DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Su(dx) and Magi2

DIOPT Version :9

Sequence 1:	NP_001259898.1	Gene:	Su(dx) / 33379	FlyBaseID:	FBgn0003557	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	NP_446073.2	Gene:	Magi2 / 113970	RGDID:	621855	Length:	1277	Species:	Rattus norvegicus

Alignment Length:	337	Identity:	70/337 - (20%)
Similarity:	123/337 - (36%)	Gaps:	87/337 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   243 PNGGGDHRRSTQAPPVWEQQQQQSQNQQQPLRMVNGSGAAV-PQTAPYPQQPPAPALARPLTQVY 306
            |:..|..:|:.....:.:...:..:.:::...:|||:|..: |:::.:..:....:
  Rat   209 PSAEGKRKRNKSVTNMEKASIEPPEEEEEERPVVNGNGVVITPESSEHEDKSAGAS--------- 264

  Fly   307 GALPENTQPAAVYLPAGGGAAVGPPGVAGPPIEQPGVGLPVSQSTDPQLQTQP---ADDEPLPAG 368
            |..|....||.||                   .||.   .:....|....|:|   .|.:|||..
  Rat   265 GETPSQPYPAPVY-------------------SQPE---ELKDQMDDTKSTKPEENEDSDPLPDN 307

  Fly   369 WEIRLDQYGRRYYVDHNTRSTYWEKP--------------TPLPPGWEIRKDGRGRVYYVDHNTR 419
            ||:...:.|..|::||||::|.|..|              ..||.|||...|.....|||||..|
  Rat   308 WEMAYTEKGEVYFIDHNTKTTSWLDPRLAKKAKPAEECKENELPYGWEKIDDPIYGTYYVDHINR 372

  Fly   420 KTTWQRPNSERLMHFQ-----HWQ-GQRAHVVSQGNQRYLYSQQQQQPTAVTAQVT--------- 469
            :|.::.|..|.....|     |.: |.:........::.|:::...|........|
  Rat   373 RTQFENPVLEAKRKLQQHNMPHTELGTKPLQAPGFREKPLFTRDASQLKGTFLSTTLKKSNMGFG 437

  Fly   470 -------QDDE--DALGPLPDG---WEKKIQSDNRVYFVN--------HKNRTTQWEDPRTQGQE 514
                   :.||  .....:|||   .:.|:::.:.:.::|        |.:....::.... ||.
  Rat   438 FTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHTHADVVKLFQSVPI-GQS 501

  Fly   515 VSLI--NEGPLP 524
            |:|:  ...|||
  Rat   502 VNLVLCRGYPLP 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(dx)	NP_001259898.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988
		WW	364..396	CDD:197736	14/45 (31%)
		WW	397..426	CDD:278809	13/28 (46%)
		WW	478..509	CDD:197736	6/41 (15%)
		WW	522..554	CDD:197736	3/3 (100%)
		HECTc	594..946	CDD:238033
		HECTc	620..946	CDD:214523
Magi2	NP_446073.2	PDZ_signaling	22..96	CDD:238492
		GuKc	118..291	CDD:214504	17/112 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	205..308		23/129 (18%)
		Interaction with DDN. /evidence=ECO:0000250	302..381		28/78 (36%)
		WW	304..333	CDD:395320	12/28 (43%)
		WW	350..381	CDD:197736	14/30 (47%)
		PDZ	428..509	CDD:214570	13/81 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	556..575
		PDZ	602..683	CDD:214570
		MAGI_u5	687..758	CDD:406953
		PDZ	775..861	CDD:214570
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	869..913
		PDZ_signaling	920..1007	CDD:238492
		PRK10263	<1007..>1135	CDD:236669
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1011..1130
		PDZ_signaling	1140..1220	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810