DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4238 and BAG3

DIOPT Version :9

Sequence 1:	NP_001259896.1	Gene:	CG4238 / 33377	FlyBaseID:	FBgn0031384	Length:	977	Species:	Drosophila melanogaster
Sequence 2:	NP_004272.2	Gene:	BAG3 / 9531	HGNCID:	939	Length:	575	Species:	Homo sapiens

Alignment Length:	195	Identity:	43/195 - (22%)
Similarity:	61/195 - (31%)	Gaps:	67/195 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 SMGISSLSSCGDPERLPELPPLDEQRLQRAA----LHLQQKLILREWLKDHRLQHHYQRLLAVEV 133
            |.|.|||.|...|.....:|.:.||.:.|.|    .|..||.             ||..... |.
Human   190 SSGRSSLGSHQLPRGYISIPVIHEQNVTRPAAQPSFHQAQKT-------------HYPAQQG-EY 240

  Fly   134 ASLEDVYWLEDSRASKILGKDWQ--------------LWSGARQNLPT-SKAQLDALKAQLWSTV 183
            .:.:.||       .||.|.||:              ..:.:|:..|. |...|.:.......||
Human   241 QTHQPVY-------HKIQGDDWEPRPLRAASPFRSSVQGASSREGSPARSSTPLHSPSPIRVHTV 298

  Fly   184 VKSSQ----HQDAWTWGGMLVVSVSVAGLVTLAAMTQPSLAPEARHSLLQYVTGKYLLPANCKVQ 244
            |...|    |::.                   |.::||...||::..    ..|..|.|.:..:|
Human   299 VDRPQQPMTHRET-------------------APVSQPENKPESKPG----PVGPELPPGHIPIQ 340

Fly 245 244
Human 341 340

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4238	NP_001259896.1	IG_FLMN	238..336	CDD:214720	2/7 (29%)
		Filamin	238..336	CDD:279024	2/7 (29%)
		HECTc	615..975	CDD:238033
		HECTc	642..974	CDD:214523
BAG3	NP_004272.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..92
		WW	21..53	CDD:197736
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	123..200		6/9 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	240..421		25/131 (19%)
		BAG	421..498	CDD:214591
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	532..575
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900