DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Su(dx) and YAP1

DIOPT Version :9

Sequence 1:	NP_001259898.1	Gene:	Su(dx) / 33379	FlyBaseID:	FBgn0003557	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	XP_005271435.1	Gene:	YAP1 / 10413	HGNCID:	16262	Length:	510	Species:	Homo sapiens

Alignment Length:	404	Identity:	103/404 - (25%)
Similarity:	148/404 - (36%)	Gaps:	129/404 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   243 PNGGGD-----HRRSTQAPPVWEQ---QQQQSQNQQQPL--RMVNGSGAAVPQTAP-----YPQ- 291
            |:|.|.     .:.:.||||...|   .:..|:...:.|  .::|...|.||||.|     .|.
Human    30 PSGPGQPAPAATQAAPQAPPAGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRKLPDS 94

  Fly   292 --QPPAP----ALARPLTQVYGAL-PE----NTQPAAVYLPAGGGAAVGPPGVAGPPIEQPGVGL 345
              :||.|    ..|.......||| |:    ::.||::.|.|.....:.|.||...|     ...
Human    95 FFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGP-----AAT 154

  Fly   346 PVSQSTDPQLQTQPADDEPLPAGWEIRLDQYGRRYYVDHNTRSTYWEKPTPLPPGWEIRKDGRGR 410
            |.:|.. .|...:..||.|||||||:.....|:||:::|
Human   155 PTAQHL-RQSSFEIPDDVPLPAGWEMAKTSSGQRYFLNH-------------------------- 192

  Fly   411 VYYVDHNTRKTTWQRPNSERLMHFQHWQGQRAHVVSQGNQRYLYSQQQQQPTAVTAQVTQDD--E 473
               :|   :.||||.|....|                         .|...||.|:...|.:  .
Human   193 ---ID---QTTTWQDPRKAML-------------------------SQMNVTAPTSPPVQQNMMN 226

  Fly   474 DALGPLPDGWEKKIQSDNRVYFVNHKNRTTQWEDPRTQGQEVSLINEGPLPPGWEIRYTAAGERF 538
            .|.||||||||:.:..|..:|::||||:||.|.|||             |.|           ||
Human   227 SASGPLPDGWEQAMTQDGEIYYINHKNKTTSWLDPR-------------LDP-----------RF 267

  Fly   539 FVDHNTR---RTTFEDPRPGAPKGAK-GVYGVPRAYERSFRWKLSQFRYLCQSNALPSHIKITVT 599
            ....|.|   ....:.|.|.||:..: ||.|...:.::. :.:|.|.:.        ...::.:.
Human   268 GKAMNQRISQSAPVKQPPPLAPQSPQGGVMGGSNSNQQQ-QMRLQQLQM--------EKERLRLK 323

  Fly   600 RQTLFEDSYHQIMR 613
            :|.|......|.||
Human   324 QQELLRQVRPQAMR 337

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(dx)	NP_001259898.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988
		WW	364..396	CDD:197736	11/31 (35%)
		WW	397..426	CDD:278809	5/28 (18%)
		WW	478..509	CDD:197736	17/30 (57%)
		WW	522..554	CDD:197736	7/34 (21%)
		HECTc	594..946	CDD:238033	5/20 (25%)
		HECTc	620..946	CDD:214523
YAP1	XP_005271435.1	WW	174..203	CDD:238122	14/60 (23%)
YAP1	XP_005271435.1	WW	232..261	CDD:366073	15/28 (54%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810