Protein Alignment Su(dx) and NEDD4L

DIOPT Version :10

• Sequence 1: NP_476753.1
• Gene: Su(dx) / 33379
• FlyBaseID: FBgn0003557
• Length: 949
• Species: Drosophila melanogaster
• Sequence 2: XP_005266715.3
• Gene: NEDD4L / 23327
• HGNCID: 7728
• Length: 1272
• Species: Homo sapiens
• Alignment Length: 1114
• Identity: 346/1114 - (31%)
• Similarity: 476/1114 - (42%)
• Gaps: 375/1114 - (33%)

  Fly   174 GLKL-------DMSKLQIQPVAGQQNGNPPVQAVNP-----SVVSDA--AAGRSCMI-------- 216
            ||::       |:.::::.|:.....|.|  .|..|     ..|.||  ::|:.|.:
Human   189 GLRIQHRASSADVRQVRLLPLGPDGQGGP--AAAEPRRWSLQHVPDASGSSGKRCFVFQLQQPQQ 251

  Fly   217 ------------YGGVRA-------RMRL----------RSSSGNSNGGETRSPL---PNGG--- 246
                        :.|.:.       |:||          ||..|:..  |.|..|   |..|
Human   252 GASGPGSDLNFGFTGTKGDRLVRYPRIRLERSTSYPTQPRSERGSPT--EDRGALEASPRAGRMA 314

  Fly   247 GDHRRSTQAPPVWEQQQ-----QQSQNQ-QQPLRMVNGSGAAVPQTAPY-PQQPPA--------- 295
            .:.||:..|....:.|.     :|.||. ||..|::...|   |:.||. |::..|
Human   315 PEIRRTNSAERTPQGQGCTFKIRQDQNAGQQHFRILVTRG---PEEAPQNPEEKSAKSPVSTGAD 376

  Fly   296 ----------------------PALARPLT-------------QVYGALPENTQPAAVYLPAGGG 325
                                  |.:.||.|             :|.|.|    :....|:|..||
Human   377 TTTRDDFLGQVDVPLSHLPTEDPTMERPYTFKDFLLRPRSHKSRVKGFL----RLKMAYMPKNGG 437

  Fly   326 AAVGPPGVAGPPIEQPG-------VGLPVSQSTDPQLQTQ-PADDEPLPAGWEIRLDQYGRRYYV 382
            ..           |:..       .|..|..|.|...|.| .....|||.|||.::|..||.|||
Human   438 QD-----------EENSDQRDDMEHGWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYV 491

  Fly   383 DHNTRSTYW-------------------------------------------------------- 391
            :||.|:|.|
Human   492 NHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETIS 556

  Fly   392 ----------------------------------------------------------------- 391
                                                                             
Human   557 EEVNIAGDSLGLALPPPPASPGSRTSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCS 621

  Fly   392 -----------------------------EKPTP----------LPPGWEIRKDGRGRVYYVDHN 417
                                         |:|||          ||.|||.|||.:||.|||:||
Human   622 VTDAVAEQGHLPPPSAPAGRARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHN 686

  Fly   418 TRKTTWQRP---------------NSERLMHFQ----------------HWQGQRAHVVSQGNQR 451
            .|.|||.||               ::..|:..|                ..:|.:...|.:..:.
Human   687 NRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKD 751

  Fly   452 YLYSQQQQQPTAVTA-----QVTQDDEDALGPLPDGWEKKIQSDNRVYFVNHKNRTTQWEDPRTQ 511
            .|.:.|..||:...:     :|||..      ||.|||.:|..:.|.:|::|..:||.|||||.:
Human   752 TLSNPQSPQPSPYNSPKPQHKVTQSF------LPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLK 810

  Fly   512 -----GQEVSL-INE-GPLPPGWEIRYTAAGERFFVDH---------NTRR---------TTFED 551
                 ..:.|| .|: ||||||||.|....|..|::||         :||.         |.:||
Human   811 FPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHSSQVLCGENDTRESVPSYDSKITQWED 875

  Fly   552 PRPGAPKGAKGVYGVPRAYERSFRWKLSQFRYLCQSNA-LPSHIKITVTRQTLFEDSYHQIMRLP 615
            ||...|    .:.|....|.|.|:.|...||...:..| :|:..::.:.|..:||:||.:||.:.
Human   876 PRLQNP----AITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVK 936

  Fly   616 AYE-LRRRLYIIFRGEEGLDYGGVSREWFFLLSHEVLNPMYCLFEYANKNNYSLQINPAS-YVNP 678
            ..: |:.||:|.|..|:|||||||:||||||||.|:.||.|.||||:..:||:|||||.| ..|.
Human   937 RPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNE 1001

  Fly   679 DHLQYFKFIGRFIAMALYHGRFIYSGFTMPFYKRMLNKKLTIKDIETIDPEFYNSLIWVKDNNID 743
            |||.||.||||...:|::||:.:...|..||||.||.|::|:.|:|::|.|:||||.|:.:|  |
Human  1002 DHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILEN--D 1064

  Fly   744 ECGLELWFSVDFEVLGQIIHHELKENGEKERVTEENKEEYITLMTEWRMTRGIEQQTKTFLEGFN 808
            ...|:|.|.:|.|..||....:||.||.:..||.|||.|||.|:.:||....:::|...|||||.
Human  1065 PTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFT 1129

  Fly   809 EVVPLEWLKYFDERELELILCGMQDVDVEDWQRNTIYRH-YNRNSKQVVWFWQFVRETDNEKRAR 872
            |::|::.:|.|||.||||::||:.||||.||::::||:: |..|...:.|||:.|...|.|||.|
Human  1130 ELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIR 1194

  Fly   873 LLQFVTGTCRVPVGGFAELMGSNGPQRFCIEKVGKETWLPRSHTCFNRLDLPPYKSYDQLVEKLT 937
            ||||||||.|||:.|||||.||||||.|.||:.|....|||:||||||||||||::::.|.|||.
Human  1195 LLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLL 1259

  Fly   938 FAIEETEGF 946
            .|:|..:||
Human  1260 MAVENAQGF 1268

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Su(dx)	NP_476753.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988
		WW	364..396	CDD:197736	19/181 (10%)
		HUL4	<395..946	CDD:227354	266/625 (43%)
NEDD4L	XP_005266715.3	PHA03247	<79..404	CDD:223021	42/221 (19%)
		C2	<379..432	CDD:472691	7/56 (13%)
		WW	477..503	CDD:459800	14/25 (56%)
		WW	666..695	CDD:459800	19/28 (68%)
		WW	779..809	CDD:238122	14/29 (48%)
		WW	828..878	CDD:197736	18/49 (37%)
		HECTc	939..1268	CDD:214523	176/330 (53%)