DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Su(dx) and HUWE1

DIOPT Version :9

Sequence 1:	NP_001259898.1	Gene:	Su(dx) / 33379	FlyBaseID:	FBgn0003557	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	XP_016884680.1	Gene:	HUWE1 / 10075	HGNCID:	30892	Length:	4501	Species:	Homo sapiens

Alignment Length:	975	Identity:	261/975 - (26%)
Similarity:	408/975 - (41%)	Gaps:	209/975 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 GSASPTPTSSSGAGA------SGSANQGYHQLSVTI------EEASLRNNGFLKPNPYVELLIDS 78
            ||.||...|..|:.:      |....:...||||.:      .|..|.:    ..|..::|....
Human  3679 GSKSPAKVSDGGSSSTDFKMVSSGLTENQLQLSVEVLTSHSCSEEGLED----AANVLLQLSRGD 3739

  Fly    79 KSKRKTDLVKNSYLPKWNEEFTVLITPNSTLHFKVLDHSSFRKDAMLGERIINLAHILQHYN--- 140
            ...|.|.|                         |:|.:.:......|.::|..|...|:.||
Human  3740 SGTRDTVL-------------------------KLLLNGARHLGYTLCKQIGTLLAELREYNLEQ 3779

  Fly   141 ---GRCEFLELTIDLFVTSKSDNRQTK-SGELVAILNGLKLDMSKLQIQPVAGQQN--GNPPVQA 199
               .:||    |:......:...:.|| .|::.:     :.||:: .:..||.|:.  |...:|.
Human  3780 QRRAQCE----TLSPDGLPEEQPQTTKLKGKMQS-----RFDMAE-NVVIVASQKRPLGGRELQL 3834

  Fly   200 VNPSVVSDAAAGRSCMIYGGVRARMRLRSSSGNSN-GGETRSPLPNGGGDHRRSTQA-------- 255
            .:.|:::...:.:...: ..::..::||..:..:| ..:....|.:.|.....|.||
Human  3835 PSMSMLTSKTSTQKFFL-RVLQVIIQLRDDTRRANKKAKQTGRLGSSGLGSASSIQAAVRQLEAE 3898

  Fly   256 -----PPVWEQQQQQSQNQQQPLRMVNGSGAAVPQTAPYPQQPPAPALARPLTQVYGALPENTQP 315
                 ..|.|.|:.:.|.|...........:...:.:|.....|:|:            .::||.
Human  3899 ADAIIQMVREGQRARRQQQAATSESSQSEASVRREESPMDVDQPSPS------------AQDTQS 3951

  Fly   316 AAVYLPAGGGAAVG-------PPGVAGPPIEQPGVGLPVSQSTDPQLQTQPADDEPLPAGWEIRL 373
            .     |..|...|       ||.:                   |.|..|.:.||.    |:: |
Human  3952 I-----ASDGTPQGEKEKEERPPEL-------------------PLLSEQLSLDEL----WDM-L 3987

  Fly   374 DQYGRRYYVDHNTRSTYWEKPTPLPPGWEIRKDGRGRVYYVDHNTRKTTWQRPNSERLMHFQHWQ 438
            .:..:.....|:..:.     ..|.|..|        .:::.|.|.:.:.......|       :
Human  3988 GECLKELEESHDQHAV-----LVLQPAVE--------AFFLVHATERESKPPVRDTR-------E 4032

  Fly   439 GQRAHVVSQGNQRYLYSQQQQQPTAVTAQVTQDDEDALGPLPDGWEKKIQSDNRVYFVNHKNRTT 503
            .|.||:                         :|:...|.|.|                 ....|.
Human  4033 SQLAHI-------------------------KDEPPPLSPAP-----------------LTPATP 4055

  Fly   504 QWEDPRTQGQEVSLINEGPLPPGWEIRYTAAGERFFVDHNTRRTTFED-PRPGAPKGAKGVYGVP 567
            ...||....:..|:.....|||.        .::|.....|.||.... .|......|.|.:.|.
Human  4056 SSLDPFFSREPSSMHISSSLPPD--------TQKFLRFAETHRTVLNQILRQSTTHLADGPFAVL 4112

  Fly   568 RAY---------ERSFRWKLSQFRYLCQSNALPSHIKITVTRQTLFEDSYHQIMRLPAYELRRRL 623
            ..|         .:.||.:|.:.....:...:..|::    |..:|||||.::.|....|::.||
Human  4113 VDYIRVLDFDVKRKYFRQELERLDEGLRKEDMAVHVR----RDHVFEDSYRELHRKSPEEMKNRL 4173

  Fly   624 YIIFRGEEGLDYGGVSREWFFLLSHEVLNPMYCLFEYANKNNYSLQINPASYVNPDHLQYFKFIG 688
            ||:|.||||.|.||:.|||:.::|.|:.||||.||..:..:..:..|||:|:.||:||.||||:|
Human  4174 YIVFEGEEGQDAGGLLREWYMIISREMFNPMYALFRTSPGDRVTYTINPSSHCNPNHLSYFKFVG 4238

  Fly   689 RFIAMALYHGRFIYSGFTMPFYKRMLNKKLTIKDIETIDPEFYNSLIWVKDNNIDECGLELWFSV 753
            |.:|.|:|..|.:...||..|||.:|.|.:...|:|:.|..||..|:::.:|::...|.:|.||.
Human  4239 RIVAKAVYDNRLLECYFTRSFYKHILGKSVRYTDMESEDYHFYQGLVYLLENDVSTLGYDLTFST 4303

  Fly   754 DFEVLGQIIHHELKENGEKERVTEENKEEYITLMTEWRMTRGIEQQTKTFLEGFNEVVPLEWLKY 818
            :.:..|.....:||.||....||||||:||:.|:.:.|||..|.:|...|||||.|::|...:..
Human  4304 EVQEFGVCEVRDLKPNGANILVTEENKKEYVHLVCQMRMTGAIRKQLAAFLEGFYEIIPKRLISI 4368

  Fly   819 FDERELELILCGMQDVDVEDWQRNTIYRHYNRNSKQVVWFWQFVRETDNEKRARLLQFVTGTCRV 883
            |.|:||||::.|:..:|::|.:.||.|..|..||.|:.|||:.:|..|...||:.|||||||.:|
Human  4369 FTEQELELLISGLPTIDIDDLKSNTEYHKYQSNSIQIQWFWRALRSFDQADRAKFLQFVTGTSKV 4433

  Fly   884 PVGGFAELMGSNGPQRFCIEKVGKET-WLPRSHTCFNRLDLPPYKSYDQLVEKLTFAIEE-TEGF 946
            |:.|||.|.|.||.|:|.|.:..:.| .||.:|||||:||||.|:|:::|...|..||:| :|||
Human  4434 PLQGFAALEGMNGIQKFQIHRDDRSTDRLPSAHTCFNQLDLPAYESFEKLRHMLLLAIQECSEGF 4498

Fly 947 946
Human 4499 4498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(dx)	NP_001259898.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988	25/137 (18%)
		WW	364..396	CDD:197736	3/31 (10%)
		WW	397..426	CDD:278809	5/28 (18%)
		WW	478..509	CDD:197736	4/30 (13%)
		WW	522..554	CDD:197736	7/32 (22%)
		HECTc	594..946	CDD:238033	155/353 (44%)
		HECTc	620..946	CDD:214523	147/327 (45%)
HUWE1	XP_016884680.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810