DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Su(dx) and herc-1

DIOPT Version :9

Sequence 1:	NP_001259898.1	Gene:	Su(dx) / 33379	FlyBaseID:	FBgn0003557	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	NP_490834.1	Gene:	herc-1 / 171700	WormBaseID:	WBGene00021685	Length:	1019	Species:	Caenorhabditis elegans

Alignment Length:	487	Identity:	133/487 - (27%)
Similarity:	229/487 - (47%)	Gaps:	94/487 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   513 QEVSLINEG----PLPPGWEIRYTAAGERFFVDH-NTR---------RTTFEDPRP--------- 554
            |::||||:.    ||            |.|::|. ||.         ..|.:||..
Worm   571 QKLSLINKTYHIIPL------------ETFYIDELNTSVDLKLEYVLELTRQDPNKTELDYWTHF 623

  Fly   555 -----GAPKGAKGVYGVPRAYERSF--RWKLSQFRYLCQSN-----------ALPSHIKITVTRQ 601
                 |..||           |..|  .|.:...|.  ||:           .|| |:::||.|:
Worm   624 PFLLNGVAKG-----------ELIFVEAWLMQTLRR--QSSLFNTAHGTIIFELP-HLELTVRRE 674

  Fly   602 TLFEDSYHQIMRLPAYELRRRLYIIFRGEEGLDYGGVSREWFFLLSHEVLNPMYCLFEYANKNNY 666
            .:..|:.:|:..|...:|::.|.:...||:..|.|||.:|:|.|:..::|...|.:|. .::.::
Worm   675 FIVSDTMNQMAGLSESDLQKPLKVNIAGEDADDAGGVRKEFFILVMRKILQSDYGMFS-EDEESH 738

  Fly   667 SLQIN--PASYVNPDHLQYFKFIGRFIAMALYHGRFIYSGFTMPFYKRMLNKKLTIKDIETIDPE 729
            .:..:  |:.:.:.:.   |..:||.:.:::|:...:...|.:..||.:|:....::|:..:.|.
Worm   739 LVWFSGLPSEFCDREQ---FHQLGRLVGLSIYNHSIVPFPFPLALYKYLLDTPPDLEDLCELSPS 800

  Fly   730 ----FYNSLIWVKDNNIDECGLELWFSVDFEVLGQIIHHELKENGEKERVTEENKEEYITLMTEW 790
                ....|.:.:|:..|..||.  |.:.|.:||:....||...|.::.||..|::||:.|....
Worm   801 EGKGLKMLLSYEEDDVEDVFGLN--FCISFNILGETHTTELLSGGTEKPVTNANRDEYVRLYVHH 863

  Fly   791 RMTRG----IEQQTKTFLEGFNEVVPLEWLKYFDERELELILCGMQDVDVEDWQRNTIYR-HYNR 850
            |:..|    |.||...|.:||:|.:....|::|...||:.::.|.::.|..:::...:|| .|:.
Worm   864 RLELGYNGEIAQQALLFRKGFSESLHSRTLRFFQPCELKEMIVGNENYDWNEFRDILMYRGEYSS 928

  Fly   851 NSKQVVWFWQ-FVRETDNEKRARLLQFVTGTCRVPVGGFAELMGSNGPQRFCIEKVGKETWLPRS 914
            :...:..||: |...||:|:| :.|||:||:.|:||.|:.||..:       |:....|: ||.:
Worm   929 SHPTIQAFWKAFFALTDDERR-KFLQFLTGSTRIPVSGWEELHAA-------IQPSAPES-LPVA 984

  Fly   915 HTCFNRLDLPPYKSYDQLVEKLTFAIEETEGF 946
            |||||.||||......:|:.:|..:||.||||
Worm   985 HTCFNLLDLPNIADDVELLRRLRISIEHTEGF 1016

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(dx)	NP_001259898.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988
		WW	364..396	CDD:197736
		WW	397..426	CDD:278809
		WW	478..509	CDD:197736
		WW	522..554	CDD:197736	10/41 (24%)
		HECTc	594..946	CDD:238033	104/363 (29%)
		HECTc	620..946	CDD:214523	97/337 (29%)
herc-1	NP_490834.1	ATS1	2..359	CDD:227511
herc-1	NP_490834.1	HECTc	667..1016	CDD:238033	104/363 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810