DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Su(dx) and WWP2

DIOPT Version :9

Sequence 1:	NP_001259898.1	Gene:	Su(dx) / 33379	FlyBaseID:	FBgn0003557	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	NP_001257383.1	Gene:	WWP2 / 11060	HGNCID:	16804	Length:	870	Species:	Homo sapiens

Alignment Length:	942	Identity:	503/942 - (53%)
Similarity:	624/942 - (66%)	Gaps:	102/942 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 SSSGAGASGSANQGYHQLSVTIEEASLRNNGFLKP--NPYVELLID---SKSKRKTDLVKNSYLP 93
            |||.||.:....:....|.|...:..:.|.   :|  |.|||:.:|   |::|:....:.:|.|
Human     5 SSSRAGVALPFEKSQLTLKVVSAKPKVHNR---QPRINSYVEVAVDGLPSETKKTGKRIGSSEL- 65

  Fly    94 KWNEEFTVLITPNSTLHFKVLDHSSFRKDAMLGERIINLAHILQHYNGRCEFLELTIDLFVTSKS 158
            .|||...:.:|..|.|..||....:.|.: :||...:||:::|::..|:.|.::||::|...:|.
Human    66 LWNEIIILNVTAQSHLDLKVWSCHTLRNE-LLGTASVNLSNVLKNNGGKMENMQLTLNLQTENKG 129

  Fly   159 DNRQTKSGELVAILNGLKLDMSKLQIQPVAGQQNGNPPVQAVNPSVVSDAAAGRSCMIYGGVRAR 223
            .  ....|||...|:|..:|:             ||.|    |.|.::|.             ::
Human   130 S--VVSGGELTIFLDGPTVDL-------------GNVP----NGSALTDG-------------SQ 162

  Fly   224 MRLRSSSGNSNGGETRSPLPN----GGGD--HRRS----TQAPPVWEQQQQQSQNQQQPLR---- 274
            :..|.|||.:...|.|...|:    ||..  ||.|    ...|...||........:||::
Human   163 LPSRDSSGTAVAPENRHQPPSTNCFGGRSRTHRHSGASARTTPATGEQSPGARSRHRQPVKNSGH 227

  Fly   275 --MVNGSGAAVPQTAPYPQQPPAPALARPLTQVYGALPENTQPAAVYLPAGGGAAVGPPGVAGPP 337
              :.||:....|.||..|::|....:..|........|   .|....|||....|.|
Human   228 SGLANGTVNDEPTTATDPEEPSVVGVTSPPAAPLSVTP---NPNTTSLPAPATPAEG-------- 281

  Fly   338 IEQPGVGLPVSQSTDPQLQTQPADDEPLPAGWEIRLDQYGRRYYVDHNTRSTYWEKPTPLPPGWE 402
             |:|      |.|...||.......:.||||||.|....||.|||||||::|.||:  |||||||
Human   282 -EEP------STSGTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWER--PLPPGWE 337

  Fly   403 IRKDGRGRVYYVDHNTRKTTWQRPNSERLMHFQHWQGQRAHVVSQG-----NQRYLYSQQQQQPT 462
            .|.|.|||.||||||||.||||||.:|.:.:::.||.||..:  ||     :||:||    |..:
Human   338 KRTDPRGRFYYVDHNTRTTTWQRPTAEYVRNYEQWQSQRNQL--QGAMQHFSQRFLY----QSSS 396

  Fly   463 AVTAQVTQDDEDALGPLPDGWEKKIQSDNRVYFVNHKNRTTQWEDPRTQGQEVSLINEGPLPPGW 527
            |.|      |.|.|||||.||||: |.:.|||:|||..||||||||||||    :|.|..|||||
Human   397 AST------DHDPLGPLPPGWEKR-QDNGRVYYVNHNTRTTQWEDPRTQG----MIQEPALPPGW 450

  Fly   528 EIRYTAAGERFFVDHNTRRTTFEDPRPGAPKGAKGVYGVPRAYERSFRWKLSQFRYLCQSNALPS 592
            |::||:.|.|:|||||||.|||:|||||...|.|  .|.|.||:||||||..|||:||.||||||
Human   451 EMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTK--QGSPGAYDRSFRWKYHQFRFLCHSNALPS 513

  Fly   593 HIKITVTRQTLFEDSYHQIMRLPAYELRRRLYIIFRGEEGLDYGGVSREWFFLLSHEVLNPMYCL 657
            |:||:|:||||||||:.|||.:..|:||||||||.||||||||||::||||||||||||||||||
Human   514 HVKISVSRQTLFEDSFQQIMNMKPYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCL 578

  Fly   658 FEYANKNNYSLQINPASYVNPDHLQYFKFIGRFIAMALYHGRFIYSGFTMPFYKRMLNKKLTIKD 722
            ||||.||||.|||||||.:|||||.||:|||||||||||||:||.:|||:|||||||||:.|:||
Human   579 FEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKFIDTGFTLPFYKRMLNKRPTLKD 643

  Fly   723 IETIDPEFYNSLIWVKDNNIDECGLELWFSVDFEVLGQIIHHELKENGEKERVTEENKEEYITLM 787
            :|:||||||||::|:|:||::||||||:|..|.|:||::..|||||.||..|||||||||||.|:
Human   644 LESIDPEFYNSIVWIKENNLEECGLELYFIQDMEILGKVTTHELKEGGESIRVTEENKEEYIMLL 708

  Fly   788 TEWRMTRGIEQQTKTFLEGFNEVVPLEWLKYFDERELELILCGMQDVDVEDWQRNTIYRHYNRNS 852
            |:||.|||:|:|||.||:|||||.|||||:||||:||||:|||||::|:.|||::||||||.:||
Human   709 TDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMSDWQKSTIYRHYTKNS 773

  Fly   853 KQVVWFWQFVRETDNEKRARLLQFVTGTCRVPVGGFAELMGSNGPQRFCIEKVGKETWLPRSHTC 917
            ||:.||||.|:|.|||||.|||||||||||:||||||||:||||||:|||:||||||||||||||
Human   774 KQIQWFWQVVKEMDNEKRIRLLQFVTGTCRLPVGGFAELIGSNGPQKFCIDKVGKETWLPRSHTC 838

  Fly   918 FNRLDLPPYKSYDQLVEKLTFAIEETEGFCQE 949
            ||||||||||||:||.|||.:||||||||.||
Human   839 FNRLDLPPYKSYEQLREKLLYAIEETEGFGQE 870

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(dx)	NP_001259898.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988	36/129 (28%)
		WW	364..396	CDD:197736	19/31 (61%)
		WW	397..426	CDD:278809	23/28 (82%)
		WW	478..509	CDD:197736	21/30 (70%)
		WW	522..554	CDD:197736	22/31 (71%)
		HECTc	594..946	CDD:238033	271/351 (77%)
		HECTc	620..946	CDD:214523	255/325 (78%)
WWP2	NP_001257383.1	C2_E3_ubiquitin_ligase	17..142	CDD:175988	36/131 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	151..299		42/182 (23%)
		Atrophin-1	<164..343	CDD:331285	66/198 (33%)
		WW	302..331	CDD:306827	19/30 (63%)
		WW	332..361	CDD:306827	23/28 (82%)
		WW	407..435	CDD:306827	19/28 (68%)
		WW	447..477	CDD:238122	21/29 (72%)
		HECTc	516..868	CDD:238033	272/351 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	529	1.000	Domainoid score	I285
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	961	1.000	Inparanoid score	I330
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52003
OrthoDB	1	1.010	-	-		D126241at33208
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	1	1.000	-	-		otm41953
orthoMCL	1	0.900	-	-		OOG6_100256
Panther	1	1.100	-	-	O	PTHR11254
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2273
SonicParanoid	1	1.000	-	-		X898
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.870