DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Su(dx) and hecw-1

DIOPT Version :9

Sequence 1:	NP_001259898.1	Gene:	Su(dx) / 33379	FlyBaseID:	FBgn0003557	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	NP_001317872.1	Gene:	hecw-1 / 175438	WormBaseID:	WBGene00009738	Length:	1247	Species:	Caenorhabditis elegans

Alignment Length:	694	Identity:	207/694 - (29%)
Similarity:	308/694 - (44%)	Gaps:	138/694 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   350 STDPQLQTQPADD---------EPLPAGWEIRLDQYGRRYYVDHNTRSTYWEKPTPL-----PPG 400
            |.:|:...:.|.|         .|..:.|:..||...|::||:|.|:.|.|.||..|     .|.
Worm   580 SIEPKTSKKSAPDIMEIASSSQTPPESHWKTYLDAKKRKFYVNHVTKETRWTKPDTLNNNHIEPE 644

  Fly   401 WEIRK-----DGRGRVYYVDHNTRKTTWQR----PNSERLMHFQHWQGQRAHVVSQGNQRYLY-- 454
            ..:.|     ....|..::  ..|:|...|    |.|:.:..||..:.:.|...:| :...:|
Worm   645 TPVHKRLSDRSASPRNSFI--TPRRTITVRSAGCPKSDLIQFFQRDEFKTALYENQ-DAMQIYNE 706

  Fly   455 ------------------SQQQQQPTAVT-----AQVTQDDEDALGPLPDGWEKKIQSDNRVYFV 496
                              |:.:.||..|.     |.:||       |||.||| .|..:||..|:
Worm   707 CSVVRHAIHRIQKDLDPPSKFENQPLFVRFVNLFADITQ-------PLPSGWE-CITMNNRTVFL 763

  Fly   497 NHKNRTTQWEDPRTQGQEVSLINEGPLPPG------------------WEIRYTAAG-------- 535
            ||.|:.|.:.|||.:..|......|...|.                  .::|..|..
Worm   764 NHANKETSFYDPRIRRFETKTSRRGRSVPSRSSTAHKGKIDHALISKCEDLRKIAQDNFPQIAER 828

  Fly   536 --------ERF-------------------FVDHNTRRTTFEDPRPGAPKGAKGVYGVPRAYERS 573
                    |||                   .:|.||.:...|..            .:...||..
Worm   829 ISKKLMLIERFGGLAVASLANDLDITLALSMLDSNTEKLAGEGD------------NIKMFYEDM 881

  Fly   574 FRWKLSQFRYLCQSNALPSHIKITVTRQTLFEDSYHQIMRLPAYELRR-RLYIIFRGEEGLDYGG 637
            .:.||.:.         ||.:...|:|..|.:|::..|:.:..:.|:: ||:|.|.||..|||||
Worm   882 KKEKLGKG---------PSRLCWKVSRDRLLDDAFRIILNVDPFVLKKSRLHIRFEGELALDYGG 937

  Fly   638 VSREWFFLLSHEVLNPMYCLFEYANKNNYSLQINPASYVNPDHLQYFKFIGRFIAMALYHGRFIY 702
            :|||:|.|||.|:.:|....|||.. |:|.||:.|.........::....||.:|:|:.|..:|.
Worm   938 LSREFFILLSRELFHPKNGYFEYEG-NDYHLQLRPRGCETEKEKKWLILCGRVLALAVIHRCYID 1001

  Fly   703 SGFTMPFYKRMLNKKLTIKDIETIDPEFYNSLIWVKDNNIDECGLELWFSVDFEVLGQIIHHELK 767
            ..||..|||.:..:.:|:.|.:..|.|||.|:.|:.:|::.:  ||:.|.....|.|::...||.
Worm  1002 VFFTNVFYKSLQKRPVTLMDFKESDAEFYKSMNWLLENDVVD--LEMSFVYSSMVNGKLAEQELV 1064

  Fly   768 ENGEKERVTEENKEEYITLMTEWRMTRGIEQQTKTFLEGFNEVVPLEWLKYFDERELELILCGMQ 832
            ..||.:.|||.||.|:|.||.:.:..||:|:..:..|..||:::....|...:..:|:.||.|..
Worm  1065 PGGESQMVTEANKAEFIDLMCQKKAIRGVEKPLEILLTSFNQILNDNLLNSLESSDLKRILSGSL 1129

  Fly   833 DVDVEDWQRNTIYR-HYNRNSKQVVWFWQFVRETDNEKRARLLQFVTGTCRVPVGGFAELMGSNG 896
            ::|:.||:.||||: .|:.....|.|||:.:....|::|..||.||||:..||..||:.|.|:..
Worm  1130 ELDLNDWRTNTIYKGGYSDCHIVVEWFWEVIETMTNQERFDLLLFVTGSSSVPFEGFSALRGNEE 1194

  Fly   897 PQRFCIEKVGKETWLPRSHTCFNRLDLPPYKSYDQLVEKLTFAI 940
            ..:|||||.|..|..||:|||||||.||.|.:..||..||..||
Worm  1195 ISKFCIEKWGDATSFPRAHTCFNRLQLPSYNTKQQLKSKLQQAI 1238

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(dx)	NP_001259898.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988
		WW	364..396	CDD:197736	13/31 (42%)
		WW	397..426	CDD:278809	7/42 (17%)
		WW	478..509	CDD:197736	15/30 (50%)
		WW	522..554	CDD:197736	10/84 (12%)
		HECTc	594..946	CDD:238033	134/349 (38%)
		HECTc	620..946	CDD:214523	128/323 (40%)
hecw-1	NP_001317872.1	FBA_2	230..285	CDD:311601
		WW	603..634	CDD:197736	12/30 (40%)
		WW	746..777	CDD:197736	16/31 (52%)
		HECTc	918..1244	CDD:214523	129/324 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810