Protein Alignment Su(dx) and itcha

DIOPT Version :10

• Sequence 1: NP_476753.1
• Gene: Su(dx) / 33379
• FlyBaseID: FBgn0003557
• Length: 949
• Species: Drosophila melanogaster
• Sequence 2: NP_001274024.1
• Gene: itcha / 100331274
• ZFINID: ZDB-GENE-120919-4
• Length: 851
• Species: Danio rerio
• Alignment Length: 923
• Identity: 480/923 - (52%)
• Similarity: 604/923 - (65%)
• Gaps: 98/923 - (10%)

  Fly    50 QLSVTIEEASLRNN--GFLKPNPYVELLIDSKSKRKTDLVKNSYLPKWNEEFTVLITPNSTLHFK 112
            ||.:|:..|.||.|  .:..|:||||:.:|.:|| ||:...|::.|||.:..||::||.|.|.|:
Zfish     4 QLQITVLSAKLRENKKNWFGPSPYVEVFVDGQSK-KTEKCTNTHSPKWKQSLTVIVTPFSKLIFR 67

  Fly   113 VLDHSSFRKDAMLGERIINLAHILQHYNGR-CEFLELTIDLFVTSKSDNRQTKSGELVAILNGLK 176
            |..|.:.:.|.:||...:.::..|:..|.: ||.:: |:.|   |....|..:.|:|...|:||:
Zfish    68 VWSHQTLKADILLGVASLEVSETLKANNMKICEVVQ-TLQL---SSDRGRSEQVGDLSLCLDGLQ 128

  Fly   177 LDMSKLQIQPVAGQQNGNPPVQAVNPSVVSDAAAGRSCMIYGGVRARMRLRSSSGNSNGGETRSP 241
            :|....    .:.:|..|..|.            |.|.:....:|:|     .|..|:.....:|
Zfish   129 VDAETF----ASEEQKHNAVVN------------GESRLNGDAIRSR-----DSSPSSDITDDAP 172

  Fly   242 LPNGGGDHRRSTQAPPVWEQQQQQSQNQQQPLRMVNGSGAAVPQT----APYPQQPPAPALARPL 302
            ||||                            ..|..|.:|.|.|    ||.|.:|..|..|.|.
Zfish   173 LPNG----------------------------HAVGSSASASPSTGALRAPRPLRPQRPPPASPH 209

  Fly   303 TQVYGALPENTQPAAVYLPAGGGAAVGP---PGVA--GPPIEQ---PGVGLPVSQSTDPQLQTQP 359
            ...     .:|..:....|..|.:|..|   |.|.  |....|   .|.|...:....|.....|
Zfish   210 KHT-----SSTASSTGSTPTHGSSAPSPEMSPRVCVNGETESQGSSSGSGSNQAPRASPTPPRAP 269

  Fly   360 A-DDEPLPAGWEIRLDQYGRRYYVDHNTRSTYWEKPTPLPPGWEIRKDGRGRVYYVDHNTRKTTW 423
            | .:.|||.|||.|.||.||.|||||..:.|.||:|.|||||||.|.|..||||||||..|.|||
Zfish   270 AITNGPLPPGWEQRADQNGRVYYVDHIEKRTTWERPEPLPPGWERRLDPMGRVYYVDHINRTTTW 334

  Fly   424 QRPNSERLMHFQHWQGQRAHVVSQG-----NQRYLYS-QQQQQPTAVTAQVTQDDEDALGPLPDG 482
            |||..|.:.:::.||.||:.:  ||     |||::|. |:|..|||      ..:.|.|||||.|
Zfish   335 QRPTLESVRNYEEWQNQRSQL--QGAMQRFNQRFIYGLQEQLAPTA------NKEFDPLGPLPSG 391

  Fly   483 WEKKIQSDNRVYFVNHKNRTTQWEDPRTQGQEVSLINEGPLPPGWEIRYTAAGERFFVDHNTRRT 547
            |||:..|:.|:|||:|..|:||||||||||    |:||.|||.|||:|:|..|..:|||||.|.|
Zfish   392 WEKRTDSNRRMYFVHHPTRSTQWEDPRTQG----LLNEKPLPEGWEMRFTVDGIPYFVDHNRRTT 452

  Fly   548 TFEDPRPGAPKGAKGVYGVPR-AYERSFRWKLSQFRYLCQSNALPSHIKITVTRQTLFEDSYHQI 611
            |:.|||.|......|    |: .|.|.|:.|:..||:.||..::|.||||.|:|:||||||:.||
Zfish   453 TYIDPRTGKSSLENG----PQITYVRDFKAKVHYFRFWCQQLSMPQHIKIHVSRKTLFEDSFQQI 513

  Fly   612 MRLPAYELRRRLYIIFRGEEGLDYGGVSREWFFLLSHEVLNPMYCLFEYANKNNYSLQINPASYV 676
            |.....:|||||:|||.||||||||||:||||||||||||||||||||||.|:||.|||||||.:
Zfish   514 MGCHPQDLRRRLWIIFPGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASSI 578

  Fly   677 NPDHLQYFKFIGRFIAMALYHGRFIYSGFTMPFYKRMLNKKLTIKDIETIDPEFYNSLIWVKDNN 741
            |||||:|||||||||||||:||:||.:||::|||||:|||.|.:||:|:|||||||||||:||||
Zfish   579 NPDHLKYFKFIGRFIAMALFHGKFIDTGFSLPFYKRILNKPLALKDLESIDPEFYNSLIWIKDNN 643

  Fly   742 IDECGLELWFSVDFEVLGQIIHHELKENGEKERVTEENKEEYITLMTEWRMTRGIEQQTKTFLEG 806
            |:|||||::||||.|:||::..||||.:|...:||||||||||.|:.|||::||:|:||:.||||
Zfish   644 IEECGLEMFFSVDKEILGEVTTHELKPDGGNIQVTEENKEEYIRLVAEWRLSRGVEEQTQAFLEG 708

  Fly   807 FNEVVPLEWLKYFDERELELILCGMQDVDVEDWQRNTIYRHYNRNSKQVVWFWQFVRETDNEKRA 871
            ||:|:|.::|:|||.:|||::|||||::|:.|||||:|||||.|:|||:|||||||:|.|||||.
Zfish   709 FNDVLPQQYLQYFDAKELEVMLCGMQEIDLGDWQRNSIYRHYARSSKQIVWFWQFVKEMDNEKRM 773

  Fly   872 RLLQFVTGTCRVPVGGFAELMGSNGPQRFCIEKVGKETWLPRSHTCFNRLDLPPYKSYDQLVEKL 936
            |||||||||||:||||||:||||||||:|||||||||.||||||||||||||||||||:||.|||
Zfish   774 RLLQFVTGTCRLPVGGFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKL 838

  Fly   937 TFAIEETEGFCQE 949
            .|||||||||.||
Zfish   839 LFAIEETEGFGQE 851

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Su(dx)	NP_476753.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988	43/125 (34%)
		WW	364..396	CDD:197736	20/31 (65%)
		HUL4	<395..946	CDD:227354	369/557 (66%)
itcha	NP_001274024.1	C2_E3_ubiquitin_ligase	2..125	CDD:175988	43/125 (34%)
		WW	276..305	CDD:459800	18/28 (64%)
		HUL4	<307..851	CDD:227354	371/559 (66%)