Protein Alignment Su(dx) and Ube3a

DIOPT Version :10

• Sequence 1: NP_476753.1
• Gene: Su(dx) / 33379
• FlyBaseID: FBgn0003557
• Length: 949
• Species: Drosophila melanogaster
• Sequence 2: NP_035798.2
• Gene: Ube3a / 22215
• MGIID: 105098
• Length: 870
• Species: Mus musculus
• Alignment Length: 518
• Identity: 158/518 - (30%)
• Similarity: 251/518 - (48%)
• Gaps: 81/518 - (15%)

  Fly   470 QDDEDALGPLPDGWEKKIQ---SDNRVYFVNHKNRTTQWEDPRTQGQEVSL-------------- 517
            :|||:   |:|:..|..:|   .|.|      :|:    :.||....|..|
Mouse   390 EDDEE---PIPESSELTLQELLGDER------RNK----KGPRVDPLETELGVKTLDCRKPLISF 441

  Fly   518 ---INEGPLPPGWEI--RYTAAGERFFVDHNTRRTTFEDPRP---GAPKGAKGVYGVPRAYERSF 574
               ||| ||....|:  .||     ||......:.:|. ..|   .|.....|:|     |:...
Mouse   442 EEFINE-PLNDVLEMDKDYT-----FFKVETENKFSFM-TCPFILNAVTKNLGLY-----YDNRI 494

  Fly   575 RW----KLSQFRYLCQSNALPSHIKITVTRQTLFEDSYHQI----MRLPAYELRRRLYIIFRGEE 631
            |.    :::....|.|...|..::::.|.|..:.:|:..::    |..|| :|:::||:.|.||:
Mouse   495 RMYSERRITVLYSLVQGQQLNPYLRLKVRRDHIIDDALVRLEMIAMENPA-DLKKQLYVEFEGEQ 558

  Fly   632 GLDYGGVSREWFFLLSHEVLNPMYCLFEYANKNNYSLQINPASYVNPDHLQYFKFIGRFIAMALY 696
            |:|.||||:|:|.|:..|:.||...:|.| ::.......||:|:.....   |..||..:.:|:|
Mouse   559 GVDEGGVSKEFFQLVVEEIFNPDIGMFTY-DEATKLFWFNPSSFETEGQ---FTLIGIVLGLAIY 619

  Fly   697 HGRFIYSGFTMPFYKRMLNKKLTIKDIETIDPEFYNSLIWVKDNNIDECGLELWFSVDFEV---- 757
            :...:...|.|..|::::.||.|.:|:....|..|.||   ||....|..:|....:.|::
Mouse   620 NNCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSL---KDLLEYEGSVEDDMMITFQISQTD 681

  Fly   758 -LGQIIHHELKENGEKERVTEENKEEYITLMTEWRMTRGIEQQTKTFLEGFNEVVPLEWLKY-FD 820
             .|..:.::|||||:|..:|.||::|::.|.:::.:.:.:|:|.|.|..||:.|.....||| |.
Mouse   682 LFGNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFR 746

  Fly   821 ERELELILCGMQDVDVEDWQRNTIY-RHYNRNSKQVVWFWQFVRETDNEKRARLLQFVTGTCRVP 884
            ..|:||::||.:::|.:..:..|.| ..|.|.|..:..||:.|....:|::...|||.|||.|.|
Mouse   747 PEEIELLICGSRNLDFQALEETTEYDGGYTRESVVIREFWEIVHSFTDEQKRLFLQFTTGTDRAP 811

  Fly   885 VGGFAELMGSNGPQRFCIEKVGKET-WLPRSHTCFNRLDLPPYKSYDQLVEKLTFAIEETEGF 946
            |||..:|       :..|.|.|.:| .||.||||||.|.||.|.|.::|.|:|..||...:||
Mouse   812 VGGLGKL-------KMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAKGF 867

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Su(dx)	NP_476753.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988
		WW	364..396	CDD:197736
		HUL4	<395..946	CDD:227354	156/516 (30%)
Ube3a	NP_035798.2	AZUL	27..81	CDD:465173
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	171..223
		HECTc	518..868	CDD:238033	124/365 (34%)