DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Su(dx) and wwp1

DIOPT Version :9

Sequence 1:	NP_001259898.1	Gene:	Su(dx) / 33379	FlyBaseID:	FBgn0003557	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	NP_001090844.1	Gene:	wwp1 / 100038255	XenbaseID:	XB-GENE-992697	Length:	914	Species:	Xenopus tropicalis

Alignment Length:	968	Identity:	523/968 - (54%)
Similarity:	643/968 - (66%)	Gaps:	101/968 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 SASPTPTSSSGAGASGSANQGYH-QLSVTIEEASL-RNNGFLKPNPYVELLIDSKSKRKTDLVKN 89
            :|||.|         |:.|.... ||.||:..|.| |...:.....|.||.:|.::| ||....:
Frog     3 TASPRP---------GNRNSLEDLQLHVTVSCAKLKRKKNWFGTTVYTELAVDGETK-KTAKSSS 57

  Fly    90 SYLPKWNEEFTVLITPNSTLHFKVLDHSSFRKDAMLGERIINLAHILQHYNGRCEFLELTIDLFV 154
            |..|||.|..||.:||.:||.|||..|.|::.||:||:..::|...|:.:|.:.|.::..:.|.:
Frog    58 SSNPKWEERLTVSVTPQTTLEFKVWSHHSWKADALLGKTAVDLKQALETHNRKLERVKEQLKLSL 122

  Fly   155 TSKSDNRQTKSGELVAILNGLKLDMSKL-----------QIQPVAGQQNGNPPVQAVNPSVVSDA 208
            ..|....||  |||..||:||.::...|           :|     ||||: .|:........:|
Frog   123 DGKHGTVQT--GELTVILDGLNVEPESLATFNSTATPAREI-----QQNGD-AVRENGGETSLEA 179

  Fly   209 AAGRSCMIYGGVRARMRLRSSSGN---SNGGETRSPLPNGGGDHRRSTQAPPVWEQQQQQSQNQQ 270
            ..|.:|.:..|..:......::.|   :|...|.|  |:......::|.||
Frog   180 RVGATCDMPNGTASETTSEQNAFNTQIANIDSTHS--PSRVAARPKNTPAP-------------- 228

  Fly   271 QPL---RMVNGSGA-AVPQTAPYPQQPPAPALARPLTQVYGALPENTQPAAVYLPAGGGAAV--- 328
            .||   |.|||:.| :...:.|..:..|:||.|.....:  .:.::|....|.:|...|.:.
Frog   229 NPLTGDRTVNGTSATSEANSTPSHEALPSPAGAPSSDSI--EMMDSTSDGPVSIPLDSGTSAESS 291

  Fly   329 --------------GPPGVAGPPIEQPGVGLPVSQST----DPQLQTQPADDEPLPAGWEIRLDQ 375
                          ||...||.  ..|....|...|:    ||..|...:..||||:|||.|.|.
Frog   292 SAGASSEPVRAADSGPSPAAGS--NSPDAAKPRQASSTGSGDPVRQQPSSAAEPLPSGWEQRKDP 354

  Fly   376 YGRRYYVDHNTRSTYWEKPTPLPPGWEIRKDGRGRVYYVDHNTRKTTWQRPNSERLMHFQHWQGQ 440
            :||.||||||||:|.||:|.|||||||.|.|.||||||||||||.||||||..|.:.:|:.||.|
Frog   355 HGRTYYVDHNTRTTTWERPQPLPPGWERRVDDRGRVYYVDHNTRTTTWQRPTMESVRNFEQWQSQ 419

  Fly   441 RAHV---VSQGNQRYLYSQQQQQPTAVTAQVTQDDEDALGPLPDGWEKKIQSDNRVYFVNHKNRT 502
            |..:   :.|.|||||||          |.:...:.|.|||||.|||:::.|.:|||||||..:|
Frog   420 RNQLQGAMQQFNQRYLYS----------ASMLSAENDPLGPLPPGWERRVDSTDRVYFVNHNTKT 474

  Fly   503 TQWEDPRTQGQEVSLINEGPLPPGWEIRYTAAGERFFVDHNTRRTTFEDPRPGAPKGAKGVYGVP 567
            ||||||||||    |.||.|||.|||||||..|.::||||||:.|||.|||.|....:||    |
Frog   475 TQWEDPRTQG----LQNEDPLPEGWEIRYTREGVKYFVDHNTKTTTFSDPRTGKSAVSKG----P 531

  Fly   568 R-AYERSFRWKLSQFRYLCQSNALPSHIKITVTRQTLFEDSYHQIMRLPAYELRRRLYIIFRGEE 631
            : ||||||||||:.|||||||||||||:||||:||||||||:.|||.|..|:||||||::|||||
Frog   532 QIAYERSFRWKLAHFRYLCQSNALPSHVKITVSRQTLFEDSFQQIMALKPYDLRRRLYVMFRGEE 596

  Fly   632 GLDYGGVSREWFFLLSHEVLNPMYCLFEYANKNNYSLQINPASYVNPDHLQYFKFIGRFIAMALY 696
            ||||||::||||||||||||||||||||||.|:||.|||||||.:|||||.||.||||||||||:
Frog   597 GLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKSNYCLQINPASTINPDHLSYFCFIGRFIAMALF 661

  Fly   697 HGRFIYSGFTMPFYKRMLNKKLTIKDIETIDPEFYNSLIWVKDNNIDECGLELWFSVDFEVLGQI 761
            ||:||.:||::|||||||:|||||||:|:|||||||||||::||||:||.||::||||.|:||::
Frog   662 HGKFIDTGFSLPFYKRMLSKKLTIKDLESIDPEFYNSLIWIRDNNIEECNLEMYFSVDMEILGKV 726

  Fly   762 IHHELKENGEKERVTEENKEEYITLMTEWRMTRGIEQQTKTFLEGFNEVVPLEWLKYFDERELEL 826
            ..|:||..|....||||||||||.||.|||.:||:|:|||.||:|||.||||:||:||||:|||:
Frog   727 TSHDLKPEGSNILVTEENKEEYIGLMAEWRFSRGVEEQTKAFLDGFNAVVPLQWLQYFDEKELEV 791

  Fly   827 ILCGMQDVDVEDWQRNTIYRHYNRNSKQVVWFWQFVRETDNEKRARLLQFVTGTCRVPVGGFAEL 891
            :|||||:||:.||||||:||||.|||||::||||||:|.|||.|.|||||||||||:|:||||||
Frog   792 MLCGMQEVDLSDWQRNTVYRHYTRNSKQIIWFWQFVKEMDNEVRLRLLQFVTGTCRLPLGGFAEL 856

  Fly   892 MGSNGPQRFCIEKVGKETWLPRSHTCFNRLDLPPYKSYDQLVEKLTFAIEETEGFCQE 949
            |||||||:||||||||||||||||||||||||||||||:||.|||.|||||||||.||
Frog   857 MGSNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQE 914

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(dx)	NP_001259898.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988	46/126 (37%)
		WW	364..396	CDD:197736	22/31 (71%)
		WW	397..426	CDD:278809	24/28 (86%)
		WW	478..509	CDD:197736	20/30 (67%)
		WW	522..554	CDD:197736	22/31 (71%)
		HECTc	594..946	CDD:238033	273/351 (78%)
		HECTc	620..946	CDD:214523	255/325 (78%)
wwp1	NP_001090844.1	C2_E3_ubiquitin_ligase	18..139	CDD:175988	46/123 (37%)
		motB	<168..346	CDD:183756	42/197 (21%)
		HUL4	<313..914	CDD:227354	427/620 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	526	1.000	Domainoid score	I297
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H21385
Inparanoid	1	1.050	982	1.000	Inparanoid score	I312
OMA	1	1.010	-	-		QHG52003
OrthoDB	1	1.010	-	-		D126241at33208
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	1	1.000	-	-		otm49175
Panther	1	1.100	-	-	LDO	PTHR11254
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X898
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.080