DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Su(dx) and plekha7b

DIOPT Version :9

Sequence 1:	NP_001259898.1	Gene:	Su(dx) / 33379	FlyBaseID:	FBgn0003557	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	XP_021327578.1	Gene:	plekha7b / 100005106	ZFINID:	ZDB-GENE-091014-2	Length:	1359	Species:	Danio rerio

Alignment Length:	364	Identity:	91/364 - (25%)
Similarity:	125/364 - (34%)	Gaps:	117/364 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   479 LPDGWEKKIQSDNRVYFVNHKNRTTQWEDPRTQGQEVSLINEG-----PLPPGWEIRYTAAGERF 538
            |||.|...:..|.||:|:|.|.|.|.|..||| |:.|   |.|     .||.|||..:|..|..:
Zfish    10 LPDHWSYGVCRDGRVFFINDKTRDTTWLHPRT-GEPV---NSGHMIRSDLPRGWEEGFTEEGASY 70

  Fly   539 FVDHNTRRTTFEDPRPGAPKGAKGVYGV------------PRAYERSFRWKLSQFRYLCQS---- 587
            |::||.|.|||..|..|........:.:            |.|...|.   :|:......|
Zfish    71 FINHNQRSTTFRHPVTGHISSENTDFILQDQANLRMSKPPPEARPPSM---VSESSVAISSSPAD 132

  Fly   588 ------NALPSHIKITVTRQTLFEDSYHQIMRLPAYELRRRLYIIFRGEEGLDYGGVSREWFFLL 646
                  |..||      .:...|....|.|.|.|...:..|.::..:...|:...  .|:||.|.
Zfish   133 ATSGSRNLKPS------GKVHCFGKRDHSIKRNPNVPVVVRGWLYKQDSSGMRLW--KRKWFVLS 189

  Fly   647 SHEVLNPMYCLFEYANKNNYSL--QINPASYV-NP----DHLQYFKFIGRFIAMALYHGRFIYSG 704
            .       ||||.|.:....::  .|...||| :|    ||      |.|..|....|     :|
Zfish   190 D-------YCLFYYKDSREETVLGSIPLPSYVISPVGPEDH------ISRKYAFKACH-----TG 236

  Fly   705 FTMPFYKRMLNKKLTIKDIETIDPEFYNSLIWVKDNNIDECGLELW-FSVDFEVLGQIIHHELKE 768
            .....|.:                   ||||   .:..:.||:..: ||.|
Zfish   237 MRSYIYNK-------------------NSLI---GSQAEHCGMRTYFFSAD-------------- 265

  Fly   769 NGEKERVTEENKEEYI------TLMTEWRMTRGIEQQTK 801
                   |:|:...:|      .||....|.|..|:.:|
Zfish   266 -------TQEDMNGWIRAMNQAALMQSHGMKREAERSSK 297

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(dx)	NP_001259898.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988
		WW	364..396	CDD:197736
		WW	397..426	CDD:278809
		WW	478..509	CDD:197736	13/29 (45%)
		WW	522..554	CDD:197736	15/31 (48%)
		HECTc	594..946	CDD:238033	47/222 (21%)
		HECTc	620..946	CDD:214523	42/196 (21%)
plekha7b	XP_021327578.1	WW	10..39	CDD:306827	13/28 (46%)
		WW	55..84	CDD:306827	14/28 (50%)
		PH_PEPP1_2_3	158..281	CDD:270068	38/185 (21%)
		SMC_N	645..>882	CDD:330553
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000