DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Su(dx) and WWC1

DIOPT Version :9

Sequence 1:	NP_001259898.1	Gene:	Su(dx) / 33379	FlyBaseID:	FBgn0003557	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	XP_011532787.1	Gene:	WWC1 / 23286	HGNCID:	29435	Length:	1185	Species:	Homo sapiens

Alignment Length:	161	Identity:	46/161 - (28%)
Similarity:	73/161 - (45%)	Gaps:	33/161 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   478 PLPDGWEKKIQSDNRVYFVNHKNRTTQWEDPRTQGQE----VSLINEGPLPPGWEIRYTAAGERF 538
            |||:|||:....|.:||:::|.||||.|.|||.:..:    ...|:: .||.|||..|......:
Human     7 PLPEGWEEARDFDGKVYYIDHTNRTTSWIDPRDRYTKPLTFADCISD-ELPLGWEEAYDPQVGDY 70

  Fly   539 FVDHNTRRTTFEDPRPGAPKGAKGVYGVPRAYERSFRWKLSQFRYL-----CQSNALPSHIKITV 598
            |:||||:.|..||||                    .:|:..|...|     ....||.:..:|..
Human    71 FIDHNTKTTQIEDPR--------------------VQWRREQEHMLKDYLVVAQEALSAQKEIYQ 115

  Fly   599 TRQ---TLFEDSYHQIMRLPAYELRRRLYII 626
            .:|   .|.:..|.|:..:..::|..::.::
Human   116 VKQQRLELAQQEYQQLHAVWEHKLGSQVSLV 146

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(dx)	NP_001259898.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988
		WW	364..396	CDD:197736
		WW	397..426	CDD:278809
		WW	478..509	CDD:197736	16/30 (53%)
		WW	522..554	CDD:197736	15/31 (48%)
		HECTc	594..946	CDD:238033	6/36 (17%)
		HECTc	620..946	CDD:214523	0/7 (0%)
WWC1	XP_011532787.1	WW	9..39	CDD:238122	15/29 (52%)
		WW	55..84	CDD:278809	13/28 (46%)
		ALDH-SF	429..>481	CDD:299846
		C2_Kibra	721..844	CDD:176062
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900