Protein Alignment Su(dx) and Wwp1

DIOPT Version :10

• Sequence 1: NP_476753.1
• Gene: Su(dx) / 33379
• FlyBaseID: FBgn0003557
• Length: 949
• Species: Drosophila melanogaster
• Sequence 2: NP_796301.2
• Gene: Wwp1 / 107568
• MGIID: 1861728
• Length: 918
• Species: Mus musculus
• Alignment Length: 990
• Identity: 515/990 - (52%)
• Similarity: 637/990 - (64%)
• Gaps: 141/990 - (14%)

  Fly    27 SASPTPTSSSGAGASGSANQGYHQLSVTIEEASL-RNNGFLKPNPYVELLIDSKSKRKTDLVKNS 90
            :|||...:|       ..:.|..||.||:..|.| |...:.....|.|:::|.:.| ||....:|
Mouse     3 TASPRSDTS-------DIHSGRLQLKVTVSSAKLKRKKNWFGTAIYTEVIVDGEVK-KTAKSSSS 59

  Fly    91 YLPKWNEEFTVLITPNSTLHFKVLDHSSFRKDAMLGERIINLAHILQHYNGRCEFLELTIDLFVT 155
            ..|||:|:..|.:||.:||.|:|..|.:.:.||:||:..::|..:|..:|.:.|.::..:.|.:.
Mouse    60 SNPKWDEQLIVNVTPQTTLEFRVWSHHTLKADALLGKATVDLKQVLLTHNRKLEKVKEQLKLSLE 124

  Fly   156 SKSDNRQTKSGELVAILNGLKLDM----SKLQIQPVAGQQNGN------PPVQAVNPSVVSDAAA 210
            :|:...||  |||..:|:||.::.    ::....|:..||||:      .|.....|
Mouse   125 NKNGIVQT--GELTVVLDGLVIEQEPVTNRSSSPPIEIQQNGDALHENGDPATRTTP-------- 179

  Fly   211 GRSCMIYGGVRARMRLRSSSGNSNGGETRSPLPNGGGDHRRSTQAPPVWEQQQQQSQNQQQPLRM 275
                        |:.:..:.|..|...|.:.:||....|                         :
Mouse   180 ------------RLPVEGTIGIDNHVSTNTVVPNSCCSH-------------------------V 207

  Fly   276 VNGSG--AAVPQTAPYPQQPPAPALARPLTQ------VYG----ALPENTQPAAVYLPAGGGAAV 328
            |||..  ::..|.|..|:..|||   :|:|.      |.|    .|.:||......||:....:.
Mouse   208 VNGENTPSSPSQVAARPKNAPAP---KPVTSAPTSDTVNGESSSVLADNTSTMGTLLPSEDTTST 269

  Fly   329 G---PPGVAGPPIEQP---------------GVGLPVSQSTDPQLQT----------QP------ 359
            .   ......||:::|               .||.......||...:          ||
Mouse   270 SNCTSTTTQEPPVQEPPASSEHSECIPSASAEVGPEARSLIDPDSDSRNNSVFDKVRQPEGCVEP 334

  Fly   360 -------ADDEPLPAGWEIRLDQYGRRYYVDHNTRSTYWEKPTPLPPGWEIRKDGRGRVYYVDHN 417
                   .:.|.||:|||.|.|.:||.||||||||:|.||:|.|||||||.|.|.||||||||||
Mouse   335 LRPQSGNTNTEALPSGWEQRKDPHGRTYYVDHNTRTTTWERPQPLPPGWERRVDDRGRVYYVDHN 399

  Fly   418 TRKTTWQRPNSERLMHFQHWQGQRAHV---VSQGNQRYLYSQQQQQPTAVTAQVTQDDEDALGPL 479
            ||.||||||..|.:.:|:.||.||..:   :.|.|||||||          |.:...:.|..|||
Mouse   400 TRTTTWQRPTMESVRNFEQWQSQRNQLQGAMQQFNQRYLYS----------ASMLAAENDPYGPL 454

  Fly   480 PDGWEKKIQSDNRVYFVNHKNRTTQWEDPRTQGQEVSLINEGPLPPGWEIRYTAAGERFFVDHNT 544
            |.||||::.|.:|||||||..:|||||||||||    |.||.|||.|||||||..|.|:||||||
Mouse   455 PPGWEKRVDSTDRVYFVNHNTKTTQWEDPRTQG----LPNEEPLPEGWEIRYTREGVRYFVDHNT 515

  Fly   545 RRTTFEDPRPGAPKGAKGVYGVPRAYERSFRWKLSQFRYLCQSNALPSHIKITVTRQTLFEDSYH 609
            |.|||:|||.|.....||  |...||||||||||:.|||||||||||||:||.|:||||||||:.
Mouse   516 RTTTFKDPRNGKSSVTKG--GPQIAYERSFRWKLAHFRYLCQSNALPSHVKINVSRQTLFEDSFQ 578

  Fly   610 QIMRLPAYELRRRLYIIFRGEEGLDYGGVSREWFFLLSHEVLNPMYCLFEYANKNNYSLQINPAS 674
            |||.|..|:||||||:||||||||||||::||||||||||||||||||||||.||||.|||||||
Mouse   579 QIMALKPYDLRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPAS 643

  Fly   675 YVNPDHLQYFKFIGRFIAMALYHGRFIYSGFTMPFYKRMLNKKLTIKDIETIDPEFYNSLIWVKD 739
            .:|||||.||.||||||||||:||:||.:||::|||||||:|||||||:|:||.||||||||::|
Mouse   644 TINPDHLSYFCFIGRFIAMALFHGKFIDTGFSLPFYKRMLSKKLTIKDLESIDTEFYNSLIWIRD 708

  Fly   740 NNIDECGLELWFSVDFEVLGQIIHHELKENGEKERVTEENKEEYITLMTEWRMTRGIEQQTKTFL 804
            |||:|||||::||||.|:||::..|:||..|....||||||:|||.||||||.:||:::|||.||
Mouse   709 NNIEECGLEMYFSVDMEILGKVTSHDLKLGGSNILVTEENKDEYIGLMTEWRFSRGVQEQTKAFL 773

  Fly   805 EGFNEVVPLEWLKYFDERELELILCGMQDVDVEDWQRNTIYRHYNRNSKQVVWFWQFVRETDNEK 869
            :||||||||:||:||||:|||::|||||:||:.||||||:||||.|||||::||||||:|||||.
Mouse   774 DGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLADWQRNTVYRHYTRNSKQIIWFWQFVKETDNEV 838

  Fly   870 RARLLQFVTGTCRVPVGGFAELMGSNGPQRFCIEKVGKETWLPRSHTCFNRLDLPPYKSYDQLVE 934
            |.|||||||||||:|:|||||||||||||:||||||||:|||||||||||||||||||||:||.|
Mouse   839 RMRLLQFVTGTCRLPLGGFAELMGSNGPQKFCIEKVGKDTWLPRSHTCFNRLDLPPYKSYEQLKE 903

  Fly   935 KLTFAIEETEGFCQE 949
            ||.|||||||||.||
Mouse   904 KLLFAIEETEGFGQE 918

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Su(dx)	NP_476753.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988	41/125 (33%)
		WW	364..396	CDD:197736	21/31 (68%)
		HUL4	<395..946	CDD:227354	399/553 (72%)
Wwp1	NP_796301.2	C2_E3_ubiquitin_ligase	17..140	CDD:175988	41/125 (33%)
		DUF5585	<148..>381	CDD:465521	65/280 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	150..182		8/51 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	209..360		34/153 (22%)
		Required for interaction with and ubiquitination of AMOTL2. Required for interaction with YAP1. /evidence=ECO:0000250|UniProtKB:Q9H0M0	345..527		120/195 (62%)
		Interaction with ERBB4. /evidence=ECO:0000269|PubMed:19561640	345..525		119/193 (62%)
		WW	347..376	CDD:459800	20/28 (71%)
		HUL4	<377..918	CDD:227354	401/556 (72%)