Protein Alignment Su(dx) and HECTD2

DIOPT Version :10

• Sequence 1: NP_476753.1
• Gene: Su(dx) / 33379
• FlyBaseID: FBgn0003557
• Length: 949
• Species: Drosophila melanogaster
• Sequence 2: XP_047280612.1
• Gene: HECTD2 / 143279
• HGNCID: 26736
• Length: 781
• Species: Homo sapiens
• Alignment Length: 370
• Identity: 120/370 - (32%)
• Similarity: 191/370 - (51%)
• Gaps: 30/370 - (8%)

  Fly   594 IKITVTRQTLFEDSYHQIMRLPAYELRRRLYIIFRGEEGLDYGGVSREWFFLLSHEVLNPMYCLF 658
            :.:.|.|..|..||..::.|..| :|:::|.:.|.||.|||.||:::|||.||..::.:|.|.:|
Human   422 LNMKVRRTHLVSDSLDELTRKRA-DLKKKLKVTFVGEAGLDMGGLTKEWFLLLIRQIFHPDYGMF 485

  Fly   659 EYANKNNYSLQINPASYVNPDHLQYFKFIGRFIAMALYHGRFIYSGFTMPFYKRMLNK------- 716
            .| :|:::   .:..|....|:...|:.:|..:.:|:|:...:...|....||::|:.
Human   486 TY-HKDSH---CHWFSSFKCDNYSEFRLVGILMGLAVYNSITLDIRFPPCCYKKLLSPPIIPSDQ 546

  Fly   717 -------KLTIKDIETIDPEFYNSL--IWVKDNNIDECGLELWFSVDFEVLGQIIHHELKENGEK 772
                   .:|:.|:..|.||..:.|  :...:.|::| .....|.|..|..|.|..:.||..|:|
Human   547 NIPVGICNVTVDDLCQIMPELAHGLSELLSHEGNVEE-DFYSTFQVFQEEFGIIKSYNLKPGGDK 610

  Fly   773 ERVTEENKEEYITLMTEWRMTRGIEQQTKTFLEGFNEVVPLEWLKYFDERELELILCGMQDVDVE 837
            ..||.:|::||:.|.|::.:.:.|.:|...|..||:.|.....|......|:|:::||..|:|:.
Human   611 ISVTNQNRKEYVQLYTDFLLNKSIYKQFAAFYYGFHSVCASNALMLLRPEEVEILVCGSPDLDMH 675

  Fly   838 DWQRNTIYRHYNRNSKQVVWFWQFVRETDNEKRARLLQFVTGTCRVPVGGFAELMGSNGPQRFCI 902
            ..||:|.|..|.:....:.:||..|.....:.:.:||.|.||:.||||||.|:|       .|.|
Human   676 ALQRSTQYDGYAKTDLTIKYFWDVVLGFPLDLQKKLLHFTTGSDRVPVGGMADL-------NFKI 733

  Fly   903 EKVGKET-WLPRSHTCFNRLDLPPYKSYDQLVEKLTFAIEETEGF 946
            .|....| .||.:|||||:|.||||||...|.:||...|..:|||
Human   734 SKNETSTNCLPVAHTCFNQLCLPPYKSKKDLKQKLIIGISNSEGF 778

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Su(dx)	NP_476753.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988
		WW	364..396	CDD:197736
		HUL4	<395..946	CDD:227354	118/368 (32%)
HECTD2	XP_047280612.1	HECTc	422..779	CDD:238033	120/370 (32%)