DRSC/TRiP Functional Genomics Resources

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Protein Alignment Su(dx) and Magi3

DIOPT Version :9

Sequence 1:NP_001259898.1 Gene:Su(dx) / 33379 FlyBaseID:FBgn0003557 Length:949 Species:Drosophila melanogaster
Sequence 2:NP_620784.3 Gene:Magi3 / 245903 RGDID:621362 Length:1470 Species:Rattus norvegicus


Alignment Length:828 Identity:168/828 - (20%)
Similarity:258/828 - (31%) Gaps:326/828 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly   288 PYPQQPPAPALARPLTQVY------------------------GALPENTQPAAVYLPAGGGAAV 328
            |.|...|:|....|:.||.                        .:|||..:........|.|:  
  Rat   193 PKPPAEPSPFQPDPVDQVLFDNEFDTESQRKRTTSVSKMERMDSSLPEEEEDEDKEAVNGSGS-- 255

  Fly   329 GPPGVAGPPIEQPGVGLPVSQSTDPQLQTQPA----------------DD--EPLPAGWEIRLDQ 375
                     :|...:.   |:|:|..::|.|:                |:  ||||..||:....
  Rat   256 ---------METREMH---SESSDCWMKTVPSYNQTNRSMDFRNYMMRDENLEPLPKNWEMAYTD 308

  Fly   376 YGRRYYVDHNTRSTYWEKPT--------------PLPPGWEIRKDGRGRVYYVDHNTRKTTWQRP 426
            .|..|::||||::|.|..|.              .||.|||..:|.:...|||||..:||.::.|
  Rat   309 TGTIYFIDHNTKTTTWLDPRLCKKAKAPEDCEDGELPYGWEKIEDPQYGTYYVDHLNQKTQFENP 373

  Fly   427 NSERLMHFQHWQGQRAHVVSQGNQRYLYSQQQQQPTAVTAQVTQDDEDALGPLPDGWEKK----- 486
            ..|.....|..|.: .|......:|              |..|:|.....|.|.....||     
  Rat   374 VEEAKRKKQIGQAE-THSAKTDVER--------------AHFTRDPSQLKGVLVRASLKKSTMGF 423

  Fly   487 ----IQSDNRVYFVNHKNRTTQWEDPRTQGQEVSLINEGPLPPGWEIRYTAAGERFFVDHNTRRT 547
                |..|....|:..||  ...:.|..|        :|.:.||..|          ||.|    
  Rat   424 GFTIIGGDRPDEFLQVKN--VLKDGPAAQ--------DGKMAPGDVI----------VDIN---- 464

  Fly   548 TFEDPRPGAPKGAKGVYGVPRA-YERSFRW-KLSQF--RYLCQSNALPSHIKITVTRQTLFEDSY 608
                        ...|.|...| ..:.|:. .::|:  ..||:..|||             :||.
  Rat   465 ------------GNCVLGHTHADVVQMFQLVPVNQYVNLTLCRGYALP-------------DDSE 504

  Fly   609 HQIMRLPAYELRRRLYIIFRGEE------------GLDYGGVSREWFFLLSHEVLN-PMYCLFEY 660
            ..::.:.|.........:.:||.            .||..|.|.:   |||.:.|| |     ..
  Rat   505 DPVVDIVAATPVINGQSLAKGEACMSTQDFKLGAMVLDQNGKSGK---LLSSDHLNGP-----SD 561

  Fly   661 ANKNNYSLQINPASYVNPDHLQYFKFIGRFIAMALYHGRFIYSGFTMPFYKRMLNKKLTIKDIET 725
            :|:...||..:.:|  .|:.:                        |:|..|........|.|..|
  Rat   562 SNEQRASLASSGSS--QPELV------------------------TIPLVKGPKGFGFAIADSPT 600

  Fly   726 -------IDPEFYNSLIWVKDNNIDECGLELWFSVDFEVLGQIIHHELKENGEKERVTEENKEEY 783
                   :|.::...|  .|.:.|.|                 |:|:..:|....:|.|..|:..
  Rat   601 GQKVKMILDSQWCQGL--QKGDIIKE-----------------IYHQNVQNLTHLQVVEVLKQFP 646

  Fly   784 ITLMTEWRMTRG-------------IEQQTKTFLEGFNEVVPLEWLKYFDERELELILCGMQDVD 835
            :.......:.||             ..::|...||..||..| :.:.:    ...:|..|...:|
  Rat   647 VGADVPLLILRGGPCSPTKTAKMKTDTKETSGSLETINEPTP-QPMPF----PPSIIRSGSPKLD 706

  Fly   836 VED--WQRNTIYRHYNRNSKQVVWFWQFVRETDN---------------------------EKRA 871
            ..:  .:..|:|.....|:|.:.   .|:|:.::                           ||..
  Rat   707 PSEVYLKSKTLYEDKPPNTKDLD---VFLRKQESGFGFRVLGGDGPDQSIYIGAIIPLGAAEKDG 768

  Fly   872 RL-----LQFVTGTCRVPVGG-----FAELM---GSNG---------------------PQRFCI 902
            ||     |..:.|   :||.|     ..:||   ..||                     ||.|  
  Rat   769 RLRAADELMCIDG---IPVKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDESPQAF-- 828

  Fly   903 EKVGKETWLPRSHTCFNRLDLP----PYKSYDQLVEKLTFAIEETEGF 946
                .::..||    .||.:||    |.:|||.::::     :|.|||
  Rat   829 ----SQSGSPR----LNRTELPTRSAPQESYDVILQR-----KENEGF 863

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Su(dx)NP_001259898.1 C2_E3_ubiquitin_ligase 48..173 CDD:175988
WW 364..396 CDD:197736 14/45 (31%)
WW 397..426 CDD:278809 13/28 (46%)
WW 478..509 CDD:197736 8/39 (21%)
WW 522..554 CDD:197736 6/31 (19%)
HECTc 594..946 CDD:238033 82/451 (18%)
HECTc 620..946 CDD:214523 79/425 (19%)
Magi3NP_620784.3 Interaction with ADRB1 and TGFA. /evidence=ECO:0000269|PubMed:16316992 18..108
PDZ_signaling 24..103 CDD:238492
NK 125..>199 CDD:418433 2/5 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 184..266 14/86 (16%)
HUL4 <211..>373 CDD:227354 40/175 (23%)
WW 299..329 CDD:238122 12/29 (41%)
WW 345..375 CDD:238122 13/29 (45%)
Interaction with PTEN. /evidence=ECO:0000250 413..495 22/117 (19%)
PDZ 416..496 CDD:214570 23/115 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 550..575 9/29 (31%)
PDZ 578..659 CDD:214570 18/123 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 665..700 7/39 (18%)
PDZ 729..812 CDD:214570 15/88 (17%)
Interaction with ADGRB1. /evidence=ECO:0000250 729..811 15/87 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 818..847 9/38 (24%)
PDZ_signaling 851..936 CDD:238492 6/18 (33%)
Interaction with LPAR2 and GRIN2B. /evidence=ECO:0000250 852..939 5/17 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 939..976
PDZ_signaling 1023..1101 CDD:238492
PTZ00112 1115..>1405 CDD:240274
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1124..1146
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1167..1470
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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