Protein Alignment CG4238 and AREL1

DIOPT Version :10

• Sequence 1: NP_608640.2
• Gene: CG4238 / 33377
• FlyBaseID: FBgn0031384
• Length: 977
• Species: Drosophila melanogaster
• Sequence 2: NP_001034568.1
• Gene: AREL1 / 9870
• HGNCID: 20363
• Length: 823
• Species: Homo sapiens
• Alignment Length: 843
• Identity: 406/843 - (48%)
• Similarity: 525/843 - (62%)
• Gaps: 87/843 - (10%)

  Fly   197 GMLVVSV-----SVAGLVTLAAMTQPSLAPEAR-----HSLLQYVTGKYLLPANCKVQWDWKDPA 251
            |.:.|||     ::..|..|||.....|..|.|     .::..||.|.||.|.:|||.||||||.
Human     6 GGITVSVVAFFFTIKFLFELAARVVSFLQNEDRERRGDRTIYDYVRGNYLDPRSCKVSWDWKDPY 70

  Fly   252 SVGGTMCFVVRFFQRNGQPYPICDTDHFFVEVTEGTRKVVTISELGSS--------TDPNNANIA 308
            .||.:|.|.|..|.:||||:|.    |..|    |.|..::..||...        .:| |:|:.
Human    71 EVGHSMAFRVHLFYKNGQPFPA----HRPV----GLRVHISHVELAVEIPVTQEVLQEP-NSNVV 126

  Fly   309 KVKFTVRTAGQYKISVLIGASHIAGSPFLRSFLPGAIDARRSRFIRPASTVICCAGAPTLMHIEP 373
            ||.||||.||:|:|:|.:|..::|.||:.:.|.||.:...:::.:...||::...|.|..:.|.|
Human   127 KVAFTVRKAGRYEITVKLGGLNVAYSPYYKIFQPGMVVPSKTKIVCHFSTLVLTCGQPHTLQIVP 191

  Fly   374 RDEFGNSCLFDQNQSDEALQGYQVAIYDLHGVPVEKLQHAIVFAYDKVNSR----VSVTALFPEP 434
            |||:.|......:..||  ..|.::|::|.  |.|:....:.|.....::|    |.:.......
Human   192 RDEYDNPTNNSMSLRDE--HNYTLSIHELG--PQEEESTGVSFEKSVTSNRQTFQVFLRLTLHSR 252

  Fly   435 TCLRAVISYRDQQLPNGDFDIIVLSSSDTTLVHKNIASRKHNICYEAKLLSIFGVSK-------- 491
            .|..|.|||::|.:.||:|||||||..:..:|.:|:::...:|.:||.|.:....|.
Human   253 GCFHACISYQNQPINNGEFDIIVLSEDEKNIVERNVSTSGVSIYFEAYLYNATNCSSTPWHLPPM 317

  Fly   492 ------------------------------NKPRKVLCYVGPKQNSLIFQVTIKEMILKFIPKRI 526
                                          .||:||.|||.|||.|      :||..||.||.|:
Human   318 HMTSSQRRPSTAVDEEDEDSPSECHTPEKVKKPKKVYCYVSPKQFS------VKEFYLKIIPWRL 376

  Fly   527 ATFRLCPSTKFHFL-PQLVSQLHGPVFIIDDGAQPKIELASKDRNIIAATFTHFLLKNIGGSETF 590
            .|||:||.|||.:| |..|.:|  ...::|||.||.:||:.|:|||:||||...|.|||||||||
Human   377 YTFRVCPGTKFSYLGPDPVHKL--LTLVVDDGIQPPVELSCKERNILAATFIRSLHKNIGGSETF 439

  Fly   591 KDKQDFFYHEVRKFHASYYHEKMALKVQREKILESSMKAVKGFSVSDWCGNFEVTFQGEQGIDWG 655
            :||.:||..|:|:.|....|.|:.|||.|..:||||:||.:.||:|||..||||.||.|:.:|||
Human   440 QDKVNFFQRELRQVHMKRPHSKVTLKVSRHALLESSLKATRNFSISDWSKNFEVVFQDEEALDWG 504

  Fly   656 GLRREWFELVCSALFDARGGLFCTFHDKHQALVHPNPTRPAHLKLKHFEFAGKMVGKCLFESALG 720
            |.|||||||:|.||||....||..|.|.:||||||||.|||||:||.:||||::|||||:||:||
Human   505 GPRREWFELICKALFDTTNQLFTRFSDNNQALVHPNPNRPAHLRLKMYEFAGRLVGKCLYESSLG 569

  Fly   721 GTYRQLVRARFSRSFLAQLIGLRVHYKYFEQDDPDLYLSKIKYILDTDLDATDTLELYFVEEMYD 785
            |.|:|||||||:||||||:||||:||||||.|||:.|.||:.:||:.|:   ..:||.|.||.|
Human   570 GAYKQLVRARFTRSFLAQIIGLRMHYKYFETDDPEFYKSKVCFILNNDM---SEMELVFAEEKY- 630

  Fly   786 SSSGQLSKTIELIPNGAKTRVTNATKNQYLDALAQQRLCNNVKDEVDSFLKGLNSIIPDNLLSIF 850
            :.||||.|.:||:..||:|.||||.|..||:.|||.||.:.||:||:.||||||.::|:|||:||
Human   631 NKSGQLDKVVELMTGGAQTPVTNANKIFYLNLLAQYRLASQVKEEVEHFLKGLNELVPENLLAIF 695

  Fly   851 DENELELLMCGTGEYSISDFKAHHIANGNSAEFR-RVLAWFWAGVSNFSQTEMARLLQFTTGCSQ 914
            |||||||||||||:.|:||||||.:..|.|..|| :|:.|||..||:.:|.|:|||||||||.||
Human   696 DENELELLMCGTGDISVSDFKAHAVVVGGSWHFREKVMRWFWTVVSSLTQEELARLLQFTTGSSQ 760

  Fly   915 LPPGGFQELNPQFQITAAPTFGNLPTAHTCFNQLCLPDYESYEQFEKSLLLAISEGSEGFGMV 977
            ||||||..|.|.|||.||||...||||||||||||||.|:|||:..:.|.||||||.|||||:
Human   761 LPPGGFAALCPSFQIIAAPTHSTLPTAHTCFNQLCLPTYDSYEEVHRMLQLAISEGCEGFGML 823

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4238	NP_608640.2	Filamin	238..336	CDD:395505	44/105 (42%)
		HECTc	615..975	CDD:238033	233/360 (65%)
AREL1	NP_001034568.1	Filamin	52..158		48/114 (42%)
		Filamin	56..154	CDD:395505	44/106 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	315..345		0/29 (0%)
		Interaction with SOCS2. /evidence=ECO:0000269|PubMed:31578312	483..789		199/309 (64%)
		HECTc	486..820	CDD:214523	219/337 (65%)