DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Su(dx) and wwp-1

DIOPT Version :9

Sequence 1:	NP_001259898.1	Gene:	Su(dx) / 33379	FlyBaseID:	FBgn0003557	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	NP_740775.1	Gene:	wwp-1 / 171647	WormBaseID:	WBGene00007009	Length:	794	Species:	Caenorhabditis elegans

Alignment Length:	936	Identity:	477/936 - (50%)
Similarity:	580/936 - (61%)	Gaps:	162/936 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 ASPTPTSSSGAGASGSANQGYHQLSVTIEEASLRNNGFLK-PNPYVELLIDSKS--KRKTDLVKN 89
            :|..|:||...|.....|.......||::   :.|..|.| .:.|||:..|:.|  .:||.:.|.
Worm     7 SSQQPSSSGSNGTPAQQNGSAKPSKVTVK---VVNASFTKAADCYVEITSDTSSAAPKKTTVKKK 68

  Fly    90 SYLPKWNEEFTVLITPNSTLHFKVLDHSSFRKDAMLGERIINLAHILQHYNGRCEFLELTIDLFV 154
            :..|:|||...|....:||:.|::|..:....|..||...:.|:.:.::.||  ||
Worm    69 TMAPEWNEHLNVHANESSTISFRLLQKAKLFDDTCLGMAKLKLSSLTRNENG--EF--------- 122

  Fly   155 TSKSDNRQTKSGELVAILNGLKL---DMSKLQIQPVAGQQN----GNPPVQAVNPSVVSDAAAGR 212
              |:|            :|.:.|   |.||:      |..|    |.|..:..:..|.::.||..
Worm   123 --KND------------INNISLLAKDSSKI------GTLNIIFSGYPERKRRSAGVRAETAASA 167

  Fly   213 SCMIYGGVRARMRLRSSSGNSNGGETRSPLPNGGGDHRRSTQAPPVWEQQQQQSQNQQQPLRMVN 277
            |              |.:..|||..|.|       ..||
Worm   168 S--------------SEASTSNGVATSS-------SARR-------------------------- 185

  Fly   278 GSGAAVPQTAPYPQQPPAPALARPLTQVYGALPENTQPAAVYLPAGGGAAVGPPGVAGPPIEQPG 342
                              ||.|:..|.   |.|.:|..||....|||..|.|.
Worm   186 ------------------PATAKRDTL---AAPTSTAAAAAAATAGGTPAAGA------------ 217

  Fly   343 VGLPVSQSTDPQLQTQPADDEPLPAGWEIRLDQYGRRYYVDHNTRSTYWEKPT--PLPPGWEIRK 405
                               :|.||.|||:|.|||||:|||||.|:||.||:|:  |||.|||:|:
Worm   218 -------------------EEQLPDGWEMRFDQYGRKYYVDHTTKSTTWERPSTQPLPQGWEMRR 263

  Fly   406 DGRGRVYYVDHNTRKTTWQRPNSERLMHFQHWQGQRAHVVSQGNQRYLYSQQQQQPTAVTAQVTQ 470
            |.||||||||||||.||||||.::.|...:.||..|...:.|..||:|.  ||...:|
Worm   264 DPRGRVYYVDHNTRTTTWQRPTADMLEAHEQWQSGRDQAMLQWEQRFLL--QQNNFSA------- 319

  Fly   471 DDEDALGPLPDGWEKKIQSDN--RVYFVNHKNRTTQWEDPRTQGQEVSLINEGPLPPGWEIRYTA 533
              :|.|||||:||||: |..|  |:|||||.|||||||||||||...|   :.|||.|||:|:|.
Worm   320 --DDPLGPLPEGWEKR-QDPNTSRMYFVNHVNRTTQWEDPRTQGFRGS---DQPLPDGWEMRFTE 378

  Fly   534 AGERFFVDHNTRRTTFEDPRPGAPKGAKGVYGVPRAYERSFRWKLSQFRYLCQSNALPSHIKITV 598
            .|..||:||.::.||:.|||.|.|.|..||.||..|.|:|||||::||||||.||::|:|:||||
Worm   379 QGVPFFIDHQSKTTTYNDPRTGKPVGPLGVVGVQMAMEKSFRWKIAQFRYLCLSNSVPNHVKITV 443

  Fly   599 TRQTLFEDSYHQIMRLPAYELRRRLYIIFRGEEGLDYGGVSREWFFLLSHEVLNPMYCLFEYANK 663
            :|..:||||:.:|||..|.:|||||||.||||||||||||:|||||||||||||||||||.||..
Worm   444 SRNNVFEDSFQEIMRKNAVDLRRRLYIQFRGEEGLDYGGVAREWFFLLSHEVLNPMYCLFMYAGN 508

  Fly   664 NNYSLQINPASYVNPDHLQYFKFIGRFIAMALYHGRFIYSGFTMPFYKRMLNKKLTIKDIETIDP 728
            |||||||||||:||||||:||::|||||||||:||:||||||||||||:|||||:.:||||.:|.
Worm   509 NNYSLQINPASFVNPDHLKYFEYIGRFIAMALFHGKFIYSGFTMPFYKKMLNKKIVLKDIEQVDS 573

  Fly   729 EFYNSLIWVKDNNIDECGLELWFSVDFEVLGQIIHHELKENGEKERVTEENKEEYITLMTEWRMT 793
            |.||||:|:||||||||.:||:|..|:|:||::..:||||.|.:..||||||.|||.|:.|||..
Worm   574 EIYNSLMWIKDNNIDECDMELYFVADYELLGELKTYELKEGGTEIAVTEENKLEYIELLVEWRFN 638

  Fly   794 RGIEQQTKTFLEGFNEVVPLEWLKYFDERELELILCGMQDVDVEDWQRNTIYRHYNRNSKQVVWF 858
            ||:|||||.|..|||.|.||||::|||||||||:|||||||||:||||||:||||...||||.||
Worm   639 RGVEQQTKAFFTGFNSVFPLEWMQYFDERELELLLCGMQDVDVDDWQRNTVYRHYAPQSKQVTWF 703

  Fly   859 WQFVRETDNEKRARLLQFVTGTCRVPVGGFAELMGSNGPQRFCIEKVGKETWLPRSHTCFNRLDL 923
            ||:||..|.|||||||||||||||||||||:|||||.|||.||||:||||.||||||||||||||
Worm   704 WQWVRSLDQEKRARLLQFVTGTCRVPVGGFSELMGSTGPQLFCIERVGKENWLPRSHTCFNRLDL 768

  Fly   924 PPYKSYDQLVEKLTFAIEETEGFCQE 949
            |||:|||||||||:.|||.||||..|
Worm   769 PPYRSYDQLVEKLSMAIEMTEGFGNE 794

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(dx)	NP_001259898.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988	32/127 (25%)
		WW	364..396	CDD:197736	22/33 (67%)
		WW	397..426	CDD:278809	23/28 (82%)
		WW	478..509	CDD:197736	23/32 (72%)
		WW	522..554	CDD:197736	17/31 (55%)
		HECTc	594..946	CDD:238033	267/351 (76%)
		HECTc	620..946	CDD:214523	253/325 (78%)
wwp-1	NP_740775.1	C2	29..147	CDD:301316	39/151 (26%)
		WW	221..250	CDD:278809	21/28 (75%)
		WW	255..284	CDD:278809	23/28 (82%)
		WW	325..357	CDD:197736	23/32 (72%)
		WW	367..398	CDD:197736	16/30 (53%)
		HECTc	440..792	CDD:238033	268/351 (76%)
		HECTc	463..791	CDD:214523	254/327 (78%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167166
Domainoid	1	1.000	509	1.000	Domainoid score	I163
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H21385
Inparanoid	1	1.050	858	1.000	Inparanoid score	I216
Isobase	1	0.950	-	0	Normalized mean entropy	S744
OMA	1	1.010	-	-		QHG52003
OrthoDB	1	1.010	-	-		D126241at33208
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	1	1.000	-	-		oto20615
orthoMCL	1	0.900	-	-		OOG6_100256
Panther	1	1.100	-	-	LDO	PTHR11254
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2273
SonicParanoid	1	1.000	-	-		X898
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	15	14.890