DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Su(dx) and smurf2

DIOPT Version :9

Sequence 1:	NP_001259898.1	Gene:	Su(dx) / 33379	FlyBaseID:	FBgn0003557	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	XP_031750530.1	Gene:	smurf2 / 100038194	XenbaseID:	XB-GENE-481391	Length:	752	Species:	Xenopus tropicalis

Alignment Length:	949	Identity:	316/949 - (33%)
Similarity:	443/949 - (46%)	Gaps:	242/949 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 GSANQGYHQLSVTIEEA-SLRNNGFLK--PNPYVELLIDSKSK-RKTDLVKNSYLPKWNEEFTVL 102
            ||...|..:|.:|:..| :|....|..  |:|:.::::|...: ..||.|||:..||||:.:.:.
Frog     5 GSRRNGPVKLRLTVLCAKNLVKKDFFTGLPDPFAKVVVDGSGQCHSTDTVKNTLDPKWNQHYDLY 69

  Fly   103 ITPNSTLHFKVLDHSSFRKDAMLGERIINLAHILQHYNGRCEFLELTIDLFVTSKSDNRQTKSGE 167
            |..:.::...|.:|....|..  |...:....:|                   |.:.||...:|.
Frog    70 IGKSDSITISVWNHKKIHKKQ--GAGFLGCVRLL-------------------SNAINRLKDTGY 113

  Fly   168 LVAILNGLKLDMSKLQIQPVAGQQNGNPPVQAVNPSVVSDAAAGRSCMIYGGVRARMRLRSSSGN 232
                   .:||:.||       ..|.|..|:.               .|...:::|.|:
Frog   114 -------QRLDLCKL-------GPNDNDTVRG---------------QIVVSLQSRDRI------ 143

  Fly   233 SNGGETRSPLPNGGGDHRRSTQAPPVWEQQQQQSQNQQQPLRMVNGSGAAVPQTAPYPQQPPAPA 297
                                                         |||..|
Frog   144 ---------------------------------------------GSGGQV-------------- 149

  Fly   298 LARPLTQVYGALPENTQPAAVYLPAGGGAAVGPPGVAGPPIEQPGVGLPVSQSTDPQLQTQPADD 362
                                                                     :......|
Frog   150 ---------------------------------------------------------VDCSRLFD 157

  Fly   363 EPLPAGWEIRLDQYGRRYYVDHNTRSTYWEKPTPLPPGWEIRKDGRGRVYYVDHNTRKT-----T 422
            ..||.|||.|....||..|::|.||:|.||:||  .|..|....||....:||.||..|     |
Frog   158 NDLPDGWEERRTASGRIQYLNHITRTTQWERPT--RPASEYSSPGRPLSCFVDENTPITGTNGAT 220

  Fly   423 WQRPNSERLMHFQHWQGQRAHVVSQGNQRYLYSQQQQQPTAVTAQVTQDDEDALGPLPDGWEKKI 487
            ..:.:..|:        ....|.||.::.|:.......|.               .||:|:|::.
Frog   221 CGQTSDPRI--------AERRVRSQRHRNYMSRTHLHTPP---------------DLPEGYEQRT 262

  Fly   488 QSDNRVYFVNHKNRTTQWEDPRTQGQEVSLIN---EGPLPPGWEIRYTAAGERFFVDHNTRRTTF 549
            ....:|||::.:...:.|.|||.. :::|.||   .||||||||||.||.|..:|||||.|.|.|
Frog   263 TQQGQVYFLHTQTGVSTWHDPRVP-RDLSNINCEELGPLPPGWEIRNTATGRVYFVDHNNRTTQF 326

  Fly   550 EDPRPGA---------------------------PKGAKGVYGVPRAYERSFRWKLSQFRY-LCQ 586
            .|||..|                           |...: ...||| |:|....||...|. |.|
Frog   327 TDPRLSANLHLVLNRQNQQLKEQQPPQVVPLCQLPDEVE-CLTVPR-YKRDLVHKLKILRQELSQ 389

  Fly   587 SNALPSHIKITVTRQTLFEDSYHQIMRLPAYELRRRLYIIFRGEEGLDYGGVSREWFFLLSHEVL 651
            ......|.:|.|:|:.:||:||.|:|::...:|.:||.|.||||||||||||:|||.:|||||:|
Frog   390 QQPQAGHCRIEVSREEIFEESYRQVMKMRPKDLWKRLMIKFRGEEGLDYGGVAREWLYLLSHEML 454

  Fly   652 NPMYCLFEYANKNNYSLQINPASYVNPDHLQYFKFIGRFIAMALYHGRFIYSGFTMPFYKRMLNK 716
            ||.|.||:|:..:.|:|||||.|.|||:||.||.|:||.:.||::||.:|..|||:||||::|.|
Frog   455 NPYYGLFQYSRDDIYTLQINPDSAVNPEHLSYFHFVGRIMGMAVFHGHYIDGGFTLPFYKQLLGK 519

  Fly   717 KLTIKDIETIDPEFYNSLIWVKDNNIDECGLELWFSVDFEVLGQIIHHELKENGEKERVTEENKE 781
            .:|:.|:|::||:.:|||:|:.:|:|... |:..|.|:....|::|.||||.:|:...||||.|:
Frog   520 PITLDDMESVDPDLHNSLVWILENDITGV-LDHTFCVEHSAYGELIQHELKPSGKSIPVTEETKK 583

  Fly   782 EYITLMTEWRMTRGIEQQTKTFLEGFNEVVPLEWLKYFDERELELILCGMQDVDVEDWQRNTIYR 846
            ||:.|...||..||||.|.....:|||||:|...||.|||:|||||:||:..:||.||:.||..:
Frog   584 EYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQHLLKAFDEKELELIICGLGKIDVNDWKSNTRLK 648

  Fly   847 HYNRNSKQVVWFWQFVRETDNEKRARLLQFVTGTCRVPVGGFAELMGSNGPQRFCIEKVGKET-W 910
            |...:|..|.|||:.|...|.|:||||||||||:.|||:.||..|.|:.||:.|.|.::...| .
Frog   649 HCTADSNIVKWFWKAVESFDEERRARLLQFVTGSSRVPLQGFKALQGAAGPRLFTIHQIDASTNN 713

  Fly   911 LPRSHTCFNRLDLPPYKSYDQLVEKLTFAIEETEGFCQE 949
            ||::||||||:|:|||::|::|.|||..|||||.||..|
Frog   714 LPKAHTCFNRIDIPPYETYEKLYEKLLTAIEETCGFAVE 752

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(dx)	NP_001259898.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988	27/128 (21%)
		WW	364..396	CDD:197736	16/31 (52%)
		WW	397..426	CDD:278809	10/33 (30%)
		WW	478..509	CDD:197736	9/30 (30%)
		WW	522..554	CDD:197736	22/31 (71%)
		HECTc	594..946	CDD:238033	184/352 (52%)
		HECTc	620..946	CDD:214523	174/326 (53%)
smurf2	XP_031750530.1	C2_Smurf-like	13..138	CDD:176028	35/174 (20%)
		PRP40	156..>237	CDD:227435	30/90 (33%)
		WW	160..189	CDD:395320	15/28 (54%)
		WW	253..284	CDD:197736	9/30 (30%)
		WW	299..331	CDD:197736	22/31 (71%)
		HECTc	397..749	CDD:238033	184/352 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D167687at2759
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2273
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.040