DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Su(dx) and Ube3a

DIOPT Version :9

Sequence 1:	NP_001259898.1	Gene:	Su(dx) / 33379	FlyBaseID:	FBgn0003557	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	NP_001380595.1	Gene:	Ube3a / 22215	MGIID:	105098	Length:	870	Species:	Mus musculus

Alignment Length:	518	Identity:	158/518 - (30%)
Similarity:	251/518 - (48%)	Gaps:	81/518 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   470 QDDEDALGPLPDGWEKKIQ---SDNRVYFVNHKNRTTQWEDPRTQGQEVSL-------------- 517
            :|||:   |:|:..|..:|   .|.|      :|:    :.||....|..|
Mouse   390 EDDEE---PIPESSELTLQELLGDER------RNK----KGPRVDPLETELGVKTLDCRKPLISF 441

  Fly   518 ---INEGPLPPGWEI--RYTAAGERFFVDHNTRRTTFEDPRP---GAPKGAKGVYGVPRAYERSF 574
               ||| ||....|:  .||     ||......:.:|. ..|   .|.....|:|     |:...
Mouse   442 EEFINE-PLNDVLEMDKDYT-----FFKVETENKFSFM-TCPFILNAVTKNLGLY-----YDNRI 494

  Fly   575 RW----KLSQFRYLCQSNALPSHIKITVTRQTLFEDSYHQI----MRLPAYELRRRLYIIFRGEE 631
            |.    :::....|.|...|..::::.|.|..:.:|:..::    |..|| :|:::||:.|.||:
Mouse   495 RMYSERRITVLYSLVQGQQLNPYLRLKVRRDHIIDDALVRLEMIAMENPA-DLKKQLYVEFEGEQ 558

  Fly   632 GLDYGGVSREWFFLLSHEVLNPMYCLFEYANKNNYSLQINPASYVNPDHLQYFKFIGRFIAMALY 696
            |:|.||||:|:|.|:..|:.||...:|.| ::.......||:|:.....   |..||..:.:|:|
Mouse   559 GVDEGGVSKEFFQLVVEEIFNPDIGMFTY-DEATKLFWFNPSSFETEGQ---FTLIGIVLGLAIY 619

  Fly   697 HGRFIYSGFTMPFYKRMLNKKLTIKDIETIDPEFYNSLIWVKDNNIDECGLELWFSVDFEV---- 757
            :...:...|.|..|::::.||.|.:|:....|..|.||   ||....|..:|....:.|::
Mouse   620 NNCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSL---KDLLEYEGSVEDDMMITFQISQTD 681

  Fly   758 -LGQIIHHELKENGEKERVTEENKEEYITLMTEWRMTRGIEQQTKTFLEGFNEVVPLEWLKY-FD 820
             .|..:.::|||||:|..:|.||::|::.|.:::.:.:.:|:|.|.|..||:.|.....||| |.
Mouse   682 LFGNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFR 746

  Fly   821 ERELELILCGMQDVDVEDWQRNTIY-RHYNRNSKQVVWFWQFVRETDNEKRARLLQFVTGTCRVP 884
            ..|:||::||.:::|.:..:..|.| ..|.|.|..:..||:.|....:|::...|||.|||.|.|
Mouse   747 PEEIELLICGSRNLDFQALEETTEYDGGYTRESVVIREFWEIVHSFTDEQKRLFLQFTTGTDRAP 811

  Fly   885 VGGFAELMGSNGPQRFCIEKVGKET-WLPRSHTCFNRLDLPPYKSYDQLVEKLTFAIEETEGF 946
            |||..:|       :..|.|.|.:| .||.||||||.|.||.|.|.::|.|:|..||...:||
Mouse   812 VGGLGKL-------KMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAKGF 867

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(dx)	NP_001259898.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988
		WW	364..396	CDD:197736
		WW	397..426	CDD:278809
		WW	478..509	CDD:197736	7/33 (21%)
		WW	522..554	CDD:197736	8/33 (24%)
		HECTc	594..946	CDD:238033	122/363 (34%)
		HECTc	620..946	CDD:214523	115/333 (35%)
Ube3a	NP_001380595.1	AZUL	27..81	CDD:406862
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	171..223
		HECTc	518..868	CDD:238033	124/365 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810