DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Su(dx) and hecw2b

DIOPT Version :9

Sequence 1:	NP_001259898.1	Gene:	Su(dx) / 33379	FlyBaseID:	FBgn0003557	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	XP_003197660.3	Gene:	hecw2b / 100331355	ZFINID:	ZDB-GENE-101001-3	Length:	1472	Species:	Danio rerio

Alignment Length:	1361	Identity:	349/1361 - (25%)
Similarity:	507/1361 - (37%)	Gaps:	486/1361 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 VNGAGSASPTPTSSSGAGASGSANQGYHQLSVT-------------IEEASLRNNGFLKPNPYVE 73
            |:||..|:....:....|.:..|.......|||             |....|:...|..|:||::
Zfish   159 VSGALRATTPCITVKNPGVTVGAEGQVDGQSVTEHCRKLVSFTLSDIRAQGLKKGMFFNPDPYLK 223

  Fly    74 LLIDSKSK------------RKTDLVKNSYLPKWN-EEFTVLITPNSTLHFKVLDHSSFRKD--- 122
            :.|....:            |:|.::.|:..|.|: |::|.:......|..:|.|  .|.|.
Zfish   224 MSIQPGKRNGFPTFSHHGQERRTSIISNTTNPVWHGEKYTFVALMTDVLEIEVKD--KFAKSRPI 286

  Fly   123 --AMLGERIINLAHIL--------------------QHYNGRCEF-LELTIDLFVTSKSDNRQTK 164
              ..||:.||.:..:|                    :|.:|:..| :|:|.        :..:..
Zfish   287 IKRFLGQLIIPVQRLLERHTAGDQHVSYTLCRRLPTEHVSGQLHFRVEITF--------NGHEDA 343

  Fly   165 SGELV--AILNGLKLDMSKLQ--IQPV-------------------------------------- 187
            .|.|:  :.:||.....|..:  :|||
Zfish   344 MGSLLGASAMNGDPGSPSDDEDVLQPVSRMVRGPSPTGSEGSLHGDAFRPDECMMDPEEDRLLRD 408

  Fly   188 ---------------------------AGQQNGNPPVQAVNPSVVS------------------- 206
                                       |.:..|:.|:.|.:|.:.|
Zfish   409 GAPDLAEGAPAHTHRQSSLNDYLDAIEAPKPPGDRPLGASSPKLRSSFPTDTRLNAMLHIDSDED 473

  Fly   207 -DAAAGRSCMIYGG------------------VRARMRLRSSSGN-----------SNGGETRSP 241
             :..|.|...:..|                  |:.|.||.|.:.:           |:.|.|:|
Zfish   474 EEGHASRDTALTNGMPRPEGHASSERGKGEVHVKNRERLESEAASSATDTEATASVSSSGTTKS- 537

  Fly   242 LPNGGGDHRRSTQAPPVWEQQQQQSQNQQQPLRMVNGSGAAVPQTAPYPQQPPAPALARPLTQVY 306
             .||||.......|.......|..|..||..||:.:..|||...::.......|||::
Zfish   538 -QNGGGAEGGQEGAAISGGLTQSISSFQQPALRIQDEEGAAPQASSRTEGSSEAPAVS------- 594

  Fly   307 GALPENTQPAAVYL--PAGGGAAVGPPGVAGPPIEQPGVGLPVSQSTDPQLQTQPADD------- 362
                 ....:|:|.  ..||..|...|                .:....::..|..:|
Zfish   595 -----EASASAIYTVNEVGGATATNQP----------------ERMNSSEMTNQEEEDEEIWQRR 638

  Fly   363 ------------EPLPAGWEIR--LDQYGRRYYVDHNTR---------------------STYWE 392
                        |.:..|.|:|  .|:.......|..|.                     |.|..
Zfish   639 RSLQASGNESQAEAMELGNEVRRTADEAQAALITDGETGACAQVNGHQPMRSLPSVRHDISRYQR 703

  Fly   393 KPTPLPPGWEIRKDGRGRVYYVDHNTRKTTWQRPNSERLMHFQHWQGQRAHVVSQG---NQRYLY 454
            ...||||.||.|.|..||::||||..|.||||||.:.......    ||::.:.|.   |:||
Zfish   704 VDEPLPPNWEARIDSHGRIFYVDHVNRTTTWQRPTAPPAPQVL----QRSNSIQQMEQLNRRY-- 762

  Fly   455 SQQQQQPTAVTAQVTQDDEDALGP------------LP----DGWEKKIQSDNRV---------- 493
               |.....:|.:.|::....:.|            :|    ||......|.:|:
Zfish   763 ---QSIRRTITNERTEEQAAEMPPDDLTTSDLLHHSIPEYRRDGVVGPASSRSRLTLLLQSPSAK 824

  Fly   494 -------YFVNHKNRTT----------------------QWEDPRTQGQEVSLIN-----EGPLP 524
                   :.|.|.|.:.                      .:|..:.....|:.:|     :..||
Zfish   825 FLTSPDFFTVLHSNPSAYRMFTSNTCLKHMISKVRRDAHHFERYQHNRDLVAFLNMFANKQLDLP 889

  Fly   525 PGWEIRYTAAGERFFVDHNTRRTTF----------------------------------EDPRPG 555
            .|||:::...|:.||||||.|.|||                                  :|||..
Zfish   890 RGWEMKHDHTGKPFFVDHNCRATTFIDPRLPLQSARPSSLLAHRQHLSRQRSHSAGEVGDDPRHA 954

  Fly   556 AP--------------------------------------------------------------- 557
            .|
Zfish   955 GPAVLPRPSNTFTANRNQCQDLVPVAYNEKIVAFLRQPNIFDILQERQPELIRNHSLREKVQFIR 1019

  Fly   558 -KGAKGV----------------------YGVPRA------------------------------ 569
             :||.|:                      |..|.|
Zfish  1020 NEGASGLARLSSDADLVILLSLFEEEVMSYVPPHALLHPSYCQSPRGSPVSSPQNSPGTQRANAR 1084

  Fly   570 ----YERSFRWKLSQFRYLCQSNAL---PSHIKITVTRQTLFEDSYHQIMRLPAYELRR-RLYII 626
                |:|.|..||..|....::...   |..:|:.:.|..|.||:::|||.....:|:| :||:.
Zfish  1085 APAPYKRDFEAKLRNFYRKLETKGYGQGPGKVKLIIRRDHLLEDAFNQIMCYSRKDLQRSKLYVS 1149

  Fly   627 FRGEEGLDYGGVSREWFFLLSHEVLNPMYCLFEYANKNNYSLQINPASYVNPDHLQYFKFIGRFI 691
            |.|||||||.|.|||:|||:|.|:.||.|.||||:..:.|::||:|.|....:|.::|:|.||.:
Zfish  1150 FVGEEGLDYSGPSREFFFLVSRELFNPYYGLFEYSANDTYTVQISPMSAFVDNHHEWFRFSGRIL 1214

  Fly   692 AMALYHGRFIYSGFTMPFYKRMLNKKLTIKDIETIDPEFYNSLIWVKDNNIDECGLELWFSVDFE 756
            .:||.|...:.:.||.||||.:|.....:.|:|.:|.||:.||.|:|||:|::. |:|.|:|:.|
Zfish  1215 GLALIHQYLLDAFFTRPFYKGLLRIPCDLSDLEYLDEEFHQSLQWMKDNDIEDM-LDLTFTVNEE 1278

  Fly   757 VLGQIIHHELKENGEKERVTEENKEEYITLMTEWRMTRGIEQQTKTFLEGFNEVVPLEWLKYFDE 821
            |.|||...|||..|....|:|:||:|||..|.:||:.||:.|||::.:.||.|||....:..||.
Zfish  1279 VFGQITERELKPGGANIPVSEKNKKEYIERMVKWRIERGVVQQTESLVRGFYEVVDARLVSVFDA 1343

  Fly   822 RELELILCGMQDVDVEDWQRNTIYR-HYNRNSKQVVWFWQFVRETDNEKRARLLQFVTGTCRVPV 885
            |||||::.|..::|:.||:.||.|| .|:.|...:.|||..|...:||:|.|||||||||..:|.
Zfish  1344 RELELVIAGTAEIDLGDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLRLLQFVTGTSSIPY 1408

  Fly   886 GGFAELMGSNGPQRFCIEKVGKETWLPRSHTCFNRLDLPPYKSYDQLVEKLTFAIEETEGF 946
            .|||.|.|||||:|||:||.||.|.|||:||||||||||||.|:..|.||:..|:|||..|
Zfish  1409 EGFASLRGSNGPRRFCVEKWGKITSLPRAHTCFNRLDLPPYPSFSMLYEKMLTAVEETSTF 1469

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(dx)	NP_001259898.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988	34/178 (19%)
		WW	364..396	CDD:197736	8/54 (15%)
		WW	397..426	CDD:278809	18/28 (64%)
		WW	478..509	CDD:197736	10/85 (12%)
		WW	522..554	CDD:197736	18/65 (28%)
		HECTc	594..946	CDD:238033	175/353 (50%)
		HECTc	620..946	CDD:214523	166/327 (51%)
hecw2b	XP_003197660.3	HECW_N	58..177	CDD:318711	4/17 (24%)
		C2_NEDL1-like	198..334	CDD:176073	27/137 (20%)
		LGT	<491..633	CDD:320995	34/171 (20%)
		WW	708..737	CDD:306827	18/28 (64%)
		WW	887..919	CDD:197736	16/31 (52%)
		HECTc	1117..1470	CDD:238033	176/354 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910