::|.....::|...|        :.:|.:.|:..:....|     :..|.
  Rat   319 PLHAKGSLQK----KIVISDNRPKQTVCEKLPERFSCVSVHLTQQNQTASDCANPCVGRTSERLE 379

  Fly   111 FKV---LDHSSFRKDAMLGERIINLAHILQHYNGRCEFLELTIDLFVTSKSDNRQTKSGELVAIL 172
            .::   |||      .||.:|.           ..|        |..|..:|:.....|||.
  Rat   380 LQLQSDLDH------GMLTQRA-----------SPC--------LPTTPDTDSHVNIRGELE--- 416

  Fly   173 NGLKLDMSKLQIQPVAGQQNGNPPVQ------AVNPSVVSDAAAGRSCMIYGGVRARMRLRSSSG 231
                        :|.:.:..|...:|      ...|:|...::...||.  .|..:::.::.:||
  Rat   417 ------------RPNSQRSRGRAALQRSVSLGGTYPNVSCLSSLKHSCS--KGGPSQLLIKFASG 467

  Fly   232 NSNGGETRSPLPNGGGDHRRSTQAPPVWEQQQQQSQNQQQPLRMVNGSGAAVPQTAPYPQQPPAP 296
            |.  |:..|                 .|  :::...|:...:|..............||.....|
  Rat   468 ND--GKVDS-----------------FW--RERDLTNELSGVRKTRDDFLGQVDVPLYPLPTENP 511

  Fly   297 ALARPLTQVYGALPENTQPAAV---------YLPAGGGAAVGPPGVAGPPIEQPGVGLPVSQSTD 352
            .:.||.|.....|...:..:.|         |||..|                          :|
  Rat   512 RMERPYTFKDFVLHPRSHKSRVKGYLRLKMTYLPKNG--------------------------SD 550

  Fly   353 PQLQTQPADDEPLPAGWEIRLDQYGRRYYVDHNTRSTYWEKPTPLPPGWEIRKDGRGRVYYVDHN 417
            .:...|..:.||   ||.: |||.....::.|.      .:|:|||||||.|:|..||.|||:|.
  Rat   551 DENADQAEELEP---GWVV-LDQPDAATHLQHP------PEPSPLPPGWEERQDVLGRTYYVNHE 605

  Fly   418 TRKTTWQRPNSE-----------RLMHFQHWQGQRAHV----------------------VSQGN 449
            :|.|.|:||:.|           :|      |.|||..                      :.:.:
  Rat   606 SRTTQWKRPSPEDDLTDDENGDIQL------QAQRAFTTRRQISEDVDGPDNHESPENWEIVRED 664

  Fly   450 QRYLYSQQ--QQQPT-----------------------AVTAQVTQDDEDALG------------ 477
            :..:||.|  |..|:                       |.:..||..:..:.|
  Rat   665 ENTMYSGQAVQSPPSGHPDVQVRLAEELDTRLTMYGNPATSQPVTSSNHSSRGGSSQTCIFEEQP 729

  Fly   478 ----------PLPDGWEKKIQSDNRVYFVNHKNRTTQWEDPRTQGQEVSLI------------NE 520
                      .||.|||:|.....|.|:|:|.::||.|..|..|....|.|            |:
  Rat   730 TLPVLLPTSSGLPPGWEEKQDDRGRSYYVDHNSKTTTWSKPTMQDDPRSKIPAHLRGKTPVDSND 794

  Fly   521 -GPLPPGWEIRYTAAGERFFVDHNTRRTTFEDPR--------PGAPKGAKGVYGVPRAYERSFRW 576
             ||||||||.|....|..||::||.::|.:||||        |..|            |.|.::.
  Rat   795 LGPLPPGWEERTHTDGRVFFINHNIKKTQWEDPRMQNVAITGPAVP------------YSRDYKR 847

  Fly   577 KLSQF-RYLCQSNALPSHIKITVTRQTLFEDSYHQIMRLPAYE-LRRRLYIIFRGEEGLDYGGVS 639
            |...| |.|.:...:|:..::.:.|..:.||||.:||.:...: |:.||:|.|.||:|||||||:
  Rat   848 KYEFFRRKLKKQTDIPNKFEMKLRRANILEDSYRRIMGVKRADFLKARLWIEFDGEKGLDYGGVA 912

  Fly   640 REWFFLLSHEVLNPMYCLFEYANKNNYSLQINPAS-YVNPDHLQYFKFIGRFIAMALYHGRFIYS 703
            ||||||:|.|:.||.|.||||:..:||:|||||.| ..|.|||.|||||||...||:|||:.:..
  Rat   913 REWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDG 977

  Fly   704 GFTMPFYKRMLNKKLTIKDIETIDPEFYNSLIWVKDNNIDECGLELWFSVDFEVLGQIIHHELKE 768
            .|..||||.||.|.:|:.|:|::|.|:|:||.|:.:|  |...|:|.|.:|.|:.||...||||.
  Rat   978 FFIRPFYKMMLQKLITLHDMESVDSEYYSSLRWILEN--DPTELDLRFIIDEELFGQTHQHELKT 1040

  Fly   769 NGEKERVTEENKEEYITLMTEWRMTRGIEQQTKTFLEGFNEVVPLEWLKYFDERELELILCGMQD 833
            .|.:..||.:||:|||.|:.:||....|::|...|.|||.|::|.:.:|.|||.||||::||:.|
  Rat  1041 GGSEVVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGD 1105

  Fly   834 VDVEDWQRNTIYRH-YNRNSKQVVWFWQFVRETDNEKRARLLQFVTGTCRVPVGGFAELMGSNGP 897
            |||.||:.:|.|:: |:.|.:.:.|||:.|...|:|||.|||||||||.|||:.|||||.|||||
  Rat  1106 VDVNDWREHTKYKNGYSLNHQVIHWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAELYGSNGP 1170

  Fly   898 QRFCIEKVGKETWLPRSHTCFNRLDLPPYKSYDQLVEKLTFAIEETEGF 946
            |.|.:|:.|....|||:||||||||||||:|:|:|.:||..|||.|:||
  Rat  1171 QSFTVEQWGTPDKLPRAHTCFNRLDLPPYESFDELWDKLQMAIENTQGF 1219

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(dx)	NP_001259898.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988	25/146 (17%)
		WW	364..396	CDD:197736	8/31 (26%)
		WW	397..426	CDD:278809	17/28 (61%)
		WW	478..509	CDD:197736	13/30 (43%)
		WW	522..554	CDD:197736	18/39 (46%)
		HECTc	594..946	CDD:238033	187/354 (53%)
		HECTc	620..946	CDD:214523	179/327 (55%)
Nedd4	XP_017450968.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100256
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810