Protein Alignment Su(dx) and smurf2

DIOPT Version :10

• Sequence 1: NP_476753.1
• Gene: Su(dx) / 33379
• FlyBaseID: FBgn0003557
• Length: 949
• Species: Drosophila melanogaster
• Sequence 2: XP_031750530.1
• Gene: smurf2 / 100038194
• XenbaseID: XB-GENE-481391
• Length: 752
• Species: Xenopus tropicalis
• Alignment Length: 949
• Identity: 316/949 - (33%)
• Similarity: 443/949 - (46%)
• Gaps: 242/949 - (25%)

  Fly    42 GSANQGYHQLSVTIEEA-SLRNNGFLK--PNPYVELLIDSKSK-RKTDLVKNSYLPKWNEEFTVL 102
            ||...|..:|.:|:..| :|....|..  |:|:.::::|...: ..||.|||:..||||:.:.:.
 Frog     5 GSRRNGPVKLRLTVLCAKNLVKKDFFTGLPDPFAKVVVDGSGQCHSTDTVKNTLDPKWNQHYDLY 69

  Fly   103 ITPNSTLHFKVLDHSSFRKDAMLGERIINLAHILQHYNGRCEFLELTIDLFVTSKSDNRQTKSGE 167
            |..:.::...|.:|....|..  |...:....:|                   |.:.||...:|.
 Frog    70 IGKSDSITISVWNHKKIHKKQ--GAGFLGCVRLL-------------------SNAINRLKDTGY 113

  Fly   168 LVAILNGLKLDMSKLQIQPVAGQQNGNPPVQAVNPSVVSDAAAGRSCMIYGGVRARMRLRSSSGN 232
                   .:||:.||       ..|.|..|:.               .|...:::|.|:
 Frog   114 -------QRLDLCKL-------GPNDNDTVRG---------------QIVVSLQSRDRI------ 143

  Fly   233 SNGGETRSPLPNGGGDHRRSTQAPPVWEQQQQQSQNQQQPLRMVNGSGAAVPQTAPYPQQPPAPA 297
                                                         |||..|
 Frog   144 ---------------------------------------------GSGGQV-------------- 149

  Fly   298 LARPLTQVYGALPENTQPAAVYLPAGGGAAVGPPGVAGPPIEQPGVGLPVSQSTDPQLQTQPADD 362
                                                                     :......|
 Frog   150 ---------------------------------------------------------VDCSRLFD 157

  Fly   363 EPLPAGWEIRLDQYGRRYYVDHNTRSTYWEKPTPLPPGWEIRKDGRGRVYYVDHNTRKT-----T 422
            ..||.|||.|....||..|::|.||:|.||:||  .|..|....||....:||.||..|     |
 Frog   158 NDLPDGWEERRTASGRIQYLNHITRTTQWERPT--RPASEYSSPGRPLSCFVDENTPITGTNGAT 220

  Fly   423 WQRPNSERLMHFQHWQGQRAHVVSQGNQRYLYSQQQQQPTAVTAQVTQDDEDALGPLPDGWEKKI 487
            ..:.:..|:        ....|.||.::.|:.......|.               .||:|:|::.
 Frog   221 CGQTSDPRI--------AERRVRSQRHRNYMSRTHLHTPP---------------DLPEGYEQRT 262

  Fly   488 QSDNRVYFVNHKNRTTQWEDPRTQGQEVSLIN---EGPLPPGWEIRYTAAGERFFVDHNTRRTTF 549
            ....:|||::.:...:.|.|||.. :::|.||   .||||||||||.||.|..:|||||.|.|.|
 Frog   263 TQQGQVYFLHTQTGVSTWHDPRVP-RDLSNINCEELGPLPPGWEIRNTATGRVYFVDHNNRTTQF 326

  Fly   550 EDPRPGA---------------------------PKGAKGVYGVPRAYERSFRWKLSQFRY-LCQ 586
            .|||..|                           |...: ...||| |:|....||...|. |.|
 Frog   327 TDPRLSANLHLVLNRQNQQLKEQQPPQVVPLCQLPDEVE-CLTVPR-YKRDLVHKLKILRQELSQ 389

  Fly   587 SNALPSHIKITVTRQTLFEDSYHQIMRLPAYELRRRLYIIFRGEEGLDYGGVSREWFFLLSHEVL 651
            ......|.:|.|:|:.:||:||.|:|::...:|.:||.|.||||||||||||:|||.:|||||:|
 Frog   390 QQPQAGHCRIEVSREEIFEESYRQVMKMRPKDLWKRLMIKFRGEEGLDYGGVAREWLYLLSHEML 454

  Fly   652 NPMYCLFEYANKNNYSLQINPASYVNPDHLQYFKFIGRFIAMALYHGRFIYSGFTMPFYKRMLNK 716
            ||.|.||:|:..:.|:|||||.|.|||:||.||.|:||.:.||::||.:|..|||:||||::|.|
 Frog   455 NPYYGLFQYSRDDIYTLQINPDSAVNPEHLSYFHFVGRIMGMAVFHGHYIDGGFTLPFYKQLLGK 519

  Fly   717 KLTIKDIETIDPEFYNSLIWVKDNNIDECGLELWFSVDFEVLGQIIHHELKENGEKERVTEENKE 781
            .:|:.|:|::||:.:|||:|:.:|:|... |:..|.|:....|::|.||||.:|:...||||.|:
 Frog   520 PITLDDMESVDPDLHNSLVWILENDITGV-LDHTFCVEHSAYGELIQHELKPSGKSIPVTEETKK 583

  Fly   782 EYITLMTEWRMTRGIEQQTKTFLEGFNEVVPLEWLKYFDERELELILCGMQDVDVEDWQRNTIYR 846
            ||:.|...||..||||.|.....:|||||:|...||.|||:|||||:||:..:||.||:.||..:
 Frog   584 EYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQHLLKAFDEKELELIICGLGKIDVNDWKSNTRLK 648

  Fly   847 HYNRNSKQVVWFWQFVRETDNEKRARLLQFVTGTCRVPVGGFAELMGSNGPQRFCIEKVGKET-W 910
            |...:|..|.|||:.|...|.|:||||||||||:.|||:.||..|.|:.||:.|.|.::...| .
 Frog   649 HCTADSNIVKWFWKAVESFDEERRARLLQFVTGSSRVPLQGFKALQGAAGPRLFTIHQIDASTNN 713

  Fly   911 LPRSHTCFNRLDLPPYKSYDQLVEKLTFAIEETEGFCQE 949
            ||::||||||:|:|||::|::|.|||..|||||.||..|
 Frog   714 LPKAHTCFNRIDIPPYETYEKLYEKLLTAIEETCGFAVE 752

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Su(dx)	NP_476753.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988	27/128 (21%)
		WW	364..396	CDD:197736	16/31 (52%)
		HUL4	<395..946	CDD:227354	252/587 (43%)
smurf2	XP_031750530.1	C2_Smurf-like	13..138	CDD:176028	35/174 (20%)
		PRP40	156..>237	CDD:227435	30/90 (33%)
		WW	160..189	CDD:459800	15/28 (54%)
		WW	253..284	CDD:197736	9/30 (30%)
		WW	299..331	CDD:197736	22/31 (71%)
		HECTc	397..749	CDD:238033	184/352 (52%)