DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Su(dx) and hecw2a

DIOPT Version :9

Sequence 1:	NP_001259898.1	Gene:	Su(dx) / 33379	FlyBaseID:	FBgn0003557	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	XP_009302976.1	Gene:	hecw2a / 100150269	ZFINID:	ZDB-GENE-090311-22	Length:	1475	Species:	Danio rerio

Alignment Length:	1395	Identity:	366/1395 - (26%)
Similarity:	528/1395 - (37%)	Gaps:	494/1395 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 NGLPAGAASGGMEAG---------------QTVNGAGSASPTP--------TSSSGAGASGSANQ 46
            ||...|.....:|.|               ..|:||..|: ||        .|..|.|....|:.
Zfish   119 NGTQCGQIVWRLEVGPYFLESETRICFKYYHGVSGALRAT-TPCITVKNPRASVDGQGEGQQASD 182

  Fly    47 GYHQL-SVTIEE---ASLRNNGFLKPNPYVELLIDSKSK------------RKTDLVKNSYLPKW 95
            ...:| |.|:.:   ..|:...|..|:||:::.|....:            |::.:..|:..|.|
Zfish   183 SSRKLVSFTLSDIRAVGLKKGMFFNPDPYLKMSIHPGKRSCFPTFSHHGQERRSGITTNTTNPVW 247

  Fly    96 NEE---FTVLITPNSTLHFKVLDHSSFRKDAMLGERIINLAHILQHYNGRCEFLELTIDLFVTSK 157
            :.|   |..|:|....:..|              ::......|::.:.|:   |.:.:.|.:...
Zfish   248 HGEKHTFVALMTDVLVIEVK--------------DKFAKSRPIIKRFLGQ---LNIPVQLLLERH 295

  Fly   158 SDNRQTKSGELVAIL-----NG---LKLDMSKL---QIQPV----AGQQNGNP------------ 195
            |...|:.|..|...|     :|   .|:|::.:   .:.|.    |...||.|
Zfish   296 STGNQSLSFSLCRRLPTDHVSGQMHFKVDVTSMGPDDVSPETILGAAALNGAPGTPSDDEELPHP 360

  Fly   196 -PVQAVNPSVVSDAAAGRS----------CMIYGGV----------------------------- 220
             |:.:..||..:...:.|:          ..||||.
Zfish   361 LPISSAGPSPTASLGSNRNGEGSSIPSPDTEIYGGTLDDEAPSSPDLLQGSFSEQLDAIEAPKGP 425

  Fly   221 ------RARMRLRSSSG-----------NSNGGETRSPLP-------NGGGDHRRSTQAPP---- 257
                  .|..:||||..           :|:..|.||...       ||   ..||.|.||
Zfish   426 GDRPLGAASPKLRSSFPTHTRLSAMLHIDSDEDEDRSAATEATLSTFNG---IPRSYQTPPKAAA 487

  Fly   258 ---VWE---QQQQQSQNQQQPLRMVNGSGAAVPQTAPYPQQPP---AP----------------- 296
               |::   ::..:....:..:..:| :|..||   |.|:..|   ||
Zfish   488 RGAVFDGGIEEPSEEAGLESEVETLN-AGEEVP---PEPEVVPSSVAPEVETASLMERQEEQGRE 548

  Fly   297 ---------ALARP---LTQV-YGALPENTQP----AAVYLPAGGGAAVGPPG------------ 332
                     .|||.   .|:| ..::..:..|    |:.....|..||:.|.|
Zfish   549 VEVEEEEEEGLARSEELATEVDISSMASDCCPGPASASQEAEQGAEAAIDPGGEDLSDDPPTTYE 613

  Fly   333 VAGPPIEQPGVGLPVSQSTDPQLQT---------------------------QPADDEPLPAG-- 368
            ||....|......|..::..|:..|                           |..:||.:|:|
Zfish   614 VAETAEETHLTNEPEREAPKPEPPTNEEEECEDVTEDTMSRRWSLEATAGVSQEDEDELIPSGDG 678

  Fly   369 -------------WEIRLDQYGRRYYVDHNTRS---------TYWEKPTPLPPGWEIRKDGRGRV 411
                         .|:.:.|...    |....|         .|.....||||.||.|.|..||:
Zfish   679 ESVDSETFVTETESELGVPQVNG----DQRVNSLPSVRQDIHRYQRVDEPLPPNWEARIDSHGRI 739

  Fly   412 YYVDHNTRKTTWQRP----------NSERLMHFQHWQGQRAHVVSQGNQRY------LYSQQQQQ 460
            ::|||..|.||||||          .|..::..:           |.|:||      :.|::.::
Zfish   740 FFVDHVNRTTTWQRPTGPPAPQGLTRSSSILQME-----------QLNRRYQSIRRTMTSERSEE 793

  Fly   461 P---------TAVTAQVTQD-----------DEDALGPLPDGWEKKIQSDNRVYFVNHKN----- 500
            |         |.|.||...:           ....|..|......|..|....:.|.|.|
Zfish   794 PRVEDPPADETDVLAQSISEYRRDGIIGQSSSRSRLALLLQSPGAKFLSSPDFFSVLHSNPSAYR 858

  Fly   501 ----------------RTTQ-WEDPRTQGQEVSLIN-----EGPLPPGWEIRYTAAGERFFVDHN 543
                            |..| :|..:.....|:.:|     :..||.|||:::...|:.||||||
Zfish   859 MFTSNTCLKHMISKVRRDAQHFERYQHNRDLVNFLNLFSNKQLELPRGWEMKHDHTGKAFFVDHN 923

  Fly   544 TRRTTFEDPR-----------------------------------PGAP---------------- 557
            .|.|||.|||                                   |..|
Zfish   924 CRATTFIDPRLPLQNSRSSGLLAHRQHLSRQRSHSAGEVGDDSRSPSPPVQGRSSRNSQYQDLVP 988

  Fly   558 ------------------------------------------KGAKGVY---------------- 564
                                                      :||.|:.
Zfish   989 VAYNDKIVAFLRQPNIFEILQERQPELVRNHSLREKVQFIRNEGATGLTRLSSDADLVMLLSLFE 1053

  Fly   565 --------------------------GVPRA-------YERSFRWKLSQFRYLCQSNAL---PSH 593
                                      |.|||       |:|.|..||..|....::...   |..
Zfish  1054 EEVMSYVPPNALLLSSYCHASPQSSPGTPRANARAPAPYKRDFEAKLRNFYRKMETKGYGQGPGK 1118

  Fly   594 IKITVTRQTLFEDSYHQIMRLPAYELRR-RLYIIFRGEEGLDYGGVSREWFFLLSHEVLNPMYCL 657
            :|:.:.|..|.||:::|||.....:|:| |||:.|.|||||||.|.|||:|||:|.|:.||.|.|
Zfish  1119 VKLIIRRDHLLEDAFNQIMCYSRKDLQRSRLYVSFVGEEGLDYSGPSREFFFLVSRELFNPYYGL 1183

  Fly   658 FEYANKNNYSLQINPASYVNPDHLQYFKFIGRFIAMALYHGRFIYSGFTMPFYKRMLNKKLTIKD 722
            |||:..:.|::||:|.|....:|.::|:|.||.:.:||.|...:.:.||.||||.:|.....:.|
Zfish  1184 FEYSANDTYTVQISPMSAFVDNHHEWFRFSGRILGLALIHQYLLDAFFTRPFYKGLLRIPCDLSD 1248

  Fly   723 IETIDPEFYNSLIWVKDNNIDECGLELWFSVDFEVLGQIIHHELKENGEKERVTEENKEEYITLM 787
            :|.:|.||:.||.|:|||:|::. |:|.|:|:.||.|||...|||..|....|:::||:|||..|
Zfish  1249 LEFLDEEFHQSLQWMKDNDIEDM-LDLTFTVNEEVFGQITERELKPGGSGIAVSDKNKKEYIERM 1312

  Fly   788 TEWRMTRGIEQQTKTFLEGFNEVVPLEWLKYFDERELELILCGMQDVDVEDWQRNTIYR-HYNRN 851
            .:||:.||:.|||::.:.||.|||.:..:..||.|||||::.|..::|:.||:.||.|| .|:.|
Zfish  1313 VKWRIERGVAQQTESLVRGFYEVVDVRLVSVFDARELELVIAGTAEIDLSDWRNNTEYRGGYHDN 1377

  Fly   852 SKQVVWFWQFVRETDNEKRARLLQFVTGTCRVPVGGFAELMGSNGPQRFCIEKVGKETWLPRSHT 916
            ...:.|||..|...:||:|.|||||||||..:|..|||.|.|||||:|||:||.||.|.|||:||
Zfish  1378 HIVIRWFWAAVERFNNEQRLRLLQFVTGTSSIPYEGFASLRGSNGPRRFCVEKWGKVTSLPRAHT 1442

  Fly   917 CFNRLDLPPYKSYDQLVEKLTFAIEETEGF 946
            ||||||||||.|:..|.||:..|:|||..|
Zfish  1443 CFNRLDLPPYPSFSMLYEKMVTAVEETSTF 1472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(dx)	NP_001259898.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988	27/148 (18%)
		WW	364..396	CDD:197736	7/55 (13%)
		WW	397..426	CDD:278809	17/28 (61%)
		WW	478..509	CDD:197736	9/52 (17%)
		WW	522..554	CDD:197736	19/66 (29%)
		HECTc	594..946	CDD:238033	175/353 (50%)
		HECTc	620..946	CDD:214523	166/327 (51%)
hecw2a	XP_009302976.1	HECW_N	50..169	CDD:318711	11/50 (22%)
		C2_NEDL1-like	188..323	CDD:176073	27/151 (18%)
		WW	724..756	CDD:197736	20/31 (65%)
		WW	903..934	CDD:197736	18/30 (60%)
		HECTc	1120..1473	CDD:238033	176/354 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.810