DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Su(dx) and HECW1

DIOPT Version :9

Sequence 1:	NP_001259898.1	Gene:	Su(dx) / 33379	FlyBaseID:	FBgn0003557	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	XP_016867371.1	Gene:	HECW1 / 23072	HGNCID:	22195	Length:	1639	Species:	Homo sapiens

Alignment Length:	1022	Identity:	306/1022 - (29%)
Similarity:	420/1022 - (41%)	Gaps:	294/1022 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   166 GELVAILNGLKLDMSKLQIQPVAGQQNGNPPVQ------------AVNPSVVSDAAAGRSCMIYG 218
            |...::.||...|.   ...|..|.::.:.|.|            ..:||..|.:....||.
Human   668 GHFPSLANGAAQDG---DTHPSTGSESDSSPRQGGDHSCEGCDASCCSPSCYSSSCYSTSCY--- 726

  Fly   219 GVRARMRLRSSSGNSNGGETRSPLPNGG---GDHRR--STQAPPVWEQQQQQSQNQQQPLRMVNG 278
                       |.:.......||....|   ..|.|  |..:..:.|.....||:.::.   .|.
Human   727 -----------SSSCYSASCYSPSCYNGNRFASHTRFSSVDSAKISESTVFSSQDDEEE---ENS 777

  Fly   279 SGAAVPQTAPYPQQPPAPALARPLTQVYGALPENTQPAAVYLPAGGGAAVGPPG----VAGPPIE 339
            :..:||.:...|:..|        ....||.|...:.||    ..|.....|.|    ||||...
Human   778 AFESVPDSMQSPELDP--------ESTNGAGPWQDELAA----PSGHVERSPEGLESPVAGPSNR 830

  Fly   340 QPGV------GLPVSQ--STDPQLQTQPADDEPLPAGWEIRLDQYGRRYYVDHNTRSTYWEKPT- 395
            :.|.      ..||||  |..|:....|..|||||..||.|:|.:||.:||||..|:|.|::||
Human   831 REGECPILHNSQPVSQLPSLRPEHHHYPTIDEPLPPNWEARIDSHGRVFYVDHVNRTTTWQRPTA 895

  Fly   396 ----------------------------------------------------------------- 395

Human   896 AATPDGMRRSGSIQQMEQLNRRYQNIQRTIATERSEEDSGSQSCEQAPAGGGGGGGSDSEAESSQ 960

  Fly   396 ----------------------------------------------------------------- 395

Human   961 SSLDLRREGSLSPVNSQKITLLLQSPAVKFITNPEFFTVLHANYSAYRVFTSSTCLKHMILKVRR 1025

  Fly   396 --------------------------PLPPGWEIRKDGRGRVYYVDHNTRKTTWQRPN------- 427
                                      .||.||||:.|.:|:.::||||:|.||:..|.
Human  1026 DARNFERYQHNRDLVNFINMFADTRLELPRGWEIKTDQQGKSFFVDHNSRATTFIDPRIPLQNGR 1090

  Fly   428 -SERLMHFQHWQGQRAHVVSQGNQ--RYLYSQQQQQP--TAVTAQVTQDDEDALGPLPDGWEKKI 487
             ...|.|.||.|..|::...:.::  |...:....:|  :.|.|..:|...::| ||       .
Human  1091 LPNHLTHRQHLQRLRSYSAGEASEVSRNRGASLLARPGHSLVAAIRSQHQHESL-PL-------A 1147

  Fly   488 QSDNRVYFVNHKN--RTTQWEDP---------------RTQGQE--------------VSLINEG 521
            .:|..|.|:...|  ...|...|               ||:|..              :||..|.
Human  1148 YNDKIVAFLRQPNIFEMLQERQPSLARNHTLREKIHYIRTEGNHGLEKLSCDADLVILLSLFEEE 1212

  Fly   522 -----PLPPGWEIRYTAAGERFFVDHNTRRTTFEDPR--PGAPKGAKGVYGVPRAYERSFRWKLS 579
                 ||...:...|:         .:.|.:....|:  ||..:.:.   ..|..|.|.|..||.
Human  1213 IMSYVPLQAAFHPGYS---------FSPRCSPCSSPQNSPGLQRASA---RAPSPYRRDFEAKLR 1265

  Fly   580 QFRYLCQSNAL---PSHIKITVTRQTLFEDSYHQIMRLPAYELRR-RLYIIFRGEEGLDYGGVSR 640
            .|....::...   |..||:.:.|..|.|.:::|:|.....||:| :||:.|.|||||||.|.||
Human  1266 NFYRKLEAKGFGQGPGKIKLIIRRDHLLEGTFNQVMAYSRKELQRNKLYVTFVGEEGLDYSGPSR 1330

  Fly   641 EWFFLLSHEVLNPMYCLFEYANKNNYSLQINPASYVNPDHLQYFKFIGRFIAMALYHGRFIYSGF 705
            |:|||||.|:.||.|.||||:..:.|::||:|.|....:||::|:|.||.:.:||.|...:.:.|
Human  1331 EFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFVENHLEWFRFSGRILGLALIHQYLLDAFF 1395

  Fly   706 TMPFYKRMLNKKLTIKDIETIDPEFYNSLIWVKDNNIDECGLELWFSVDFEVLGQIIHHELKENG 770
            |.||||.:|.....:.|:|.:|.||:.||.|:|||||.:. |:|.|:|:.||.||:...|||..|
Human  1396 TRPFYKALLRLPCDLSDLEYLDEEFHQSLQWMKDNNITDI-LDLTFTVNEEVFGQVTERELKSGG 1459

  Fly   771 EKERVTEENKEEYITLMTEWRMTRGIEQQTKTFLEGFNEVVPLEWLKYFDERELELILCGMQDVD 835
            ...:|||:||:|||..|.:||:.||:.|||:..:.||.|||....:..||.|||||::.|..::|
Human  1460 ANTQVTEKNKKEYIERMVKWRVERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEID 1524

  Fly   836 VEDWQRNTIYR-HYNRNSKQVVWFWQFVRETDNEKRARLLQFVTGTCRVPVGGFAELMGSNGPQR 899
            :.||:.||.|| .|:.....:.|||..|...:||:|.|||||||||..||..|||.|.||||.:|
Human  1525 LNDWRNNTEYRGGYHDGHLVIRWFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFAALRGSNGLRR 1589

  Fly   900 FCIEKVGKETWLPRSHTCFNRLDLPPYKSYDQLVEKLTFAIEETEGF 946
            |||||.||.|.|||:||||||||||||.||..|.|||..|:|||..|
Human  1590 FCIEKWGKITSLPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTF 1636

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(dx)	NP_001259898.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988	1/6 (17%)
		WW	364..396	CDD:197736	18/188 (10%)
		WW	397..426	CDD:278809	15/28 (54%)
		WW	478..509	CDD:197736	8/47 (17%)
		WW	522..554	CDD:197736	5/33 (15%)
		HECTc	594..946	CDD:238033	180/353 (51%)
		HECTc	620..946	CDD:214523	171/327 (52%)
HECW1	XP_016867371.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810