DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Su(dx) and hecw1

DIOPT Version :9

Sequence 1:	NP_001259898.1	Gene:	Su(dx) / 33379	FlyBaseID:	FBgn0003557	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	XP_017950053.1	Gene:	hecw1 / 100170498	XenbaseID:	XB-GENE-5969056	Length:	1600	Species:	Xenopus tropicalis

Alignment Length:	1175	Identity:	328/1175 - (27%)
Similarity:	464/1175 - (39%)	Gaps:	375/1175 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 QTVNGAGSASP-TPT-----------SSSGAGASGSANQGYHQLSVTIEEAS----------LRN 62
            :||..:....| ||.           |...|..||..:: ..|.||.::|.|          :..
Frog   550 ETVIASACGEPETPRTHYIRIHNLLHSLPSAQMSGDGDE-EEQNSVDLDEESTVKETSEKDIVSE 613

  Fly    63 NGFLKPNPYVELLIDSKSKRKTDLVKNSYLPKWNEEFTVLITPNSTLHFKVLDHSSFRKDAMLGE 127
            ...:.|:|..|::||     :.|.|:||..|        |...:::.|....:|:
Frog   614 TETVAPDPSSEVVID-----ENDDVENSRSP--------LPLDSTSPHLPSCNHN---------- 655

  Fly   128 RIINLAHILQHYNGRCEFLELTIDLFVTSKSDNRQTKSGELVAILNGLKLDMSKLQIQPVAGQQN 192
                           |..:||   |...|:||:                           :.:.:
Frog   656 ---------------CLDVEL---LRTESESDS---------------------------SARVH 675

  Fly   193 GNPPVQAVNPSVVSDAAAGRSC--------MIYGGVRARMRLRSSSGNSNGGETRSPLPNGGGDH 249
            |:......:.|..|.:....||        ..|           .|.|.....||.    ...|.
Frog   676 GDHECDTCDTSCYSTSCYSTSCYSTSCYSPSCY-----------DSHNRFSSHTRF----SSVDS 725

  Fly   250 RRSTQAPPVWEQQQQQSQNQQQPLRMVNGSGAAVPQTAPYPQQPPAPALARPLTQVYGALPENTQ 314
            .|.:::.....|..::.:|             :..::.|...|.|.|  .|..........::|.
Frog   726 ARMSESTVFSSQDDEEDEN-------------SAFESMPDSNQSPEP--ERDQADGSNQWSDDTS 775

  Fly   315 PAAVYLPAGGGAAVGPPGVAGPPIEQPG-VGLPVSQSTDPQLQTQPAD-------DEPLPAGWEI 371
            ..:|......|....|  ||||.....| ..||.:..:..||.:..||       |||||..||.
Frog   776 GQSVNSERTLGVLESP--VAGPSNRTEGDCTLPNTTPSVTQLPSLRADHHHYPTIDEPLPPNWEA 838

  Fly   372 RLDQYGRRYYVDHNTRSTYWEKPT----------------------------------------- 395
            |:|.:||.:||||..|:|.|::||
Frog   839 RIDSHGRVFYVDHVNRTTTWQRPTTAATPDGISRSGSIQQMEQLNRRYQNIQRTIATERTEEDSL 903

  Fly   396 ----------------------------------------------------------------- 395

Frog   904 GRNDRAPGVGDSETDLSQPNTELRREGSLTPINSQKITLLLQSPAVKFITNPEFFTILHANYSAY 968

  Fly   396 --------------------------------------------PLPPGWEIRKDGRGRVYYVDH 416
                                                        .||.||||:.|.:|:.::|||
Frog   969 RVFTNSTCLKHMVLKIRRDARNFERYQHNRDLVNFINMFADTRLELPRGWEIKTDQQGKSFFVDH 1033

  Fly   417 NTRKTTWQRPN--------SERLMHFQHWQGQRAHVVSQGNQ--RYLYSQQQQQP--TAVTAQVT 469
            |:|.||:..|.        ...|.|.||.|..|::...:.::  |...:....:|  :.|||...
Frog  1034 NSRATTFIDPRIPLQNGRLPNHLTHRQHLQRLRSYSAGEASEVSRNRGASLLARPGHSLVTAVRN 1098

  Fly   470 QDDEDALGPLPDGWEKKIQSDNRVYFVNHKN--RTTQWEDP---------------RTQGQE--- 514
            |...:|: ||       ..:|..|.|:...|  ...|...|               ||:|..
Frog  1099 QHQHEAV-PL-------AYNDKIVAFLRQPNIFEMLQERQPSLARNHALREKIHYIRTEGTHGLE 1155

  Fly   515 -----------VSLINEG-----PLPPGWEIRYTAAGERFFVDHNTRRTTFEDPR--PG-APKGA 560
                       :||..|.     ||...:...|:.:                 ||  || :|:.:
Frog  1156 KLSCDADLVILLSLFEEDIMSYIPLQAAFHPGYSFS-----------------PRCSPGSSPQNS 1203

  Fly   561 KGVY----GVPRAYERSFRWKLSQFRYLCQSNAL---PSHIKITVTRQTLFEDSYHQIMRLPAYE 618
            .|:.    ..|..|.|.|..||..|....::...   |..||:.:.|..|.|.:::|:|.....|
Frog  1204 PGLQRASARAPSPYRRDFEAKLRNFYRKLEAKGYGQGPGKIKLIIRRDHLLEGTFNQVMAYSRKE 1268

  Fly   619 LRR-RLYIIFRGEEGLDYGGVSREWFFLLSHEVLNPMYCLFEYANKNNYSLQINPASYVNPDHLQ 682
            |:| :|||.|.|||||||.|.|||:|||||.|:.||.|.||||:..:.|::||:|.|....:||:
Frog  1269 LQRNKLYITFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFVENHLE 1333

  Fly   683 YFKFIGRFIAMALYHGRFIYSGFTMPFYKRMLNKKLTIKDIETIDPEFYNSLIWVKDNNIDECGL 747
            :|:|.||.:.:||.|...:.:.||.||||.:|.....:.|:|.:|.||:.||.|:|||:|.:. |
Frog  1334 WFRFSGRILGLALIHQYLLDAFFTRPFYKALLRLPCDLSDLEYLDEEFHQSLQWMKDNDITDI-L 1397

  Fly   748 ELWFSVDFEVLGQIIHHELKENGEKERVTEENKEEYITLMTEWRMTRGIEQQTKTFLEGFNEVVP 812
            :|.|:|:.||.||:...|||..|...:|:|:||:|||..|.:||:.||:.|||:..:.||.|||.
Frog  1398 DLTFTVNEEVFGQVTERELKSGGANIQVSEKNKKEYIEKMVKWRVERGVVQQTEALVRGFYEVVD 1462

  Fly   813 LEWLKYFDERELELILCGMQDVDVEDWQRNTIYR-HYNRNSKQVVWFWQFVRETDNEKRARLLQF 876
            ...:..||.|||||::.|..::|:.||:.||.|| .|:.....:.|||..|...:||:|.|||||
Frog  1463 SRLVSVFDARELELVIAGTAEIDLNDWRNNTEYRGGYHDGHIVIRWFWAAVERFNNEQRLRLLQF 1527

  Fly   877 VTGTCRVPVGGFAELMGSNGPQRFCIEKVGKETWLPRSHTCFNRLDLPPYKSYDQLVEKLTFAIE 941
            ||||..||..|||.|.||||.:||||||.||.|.|||:||||||||||||.||..|.|||..|:|
Frog  1528 VTGTSSVPYEGFAALRGSNGLRRFCIEKWGKITSLPRAHTCFNRLDLPPYPSYSMLHEKLLIAVE 1592

  Fly   942 ETEGF 946
            ||..|
Frog  1593 ETSTF 1597

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(dx)	NP_001259898.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988	25/134 (19%)
		WW	364..396	CDD:197736	18/181 (10%)
		WW	397..426	CDD:278809	15/28 (54%)
		WW	478..509	CDD:197736	8/47 (17%)
		WW	522..554	CDD:197736	5/33 (15%)
		HECTc	594..946	CDD:238033	179/353 (51%)
		HECTc	620..946	CDD:214523	170/327 (52%)
hecw1	XP_017950053.1	HECW_N	67..186	CDD:374632
		C2_NEDL1-like	207..343	CDD:176073
		MSCRAMM_SdrC	<588..786	CDD:380146	46/296 (16%)
		WW	832..861	CDD:366073	15/28 (54%)
		HECW1_helix	942..1008	CDD:375862	0/65 (0%)
		WW	1014..1045	CDD:197736	16/30 (53%)
		HECTc	1268..1597	CDD:214523	172/329 (52%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000