DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Su(dx) and Itch

DIOPT Version :9

Sequence 1:	NP_001259898.1	Gene:	Su(dx) / 33379	FlyBaseID:	FBgn0003557	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	NP_001230641.1	Gene:	Itch / 16396	MGIID:	1202301	Length:	864	Species:	Mus musculus

Alignment Length:	924	Identity:	476/924 - (51%)
Similarity:	606/924 - (65%)	Gaps:	102/924 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 QLSVTIEEASLRNN--GFLKPNPYVELLIDSKSKRKTDLVKNSYLPKWNEEFTVLITPNSTLHFK 112
            ||.:|:..|.|:.|  .:..|:||||:.:|.:|| ||:...|:..|||.:..||::||.|.|.|:
Mouse    19 QLQITVISAKLKENKKNWFGPSPYVEVTVDGQSK-KTEKCNNTNSPKWKQPLTVIVTPTSKLCFR 82

  Fly   113 VLDHSSFRKDAMLGERIINLAHILQHYNGRCEFLELTIDLFVTSKSDNRQTKS-GELVAILNGLK 176
            |..|.:.:.|.:||...:::...|:..|.:.|.:.:|:.|.    .|...|:: |:|...|:||:
Mouse    83 VWSHQTLKSDVLLGTAGLDIYETLKSNNMKLEEVVMTLQLV----GDKEPTETMGDLSVCLDGLQ 143

  Fly   177 LDMSKLQIQPVAGQQNGNPPVQAVNPSVVSDAAAGRSCMIYGGVRARMRLRSSSGNSNGGETRSP 241
                                   |...||::...  ||.           .|::.|.:|..||.
Mouse   144 -----------------------VEAEVVTNGET--SCS-----------ESTTQNDDGCRTRD- 171

  Fly   242 LPNGGGDHRRST---QAPPVWEQQQQQSQNQQQPLRMVNGSGAAVPQTAPYPQQPPAPALARPLT 303
                  |.|.||   :.|.|....:.:..|......:.|  |...|...|.|.:||.|...|| .
Mouse   172 ------DTRVSTNGSEDPEVAASGENKRANGNNSPSLSN--GGFKPSRPPRPSRPPPPTPRRP-A 227

  Fly   304 QVYGALPENTQPAAVYLPAGGGAAVG--PP-----------GVAGPPIEQPGVGLPVSQSTDPQ- 354
            .|.|:...|:.        ..|::.|  ||           |.....|    :.|.:|..:.|:
Mouse   228 SVNGSPSTNSD--------SDGSSTGSLPPTNTNVNTSTSEGATSGLI----IPLTISGGSGPRP 280

  Fly   355 LQTQPADDEPLPAGWEIRLDQYGRRYYVDHNTRSTYWEKPTPLPPGWEIRKDGRGRVYYVDHNTR 419
            |.|  ....|||.|||.|:||:||.|||||..:.|.|::|.|||||||.|.|..||:|||||.||
Mouse   281 LNT--VSQAPLPPGWEQRVDQHGRVYYVDHVEKRTTWDRPEPLPPGWERRVDNMGRIYYVDHFTR 343

  Fly   420 KTTWQRPNSERLMHFQHWQGQRAHV---VSQGNQRYLYSQQQQQPTAVTAQVTQDDE-DALGPLP 480
            .||||||..|.:.:::.||.||:.:   :.|.|||::|..|....|      :|:.| |.|||||
Mouse   344 TTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQRFIYGNQDLFAT------SQNKEFDPLGPLP 402

  Fly   481 DGWEKKIQSDNRVYFVNHKNRTTQWEDPRTQGQEVSLINEGPLPPGWEIRYTAAGERFFVDHNTR 545
            .||||:..|:.|||||||..|.|||||||:|||    :||.|||.|||:|:|..|..:|||||.|
Mouse   403 PGWEKRTDSNGRVYFVNHNTRITQWEDPRSQGQ----LNEKPLPEGWEMRFTVDGIPYFVDHNRR 463

  Fly   546 RTTFEDPRPGAPKGAKGVYGVPRAYERSFRWKLSQFRYLCQSNALPSHIKITVTRQTLFEDSYHQ 610
            .||:.|||.|  |.|.. .|...||.|.|:.|:..||:.||..|:|.||||||||:||||||:.|
Mouse   464 ATTYIDPRTG--KSALD-NGPQIAYVRDFKAKVQYFRFWCQQLAMPQHIKITVTRKTLFEDSFQQ 525

  Fly   611 IMRLPAYELRRRLYIIFRGEEGLDYGGVSREWFFLLSHEVLNPMYCLFEYANKNNYSLQINPASY 675
            ||.....:|||||::||.||||||||||:||||||||||||||||||||||.|:||.||||||||
Mouse   526 IMSFSPQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASY 590

  Fly   676 VNPDHLQYFKFIGRFIAMALYHGRFIYSGFTMPFYKRMLNKKLTIKDIETIDPEFYNSLIWVKDN 740
            :|||||:||:||||||||||:||:||.:||::|||||:|||.:.:||:|:|||||||||||||:|
Mouse   591 INPDHLKYFRFIGRFIAMALFHGKFIDTGFSLPFYKRILNKPVGLKDLESIDPEFYNSLIWVKEN 655

  Fly   741 NIDECGLELWFSVDFEVLGQIIHHELKENGEKERVTEENKEEYITLMTEWRMTRGIEQQTKTFLE 805
            ||:|||||::||||.|:||:|..|:||.||....||||||||||.::.|||::||:|:||:.|.|
Mouse   656 NIEECGLEMYFSVDKEILGEIKSHDLKPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFE 720

  Fly   806 GFNEVVPLEWLKYFDERELELILCGMQDVDVEDWQRNTIYRHYNRNSKQVVWFWQFVRETDNEKR 870
            ||||::|.::|:|||.:|||::|||||::|:.||||:.|||||.|.|||::||||||:|.|||||
Mouse   721 GFNEILPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHAIYRHYTRTSKQIMWFWQFVKEIDNEKR 785

  Fly   871 ARLLQFVTGTCRVPVGGFAELMGSNGPQRFCIEKVGKETWLPRSHTCFNRLDLPPYKSYDQLVEK 935
            .|||||||||||:||||||:||||||||:|||||||||.||||||||||||||||||||:||.||
Mouse   786 MRLLQFVTGTCRLPVGGFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEK 850

  Fly   936 LTFAIEETEGFCQE 949
            |.|||||||||.||
Mouse   851 LLFAIEETEGFGQE 864

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(dx)	NP_001259898.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988	41/125 (33%)
		WW	364..396	CDD:197736	19/31 (61%)
		WW	397..426	CDD:278809	21/28 (75%)
		WW	478..509	CDD:197736	21/30 (70%)
		WW	522..554	CDD:197736	19/31 (61%)
		HECTc	594..946	CDD:238033	263/351 (75%)
		HECTc	620..946	CDD:214523	246/325 (76%)
Itch	NP_001230641.1	C2_E3_ubiquitin_ligase	17..140	CDD:175988	41/125 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	151..294		42/179 (23%)
		WW	289..318	CDD:278809	17/28 (61%)
		WW	321..350	CDD:278809	21/28 (75%)
		Required for interaction with FYN. /evidence=ECO:0000250	356..432		38/81 (47%)
		WW	401..430	CDD:278809	19/28 (68%)
		WW	440..471	CDD:197736	18/30 (60%)
		HECTc	509..862	CDD:238033	264/352 (75%)
		HECTc	533..861	CDD:214523	247/327 (76%)
		MAP kinase docking site	535..544		6/8 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	529	1.000	Domainoid score	I292
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	973	1.000	Inparanoid score	I318
Isobase	1	0.950	-	0	Normalized mean entropy	S744
OMA	1	1.010	-	-		QHG52003
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	1	1.000	-	-		otm44001
orthoMCL	1	0.900	-	-		OOG6_100256
Panther	1	1.100	-	-	O	PTHR11254
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2273
SonicParanoid	1	1.000	-	-		X898
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.810