DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Su(dx) and smurf1

DIOPT Version :9

Sequence 1:	NP_001259898.1	Gene:	Su(dx) / 33379	FlyBaseID:	FBgn0003557	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	XP_002931540.1	Gene:	smurf1 / 100491582	XenbaseID:	XB-GENE-479046	Length:	731	Species:	Xenopus tropicalis

Alignment Length:	919	Identity:	296/919 - (32%)
Similarity:	436/919 - (47%)	Gaps:	222/919 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 QLSVTIEEASLRNNGFLKPNPYVELLIDSKSK-RKTDLVKNSYLPKWNEEFTVLITPNSTLHFKV 113
            :|:|...:...:.:.|..|:|:.::::|...: ..||.|||:..||||:.:.:.:....::...:
Frog    16 RLTVLCAKNLAKRDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDPKWNQHYDLYVGKMDSITISI 80

  Fly   114 LDHSSFRKDAMLGERIINLAHILQHYNGRCEFLELTIDLFVTSKSDNRQTKSGELVAILNGLKLD 178
            .:|....|..  |...:....:|                   |.:.:|...:|.       .:||
Frog    81 WNHKKIHKKQ--GAGFLGCVRLL-------------------SNAISRLKDTGY-------QRLD 117

  Fly   179 MSKLQIQPVAGQQNGNPPVQAVNPSVVSDAAAGRSCMIYGGVRARMRLRSSSGNSNGG--ETRSP 241
            :.||                  ||: .|||..|:   |...::.|.|:     .:.|.  :.|..
Frog   118 LCKL------------------NPA-DSDAVRGQ---IVVSLQTRDRI-----GTVGSVVDCRGL 155

  Fly   242 LPNGGGDHRRSTQAPPVWEQQQQQSQNQQQPLRMVNGSGAAVPQTAPYPQQPPAPALARPLTQVY 306
            |.|.|..:..:....|:                     ...:.:.|||...|.|
Frog   156 LDNDGALYEDAGPGRPL---------------------SCFMDEPAPYTDGPGA----------- 188

  Fly   307 GALPENTQPAAVYLPAGGGAAVGPPGVAGPP---IEQPGVGLPVSQSTDPQLQTQPADDEPLPAG 368
                           ||||           |   :|.||        .:.:||.|
Frog   189 ---------------AGGG-----------PCRLVESPG--------QEQRLQAQ---------- 209

  Fly   369 WEIRLDQYGRRYYVDHNTRSTYWEKPTPLPPGWEIRKDGRGRVYYVDHNTRKTTWQRPNSERLMH 433
               ||.....|.:|......::..:...||.|:|.|...:|:||::...|..:||..|...|.::
Frog   210 ---RLRGPEVREHVQTPLNRSHGYQSQDLPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIPRDLN 271

  Fly   434 FQHWQGQRAHVVSQGNQRYLYSQQQQQPTAVTAQVTQDDEDALGPLPDGWEKKIQSDNRVYFVNH 498
                                             .|..||   |||||.|||.:.....|:|||:|
Frog   272 ---------------------------------SVNCDD---LGPLPTGWEVRTTVSGRIYFVDH 300

  Fly   499 KNRTTQWEDPRTQGQEVSLINEGPLPPGWEIRYTAAGERFFVDHNTRRTTFEDPRPGAPKGAKG- 562
            .|||||:.|||.                          ...::|.::   .::|....|..:.|
Frog   301 NNRTTQFTDPRL--------------------------HHIINHQSQ---LKEPNNAIPVQSDGS 336

  Fly   563 -----VYGVPRAYERSFRWKLSQFRY---LCQSNALPSHIKITVTRQTLFEDSYHQIMRLPAYEL 619
                 .:...| |||....||...|:   |.|..|  .|.::.|:|:.:||:||.|||::...:|
Frog   337 LEEGDEFPTQR-YERDLVQKLKVLRHELSLLQPQA--GHCRVEVSREEIFEESYRQIMKMRPKDL 398

  Fly   620 RRRLYIIFRGEEGLDYGGVSREWFFLLSHEVLNPMYCLFEYANKNNYSLQINPASYVNPDHLQYF 684
            ::||.:.||||||||||||:|||.:||.||:|||.|.||:|:..|.|:|||||.|.:|||||.||
Frog   399 KKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYTLQINPDSSINPDHLSYF 463

  Fly   685 KFIGRFIAMALYHGRFIYSGFTMPFYKRMLNKKLTIKDIETIDPEFYNSLIWVKDNNIDECGLEL 749
            .|:||.:.:|::||.:|..|||:||||::|.|.:.:.|:|::|||.:.||:|:.:|:|... |:.
Frog   464 HFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITSV-LDH 527

  Fly   750 WFSVDFEVLGQIIHHELKENGEKERVTEENKEEYITLMTEWRMTRGIEQQTKTFLEGFNEVVPLE 814
            .|.|:....|:::.||||.||:..:||||||:||:.|...||..||||.|.....:||||::|..
Frog   528 TFCVEHNAFGRLLQHELKPNGKNLQVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQH 592

  Fly   815 WLKYFDERELELILCGMQDVDVEDWQRNTIYRHYNRNSKQVVWFWQFVRETDNEKRARLLQFVTG 879
            .||.|:::|||||:.|:..:|:.||:.||..:|...||..|.||||.|...|.|:||||||||||
Frog   593 LLKPFEQKELELIIGGLDKIDISDWKANTRLKHCLANSNIVQWFWQAVESFDEERRARLLQFVTG 657

  Fly   880 TCRVPVGGFAELMGSN---GPQRFCIEKVGKET-WLPRSHTCFNRLDLPPYKSYDQLVEKLTFAI 940
            :.|||:.||..|.||.   ||:.|.|..:...| .||::||||||:|:|||:||::|.|||..|:
Frog   658 STRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAV 722

  Fly   941 EETEGFCQE 949
            |||.||..|
Frog   723 EETSGFAVE 731

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(dx)	NP_001259898.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988	22/123 (18%)
		WW	364..396	CDD:197736	4/31 (13%)
		WW	397..426	CDD:278809	11/28 (39%)
		WW	478..509	CDD:197736	17/30 (57%)
		WW	522..554	CDD:197736	2/31 (6%)
		HECTc	594..946	CDD:238033	180/355 (51%)
		HECTc	620..946	CDD:214523	170/329 (52%)
smurf1	XP_002931540.1	C2_Smurf-like	14..138	CDD:176028	33/171 (19%)
		WW	234..266	CDD:197736	12/31 (39%)
		WW	280..312	CDD:197736	18/31 (58%)
		HECTc	373..728	CDD:238033	180/355 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D167687at2759
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010