DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Su(dx) and itchb

DIOPT Version :9

Sequence 1:	NP_001259898.1	Gene:	Su(dx) / 33379	FlyBaseID:	FBgn0003557	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	NP_001289155.1	Gene:	itchb / 100330031	ZFINID:	ZDB-GENE-131024-2	Length:	867	Species:	Danio rerio

Alignment Length:	915	Identity:	478/915 - (52%)
Similarity:	615/915 - (67%)	Gaps:	81/915 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 QLSVTIEEASLRNN--GFLKPNPYVELLIDSKSKRKTDLVKNSYLPKWNEEFTVLITPNSTLHFK 112
            ||.:.:..|.|:.|  .:..|:||||:.:|.:|| ||:...|::.|||.:.|.|::||.|.|.|:
Zfish    19 QLQIMVISAKLKENKKNWFGPSPYVEVCVDGQSK-KTEKCNNTHSPKWKQSFVVIVTPFSKLIFR 82

  Fly   113 VLDHSSFRKDAMLGERIINLAHILQHYNGR-CEFLELTIDLFVTSKSDNRQTKSGELVAILNGLK 176
            |..|.:.:.|.:||...::::..|:.::.: ||.:: |:.|....:||:    .|:|...|:||:
Zfish    83 VWSHQTLKSDLLLGVATLDISETLKSHDMKICEVVQ-TLQLCDRDQSDS----IGDLSVCLDGLQ 142

  Fly   177 LDMSKLQIQPVAGQQNGNPPVQAVNPSVVSDAAAGRSCMIYGGVRARMRLRSSSGNSNGGETRSP 241
            :|....| ...|..||      .:|.....:..:|||             |..|.:.:.|:.|..
Zfish   143 VDPEMFQ-SAEASNQN------TLNGESELNEDSGRS-------------RDPSPSVSEGQDRPA 187

  Fly   242 LPNGGGDHRRSTQAPPVWEQQQQQSQNQQQPLRMVNGSGAAVPQTAPYPQQPPAPALARPLT--- 303
            .|||   ......:|.|    ..:|...|:|               |.|.:||.|...||.:
Zfish   188 APNG---RVNGLDSPSV----SARSSRAQRP---------------PRPSRPPPPTPRRPTSSPA 230

  Fly   304 QVYGALPENTQPA----AVYLPAGGGAAVGPPGVAGPPIEQPGVGLPVSQSTDPQLQTQPADDEP 364
            ...|:.|:.:..:    .|..|.||||:...|   .|.:|||| ...:|....|.......:..|
Zfish   231 SSTGSFPDGSDSSRSDTPVRNPTGGGASDSSP---APTVEQPG-RTALSVGPTPSRIPSMVNAGP 291

  Fly   365 LPAGWEIRLDQYGRRYYVDHNTRSTYWEKPTPLPPGWEIRKDGRGRVYYVDHNTRKTTWQRPNSE 429
            ||.|||.|:||.||.|:|||..:.|.||:|.|||.|||.|.|..||||:|||.||.||||||..|
Zfish   292 LPPGWEQRVDQNGRLYFVDHVEKRTTWERPEPLPSGWERRVDPMGRVYFVDHITRTTTWQRPTME 356

  Fly   430 RLMHFQHWQGQRAHV---VSQGNQRYLYSQQQQQPTAVTAQVTQDDE-DALGPLPDGWEKKIQSD 490
            .:.:::.||.||:.:   :.|.|||::...|.|      |..||:.| |.|||||.||||:..|:
Zfish   357 TVRNYEQWQHQRSQLQGAMQQFNQRFIIGLQDQ------ASATQNKEFDPLGPLPHGWEKRTDSN 415

  Fly   491 NRVYFVNHKNRTTQWEDPRTQGQEVSLINEGPLPPGWEIRYTAAGERFFVDHNTRRTTFEDPRPG 555
            .|||||:|..|:||||||||||    |:||.|||.|||:|:|..|..:|||||.|.||:.|||.|
Zfish   416 GRVYFVHHPTRSTQWEDPRTQG----LLNEKPLPEGWEMRFTVDGIPYFVDHNRRTTTYIDPRTG 476

  Fly   556 APKGAKGVYGVPR-AYERSFRWKLSQFRYLCQSNALPSHIKITVTRQTLFEDSYHQIMRLPAYEL 619
            ......|    |: .|.|.|:.|:..||:.||..::|.||||.|:|:||||||:.|||...|.:|
Zfish   477 KSSLENG----PQITYVRDFKAKVQYFRFWCQQLSMPQHIKINVSRKTLFEDSFQQIMSFSAQDL 537

  Fly   620 RRRLYIIFRGEEGLDYGGVSREWFFLLSHEVLNPMYCLFEYANKNNYSLQINPASYVNPDHLQYF 684
            ||||:|||.||||||||||:||||||||||||||||||||||.|:||.||||||||:|||||:||
Zfish   538 RRRLWIIFPGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYF 602

  Fly   685 KFIGRFIAMALYHGRFIYSGFTMPFYKRMLNKKLTIKDIETIDPEFYNSLIWVKDNNIDECGLEL 749
            |||||||||||:||:||.:||::|||||:|||.||:||:|:|||||||||||:|||||:|||||:
Zfish   603 KFIGRFIAMALFHGKFIDTGFSLPFYKRILNKPLTLKDLESIDPEFYNSLIWIKDNNIEECGLEM 667

  Fly   750 WFSVDFEVLGQIIHHELKENGEKERVTEENKEEYITLMTEWRMTRGIEQQTKTFLEGFNEVVPLE 814
            :||||.|:||::..||||.:|...:||||||||||.|:.|||::||:|:||:.|.||||||:|.:
Zfish   668 FFSVDKEILGEVSTHELKPDGGNIQVTEENKEEYIRLVAEWRLSRGVEEQTQAFFEGFNEVLPQQ 732

  Fly   815 WLKYFDERELELILCGMQDVDVEDWQRNTIYRHYNRNSKQVVWFWQFVRETDNEKRARLLQFVTG 879
            :|:|||.:|||::|||||::|:.|||||||||||..:|||::|||||::|.|||||.||||||||
Zfish   733 YLQYFDAKELEVMLCGMQEIDLNDWQRNTIYRHYTSSSKQIMWFWQFIKEMDNEKRMRLLQFVTG 797

  Fly   880 TCRVPVGGFAELMGSNGPQRFCIEKVGKETWLPRSHTCFNRLDLPPYKSYDQLVEKLTFAIEETE 944
            |||:||||||:||||||||:|||||||||.|||||||||||||||||:||:||.|||.|||||||
Zfish   798 TCRLPVGGFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYRSYEQLKEKLMFAIEETE 862

  Fly   945 GFCQE 949
            ||.||
Zfish   863 GFGQE 867

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(dx)	NP_001259898.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988	40/125 (32%)
		WW	364..396	CDD:197736	19/31 (61%)
		WW	397..426	CDD:278809	20/28 (71%)
		WW	478..509	CDD:197736	20/30 (67%)
		WW	522..554	CDD:197736	19/31 (61%)
		HECTc	594..946	CDD:238033	266/351 (76%)
		HECTc	620..946	CDD:214523	250/325 (77%)
itchb	NP_001289155.1	C2_E3_ubiquitin_ligase	17..139	CDD:175988	40/125 (32%)
		WW	292..321	CDD:278809	17/28 (61%)
		WW	324..353	CDD:278809	20/28 (71%)
		WW	404..433	CDD:278809	18/28 (64%)
		WW	443..474	CDD:197736	18/30 (60%)
		HECTc	512..865	CDD:238033	267/352 (76%)
		HECTc	536..864	CDD:214523	251/327 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	69	1.000	Domainoid score	I9598
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52003
OrthoDB	1	1.010	-	-		D126241at33208
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	1	1.000	-	-		otm25253
orthoMCL	1	0.900	-	-		OOG6_100256
Panther	1	1.100	-	-	O	PTHR11254
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X898
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.930