Protein Alignment CG4238 and UBE3C

DIOPT Version :9

• Sequence 1: NP_001259896.1
• Gene: CG4238 / 33377
• FlyBaseID: FBgn0031384
• Length: 977
• Species: Drosophila melanogaster
• Sequence 2: NP_055486.2
• Gene: UBE3C / 9690
• HGNCID: 16803
• Length: 1083
• Species: Homo sapiens
• Alignment Length: 537
• Identity: 136/537 - (25%)
• Similarity: 225/537 - (41%)
• Gaps: 86/537 - (16%)

  Fly   488 GVSKNKPRKVLCYVGPKQNSLIFQVTIKEMILKFIPKRIATFRLCPSTKFHFLPQ-------LVS 545
            ||:.:...:....:..|:...:|:|...  ::|.:..|......||..  |:|.:       .|:
Human   580 GVTTSSEMQQCIQMEQKRWIQLFKVITN--LVKMLKSRDTRRNFCPPN--HWLSEQEDIKADKVT 640

  Fly   546 QLH----------------GPV-FIIDDGAQPKIELASKDRNIIAATFTHFLLKNIGGSETFKDK 593
            ||:                ||: ..:|.|.:......|::|.:...|...|::.
Human   641 QLYVPASRHVWRFRRMGRIGPLQSTLDVGLESPPLSVSEERQLAVLTELPFVVP----------- 694

  Fly   594 QDFFYHEVRKFHASYYHEKMALK------------VQREKILESSMKAVKGFSVSDWCGNFEVTF 646
               |...|:.|....|.:|..::            ::|..|.|.:...:...:..|......|..
Human   695 ---FEERVKIFQRLIYADKQEVQGDGPFLDGINVTIRRNYIYEDAYDKLSPENEPDLKKRIRVHL 756

  Fly   647 QG-----EQGIDWGGLRREWFELVCSALFDARGGLFCTFHDKHQALVHPNPTRPAHLKL-----K 701
            ..     |.|||.||:.||:...:..:.|:...|.|.|   .::.|::|||.  |.:.:     :
Human   757 LNAHGLDEAGIDGGGIFREFLNELLKSGFNPNQGFFKT---TNEGLLYPNPA--AQMLVGDSFAR 816

  Fly   702 HFEFAGKMVGKCLFESALGGTYRQLVRARFSRSFLAQLIGLR--VHYKYFEQDDPDLYLSKIKYI 764
            |:.|.|:|:||.|:|:       .||...|:..||::|:|..  |...:....||::|  |....
Human   817 HYYFLGRMLGKALYEN-------MLVELPFAGFFLSKLLGTSADVDIHHLASLDPEVY--KNLLF 872

  Fly   765 LDTDLDATDTLELYFVEEMYDSSSGQLSKTIELIPNGAKTRVTNATKNQYLDALAQQRLCNNVKD 829
            |.:..|..:.|.|.|.....|....|:   :||...|....||:|.:..|:..:|..||...::.
Human   873 LKSYEDDVEELGLNFTVVNNDLGEAQV---VELKFGGKDIPVTSANRIAYIHLVADYRLNRQIRQ 934

  Fly   830 EVDSFLKGLNSIIPDNLLSIFDENELELLMCGTG-EYSISDFKAHHIANGNSAEFRRVLAWFWAG 893
            ...:|.:||.:::....|.:||:.|:::|:.|.. ..|:.|.|:....:|..:....|:..||..
Human   935 HCLAFRQGLANVVSLEWLRMFDQQEIQVLISGAQVPISLEDLKSFTNYSGGYSADHPVIKVFWRV 999

  Fly   894 VSNFSQTEMARLLQFTTGCSQLPPGGFQELNPQFQI-TAAPTFGNLPTAHTCFNQLCLPDYESYE 957
            |..|:..|..:||:|.|.||:.|..||:||.|.|.| ........||||.||.|.|.||::....
Human  1000 VEGFTDEEKRKLLKFVTSCSRPPLLGFKELYPAFCIHNGGSDLERLPTASTCMNLLKLPEFYDET 1064

  Fly   958 QFEKSLLLAISEGSEGF 974
            .....||.|| |.:.||
Human  1065 LLRSKLLYAI-ECAAGF 1080

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4238	NP_001259896.1	IG_FLMN	238..336	CDD:214720
		Filamin	238..336	CDD:279024
		HECTc	615..975	CDD:238033	109/386 (28%)
		HECTc	642..974	CDD:214523	103/345 (30%)
UBE3C	NP_055486.2	Cis-determinant of acceptor ubiquitin-binding	1..60
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..40
		IQ	47..64	CDD:197470
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	355..385
		HECTc	725..1081	CDD:238033	109/374 (29%)
		HECTc	747..1080	CDD:214523	104/350 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810