Protein Alignment Su(dx) and WWP1

DIOPT Version :9

• Sequence 1: NP_001259898.1
• Gene: Su(dx) / 33379
• FlyBaseID: FBgn0003557
• Length: 949
• Species: Drosophila melanogaster
• Sequence 2: NP_008944.1
• Gene: WWP1 / 11059
• HGNCID: 17004
• Length: 922
• Species: Homo sapiens
• Alignment Length: 1001
• Identity: 511/1001 - (51%)
• Similarity: 638/1001 - (63%)
• Gaps: 159/1001 - (15%)

  Fly    27 SASPTPTSSSGAGASGSANQGYHQLSVTIEEASL-RNNGFLKPNPYVELLIDSKSKRKTDLVKNS 90
            :|||...:|:.       :.|..||.||:..|.| |...:.....|.|:::|.:. .||....:|
Human     3 TASPRSDTSNN-------HSGRLQLQVTVSSAKLKRKKNWFGTAIYTEVVVDGEI-TKTAKSSSS 59

  Fly    91 YLPKWNEEFTVLITPNSTLHFKVLDHSSFRKDAMLGERIINLAHILQHYNGRCEFLELTIDLFVT 155
            ..|||:|:.||.:||.:||.|:|..|.:.:.||:||:..|:|...|..:|.:.|.::..:.|.:.
Human    60 SNPKWDEQLTVNVTPQTTLEFQVWSHRTLKADALLGKATIDLKQALLIHNRKLERVKEQLKLSLE 124

  Fly   156 SKSDNRQTKSGELVAILNGLKLDMSKL----QIQPVAGQQNGNPPVQAVNPSVVSDAAAGRSCMI 216
            :|:...||  |||..:|:||.::...:    ....:..|:||:...:...||
Human   125 NKNGIAQT--GELTVVLDGLVIEQENITNCSSSPTIEIQENGDALHENGEPS------------- 174

  Fly   217 YGGVRARMRLRSSSGNSNGGETRSPLPNGGGDHRRSTQAPPVWEQQQQQSQNQQQPLRMVNGSG- 280
             ....||:.:..::|..|...|.:.:.|....:                         :|||..
Human   175 -ARTTARLAVEGTNGIDNHVPTSTLVQNSCCSY-------------------------VVNGDNT 213

  Fly   281 -AAVPQTAPYPQQPPAPALARPLTQVYGALPENTQPA--------AVYLPAGGGAAVGPPGVA-- 334
             ::..|.|..|:..|||   :||.         ::||        :.:.|....:..|.|.|:
Human   214 PSSPSQVAARPKNTPAP---KPLA---------SEPADDTVNGESSSFAPTDNASVTGTPVVSEE 266

  Fly   335 --------GPPIEQPGVGLPVSQ------------STDPQLQT---------------------- 357
                    ...:|.|    ||.:            ||..:|::
Human   267 NALSPNCTSTTVEDP----PVQEILTSSENNECIPSTSAELESEARSILEPDTSNSRSSSAFEAA 327

  Fly   358 ---QP-------------ADDEPLPAGWEIRLDQYGRRYYVDHNTRSTYWEKPTPLPPGWEIRKD 406
               ||             |:.|.||:|||.|.|.:||.||||||||:|.||:|.|||||||.|.|
Human   328 KSRQPDGCMDPVRQQSGNANTETLPSGWEQRKDPHGRTYYVDHNTRTTTWERPQPLPPGWERRVD 392

  Fly   407 GRGRVYYVDHNTRKTTWQRPNSERLMHFQHWQGQRAHV---VSQGNQRYLYSQQQQQPTAVTAQV 468
            .|.||||||||||.||||||..|.:.:|:.||.||..:   :.|.|||||||          |.:
Human   393 DRRRVYYVDHNTRTTTWQRPTMESVRNFEQWQSQRNQLQGAMQQFNQRYLYS----------ASM 447

  Fly   469 TQDDEDALGPLPDGWEKKIQSDNRVYFVNHKNRTTQWEDPRTQGQEVSLINEGPLPPGWEIRYTA 533
            ...:.|..||||.||||::.|.:|||||||..:|||||||||||    |.||.|||.|||||||.
Human   448 LAAENDPYGPLPPGWEKRVDSTDRVYFVNHNTKTTQWEDPRTQG----LQNEEPLPEGWEIRYTR 508

  Fly   534 AGERFFVDHNTRRTTFEDPRPGAPKGAKGVYGVPRAYERSFRWKLSQFRYLCQSNALPSHIKITV 598
            .|.|:|||||||.|||:|||.|.....||  |...||||.|||||:.|||||||||||||:||.|
Human   509 EGVRYFVDHNTRTTTFKDPRNGKSSVTKG--GPQIAYERGFRWKLAHFRYLCQSNALPSHVKINV 571

  Fly   599 TRQTLFEDSYHQIMRLPAYELRRRLYIIFRGEEGLDYGGVSREWFFLLSHEVLNPMYCLFEYANK 663
            :||||||||:.|||.|..|:||||||:||||||||||||::||||||||||||||||||||||.|
Human   572 SRQTLFEDSFQQIMALKPYDLRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGK 636

  Fly   664 NNYSLQINPASYVNPDHLQYFKFIGRFIAMALYHGRFIYSGFTMPFYKRMLNKKLTIKDIETIDP 728
            |||.|||||||.:|||||.||.||||||||||:||:||.:||::|||||||:|||||||:|:||.
Human   637 NNYCLQINPASTINPDHLSYFCFIGRFIAMALFHGKFIDTGFSLPFYKRMLSKKLTIKDLESIDT 701

  Fly   729 EFYNSLIWVKDNNIDECGLELWFSVDFEVLGQIIHHELKENGEKERVTEENKEEYITLMTEWRMT 793
            ||||||||::||||:|||||::||||.|:||::..|:||..|....||||||:|||.||||||.:
Human   702 EFYNSLIWIRDNNIEECGLEMYFSVDMEILGKVTSHDLKLGGSNILVTEENKDEYIGLMTEWRFS 766

  Fly   794 RGIEQQTKTFLEGFNEVVPLEWLKYFDERELELILCGMQDVDVEDWQRNTIYRHYNRNSKQVVWF 858
            ||:::|||.||:||||||||:||:||||:|||::|||||:||:.||||||:||||.|||||::||
Human   767 RGVQEQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLADWQRNTVYRHYTRNSKQIIWF 831

  Fly   859 WQFVRETDNEKRARLLQFVTGTCRVPVGGFAELMGSNGPQRFCIEKVGKETWLPRSHTCFNRLDL 923
            ||||:|||||.|.|||||||||||:|:|||||||||||||:||||||||:|||||||||||||||
Human   832 WQFVKETDNEVRMRLLQFVTGTCRLPLGGFAELMGSNGPQKFCIEKVGKDTWLPRSHTCFNRLDL 896

  Fly   924 PPYKSYDQLVEKLTFAIEETEGFCQE 949
            ||||||:||.|||.|||||||||.||
Human   897 PPYKSYEQLKEKLLFAIEETEGFGQE 922

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Su(dx)	NP_001259898.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988	42/125 (34%)
		WW	364..396	CDD:197736	21/31 (68%)
		WW	397..426	CDD:278809	23/28 (82%)
		WW	478..509	CDD:197736	21/30 (70%)
		WW	522..554	CDD:197736	24/31 (77%)
		HECTc	594..946	CDD:238033	274/351 (78%)
		HECTc	620..946	CDD:214523	257/325 (79%)
WWP1	NP_008944.1	C2_E3_ubiquitin_ligase	17..140	CDD:175988	42/125 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	210..388		52/193 (27%)
		HUL4	<307..922	CDD:227354	424/630 (67%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159622
Domainoid	1	1.000	529	1.000	Domainoid score	I285
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H21385
Inparanoid	1	1.050	961	1.000	Inparanoid score	I330
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52003
OrthoDB	1	1.010	-	-		D126241at33208
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	1	1.000	-	-		otm41953
orthoMCL	1	0.900	-	-		OOG6_100256
Panther	1	1.100	-	-	LDO	PTHR11254
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X898
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.770