DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Su(dx) and yap-1

DIOPT Version :9

Sequence 1:	NP_001259898.1	Gene:	Su(dx) / 33379	FlyBaseID:	FBgn0003557	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	NP_001369894.1	Gene:	yap-1 / 181267	WormBaseID:	WBGene00008748	Length:	442	Species:	Caenorhabditis elegans

Alignment Length:	360	Identity:	74/360 - (20%)
Similarity:	124/360 - (34%)	Gaps:	116/360 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   234 NGGETRSPLPN-----------------GGGDHRRSTQAPPVWEQQQQQSQNQQQPL--RMV--- 276
            |..:.::|||:                 |..|....|...|..:....|:     |:  |.|
Worm    47 NQNQKKNPLPSSYYHQKRNPGSSAHSPYGSVDESSRTAVSPAMDMVSNQA-----PIHTRQVSAP 106

  Fly   277 -------NGSGAAVPQTAPYP------QQPPAPALARPLTQVYGALPENTQPA---AVYLPAGGG 325
                   ||..:|   |.|:|      .|......|.|:|..|..:|.:.:..   |.|..||..
Worm   107 NLHTSVNNGQSSA---TVPHPSHHNVHHQHSKSVSALPMTIGYSPVPSHVKSVSHEANYSYAGLS 168

  Fly   326 AAVGPPGVAGPPIEQPGVGLPVSQSTDPQ----LQTQPADDEPLPAGWEIRLDQYGRRYYVDHNT 386
            ......|:.....|:       |.|.||.    :..|..:..|:|.|||:..|..|.||:.|||:
Worm   169 EIPQQQGMMQQNREK-------SLSLDPMRRPFMTPQDVEQLPMPQGWEMCYDSDGVRYFKDHNS 226

  Fly   387 RSTYWEKP-------TPLPPGWEIRKDGRGRVYYVDHNTRKTTW--------------QRPNSER 430
            ::|.|:.|       |....|..|.::.....|...|::|....              |..:.::
Worm   227 KTTTWDDPRLKQQEQTGFGLGENIGQNRYNNCYDNGHSSRSLPSIHQHQQMIPNHPQPQYSSQQQ 291

  Fly   431 LMHFQHWQGQR-------AHVVSQG-----------------------NQRYLYSQQQQQPTAVT 465
            :.:.|..|.:|       |.:::.|                       :..::|.||||
Worm   292 MDYIQQLQNERMMIQEKNAQLINSGLVDSPQPPYQAISPMSSTMMHSHDPNFMYQQQQQ------ 350

  Fly   466 AQVTQDDE--DALGPLPDGWEKKIQSDNRVYFVNH 498
            ||.:|..:  ..|..:|:.::....:|:....|::
Worm   351 AQNSQQQQTPHTLHQIPNQYQNSQMNDDSAMEVDY 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(dx)	NP_001259898.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988
		WW	364..396	CDD:197736	15/38 (39%)
		WW	397..426	CDD:278809	6/42 (14%)
		WW	478..509	CDD:197736	3/21 (14%)
		WW	522..554	CDD:197736
		HECTc	594..946	CDD:238033
		HECTc	620..946	CDD:214523
yap-1	NP_001369894.1	WW	206..236	CDD:238122	14/29 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900