DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Su(dx) and NEDD4L

DIOPT Version :9

Sequence 1:	NP_001259898.1	Gene:	Su(dx) / 33379	FlyBaseID:	FBgn0003557	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	XP_006722489.1	Gene:	NEDD4L / 23327	HGNCID:	7728	Length:	1019	Species:	Homo sapiens

Alignment Length:	1016	Identity:	345/1016 - (33%)
Similarity:	490/1016 - (48%)	Gaps:	206/1016 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 NPYVELLIDSKSKRK------TDLVKNSYLPKWNEEFTVLITP-NSTLHFKVLDHSSFRKDAMLG 126
            :|||:|.:....:.:      |..:|.:..|||||||...:.| |..|.|:|.|.:...:|..||
Human    68 DPYVKLSLYVADENRELALVQTKTIKKTLNPKWNEEFYFRVNPSNHRLLFEVFDENRLTRDDFLG 132

  Fly   127 ERIINLAHI--------------------LQHYNGRCEFLELTIDLFVTS------KSDNR--QT 163
            :..:.|:|:                    ..|.:....||.|.:.....:      .||.|  ..
Human   133 QVDVPLSHLPTEDPTMERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDME 197

  Fly   164 KSGELVAILNGLKLDMSKLQIQPV----------AGQ----QNGNPPVQAVNPSVVSDAAAGRSC 214
            ...|:|...:.......:|...|:          .|:    .:.|...|...||::..::...:
Human   198 HGWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDN- 261

  Fly   215 MIYGGVR------ARMRLRSSSGNSNGGETRSPLPNGGGDHRRSTQAPPVWEQQQQQSQNQQQPL 273
                .:|      |..|.||....|   |...|.|:.|||      .|..||...::
Human   262 ----NIRQINQEAAHRRFRSRRHIS---EDLEPEPSEGGD------VPEPWETISEE-------- 305

  Fly   274 RMVNGSGAAVPQTAPYPQQPPAPA-------LARPLTQVYGALPENT----------QPAAVYLP 321
              ||.:|.::....|.|  |.:|.       |:..|::.....|::.          :|::....
Human   306 --VNIAGDSLGLALPPP--PASPGSRTSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRS 366

  Fly   322 AGGGAAVGPPGVAGPPIEQPGVGLPVSQSTDPQLQTQPADDEPLPAGWEIRLDQYGRRYYVDHNT 386
            .....||...|...||      ..|..::   :..|....:||.|
Human   367 CSVTDAVAEQGHLPPP------SAPAGRA---RSSTVTGGEEPTP-------------------- 402

  Fly   387 RSTYWEKPTP-LPPGWEIRKDGRGRVYYVDHNTRKTTWQRP---------------NSERLMHFQ 435
             |..:...|| ||.|||.|||.:||.|||:||.|.|||.||               ::..|:..|
Human   403 -SVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQ 466

  Fly   436 ----------------HWQGQRAHVVSQGNQRYLYSQQQQQPTAVTA-----QVTQDDEDALGPL 479
                            ..:|.:...|.:..:..|.:.|..||:...:     :|||..      |
Human   467 IRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSF------L 525

  Fly   480 PDGWEKKIQSDNRVYFVNHKNRTTQWEDPRTQ-----GQEVSL-INE-GPLPPGWEIRYTAAGER 537
            |.|||.:|..:.|.:|::|..:||.|||||.:     ..:.|| .|: ||||||||.|....|..
Human   526 PPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRT 590

  Fly   538 FFVDH---------NTRR---------TTFEDPRPGAPKGAKGVYGVPRAYERSFRWKLSQFRYL 584
            |::||         :||.         |.:||||...|    .:.|....|.|.|:.|...||..
Human   591 FYIDHSSQVLCGENDTRESVPSYDSKITQWEDPRLQNP----AITGPAVPYSREFKQKYDYFRKK 651

  Fly   585 CQSNA-LPSHIKITVTRQTLFEDSYHQIMRLPAYE-LRRRLYIIFRGEEGLDYGGVSREWFFLLS 647
            .:..| :|:..::.:.|..:||:||.:||.:...: |:.||:|.|..|:|||||||:||||||||
Human   652 LKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLS 716

  Fly   648 HEVLNPMYCLFEYANKNNYSLQINPAS-YVNPDHLQYFKFIGRFIAMALYHGRFIYSGFTMPFYK 711
            .|:.||.|.||||:..:||:|||||.| ..|.|||.||.||||...:|::||:.:...|..||||
Human   717 KEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYK 781

  Fly   712 RMLNKKLTIKDIETIDPEFYNSLIWVKDNNIDECGLELWFSVDFEVLGQIIHHELKENGEKERVT 776
            .||.|::|:.|:|::|.|:||||.|:.:|  |...|:|.|.:|.|..||....:||.||.:..||
Human   782 MMLGKQITLNDMESVDSEYYNSLKWILEN--DPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVT 844

  Fly   777 EENKEEYITLMTEWRMTRGIEQQTKTFLEGFNEVVPLEWLKYFDERELELILCGMQDVDVEDWQR 841
            .|||.|||.|:.:||....:::|...|||||.|::|::.:|.|||.||||::||:.||||.||::
Human   845 NENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQ 909

  Fly   842 NTIYRH-YNRNSKQVVWFWQFVRETDNEKRARLLQFVTGTCRVPVGGFAELMGSNGPQRFCIEKV 905
            ::||:: |..|...:.|||:.|...|.|||.|||||||||.|||:.|||||.||||||.|.||:.
Human   910 HSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQW 974

  Fly   906 GKETWLPRSHTCFNRLDLPPYKSYDQLVEKLTFAIEETEGF 946
            |....|||:||||||||||||::::.|.|||..|:|..:||
Human   975 GSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 1015

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(dx)	NP_001259898.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988	33/138 (24%)
		WW	364..396	CDD:197736	3/31 (10%)
		WW	397..426	CDD:278809	19/28 (68%)
		WW	478..509	CDD:197736	14/30 (47%)
		WW	522..554	CDD:197736	18/49 (37%)
		HECTc	594..946	CDD:238033	183/354 (52%)
		HECTc	620..946	CDD:214523	175/327 (54%)
NEDD4L	XP_006722489.1	C2_NEDD4_NEDD4L	21..179	CDD:175999	28/110 (25%)
		WW	224..250	CDD:278809	3/25 (12%)
		WW	413..442	CDD:278809	19/28 (68%)
		WW	526..556	CDD:238122	14/29 (48%)
		WW	575..625	CDD:197736	18/49 (37%)
		HECTc	662..1016	CDD:238033	185/356 (52%)
		HECTc	686..1015	CDD:214523	176/330 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100256
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2273
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.740