DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4238 and TRIP12

DIOPT Version :9

Sequence 1:	NP_001259896.1	Gene:	CG4238 / 33377	FlyBaseID:	FBgn0031384	Length:	977	Species:	Drosophila melanogaster
Sequence 2:	XP_024308991.1	Gene:	TRIP12 / 9320	HGNCID:	12306	Length:	2092	Species:	Homo sapiens

Alignment Length:	1282	Identity:	257/1282 - (20%)
Similarity:	407/1282 - (31%)	Gaps:	455/1282 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 DASLRSDLVLIRSFVVYKGRPPDHATRFDISMLVS----HINVG--------------------- 49
            ||.|..|::            .:||....|:.::|    .|.||
Human   946 DAELLKDVL------------KNHAVSSHIASMLSSQDLKIVVGALQMAEILMQKLPDIFSVYFR 998

  Fly    50 --GVMHAA---TGGKTFPTLKVKLC------FGESMGISSLSSCGDPERLPELPPLDEQRLQRAA 103
              ||||..   ...::..|...|.|      .|.:..:||.::........:|.....|..:..:
Human   999 REGVMHQVKHLAESESLLTSPPKACTNGSGSMGSTTSVSSGTATAATHAAADLGSPSLQHSRDDS 1063

  Fly   104 LHLQQKLILREWLKDHRLQHHYQRLLAVEVASLEDVYWLEDSRASKILGKDWQLWSGARQNLPTS 168
            |.|..:..|.:.||..||.....|.........:|          |:   |.|..|......|.|
Human  1064 LDLSPQGRLSDVLKRKRLPKRGPRRPKYSPPRDDD----------KV---DNQAKSPTTTQSPKS 1115

  Fly   169 KAQLDALKAQLW---STVVKSSQHQDAWTWGGMLVVSVSVAGLVTLAAMTQPS--------LAPE 222
             :.|.:|..:.|   ||...|:..:.|.|.||        :||...|:....|        ...|
Human  1116 -SFLASLNPKTWGRLSTQSNSNNIEPARTAGG--------SGLARAASKDTISNNREKIKGWIKE 1171

  Fly   223 ARHSLLQYVTGKYLLPANCKVQWDWKDPASVGGTMCFVVRFFQRNGQPYPIC-DTDHFFVEVTEG 286
            ..|..::    :|....|    .|..:||         :...||      :| .|:...::|..|
Human  1172 QAHKFVE----RYFSSEN----MDGSNPA---------LNVLQR------LCAATEQLNLQVDGG 1213

  Fly   287 TRKVVTISELGSSTDPNNANIAKVKFTVRTAGQYKISVLIGAS-----------------HIAGS 334
            ...:|.|..:.|.:|.::       |.::.:|..|..:|...|                 |:
Human  1214 AECLVEIRSIVSESDVSS-------FEIQHSGFVKQLLLYLTSKSEKDAVSREIRLKRFLHV--- 1268

  Fly   335 PFLRSFLPGAIDARRSRFIRPASTVICCAGAPTLMHIEPRDEFGNSCLFDQNQSDEALQGYQVAI 399
             |..|.|||.         .|...|.....||.|..:...    |:||....|       :.|.:
Human  1269 -FFSSPLPGE---------EPIGRVEPVGNAPLLALVHKM----NNCLSQMEQ-------FPVKV 1312

  Fly   400 YDL---HGVPVEKLQHAIVFAYDKVNSRVSVTALFPEPTC------------------LRAVISY 443
            :|.   :|......| |:.|    .|:......|...|.|                  ::|:..|
Human  1313 HDFPSGNGTGGRGSQ-ALKF----FNTHQLKCQLQRHPDCANVKQWKGGPVKIDPLALVQAIERY 1372

  Fly   444 -------------RDQQLPNGDFDIIVLSSSDTTLVHKNIASRKHNICYEAKLLSI--------- 486
                         .|......|.:|      |.:||...|.: .:|:.|:.:.|.:
Human  1373 LVVRGYGRVREDDEDSDDDGSDEEI------DESLVRYYIPT-MYNVLYKVQGLWLKWLLLCFIQ 1430

  Fly   487 ---FGVSKNKPRKVLCYVGPKQNSLIFQVTIKEMILKFI----PKRIAT-------FRLCPSTKF 537
               |..|.|...::..|:|  ::.|.:.:|:.:.:.:|.    .:|.:|       .|....||.
Human  1431 AAQFLNSGNVRHRLQFYIG--EHLLPYNMTVYQAVRQFSIQAEDERESTDDESNPLGRAGIWTKT 1493

  Fly   538 HFL--------------------------PQLVS----QLHGPVFIIDDGAQPKIE-------LA 565
            |.:                          |...|    :.|..::  .||..|.:.       :.
Human  1494 HTIWYKPVREDEESNKDCVGGKRGRAQTAPTKTSPRNAKKHDELW--HDGVCPSVSNPLEVYLIP 1556

  Fly   566 SKDRNI-----------------IAATFTHFLLKN------IGGSETFKDK---------QD--- 595
            :...||                 ..:.:.::|..|      |..||....|         ||
Human  1557 TPPENITFEDPSLDVILLLRVLHAISRYWYYLYDNAMCKEIIPTSEFINSKLTAKANRQLQDPLV 1621

  Fly   596 -------------------FFYHEVRK--FHASYYHEKMALK----------------------- 616
                               ||..:.|:  |:.:.:....|::
Human  1622 IMTGNIPTWLTELGKTCPFFFPFDTRQMLFYVTAFDRDRAMQRLLDTNPEINQSDSQDSRVAPRL 1686

  Fly   617 ------VQREKILESSMKAVKGFSVSDWCGNFEVTFQGEQGIDWGGLRREWFELVCSALFDA--- 672
                  |.||::|:.:...::....|.  ...|:.::.|.|...|. ..|::.||...|..|
Human  1687 DRKKRTVNREELLKQAESVMQDLGSSR--AMLEIQYENEVGTGLGP-TLEFYALVSQELQRADLG 1748

  Fly   673 --RG----------------------GLFCTFHDKHQALVHPNPTRPAHL---KLKHFEFAGKMV 710
              ||                      |||        ||......:|||:   |:| |.|.||::
Human  1749 LWRGEEVTLSNPKGSQEGTKYIQNLQGLF--------ALPFGRTAKPAHIAKVKMK-FRFLGKLM 1804

  Fly   711 GKCLFESALGGT------YRQLVRARFSRSF-----LAQLIGLRVHY--------KYFEQDDPDL 756
            .|.:.:..|...      |:.::|...|.:.     :..::...|::        |..|||....
Human  1805 AKAIMDFRLVDLPLGLPFYKWMLRQETSLTSHDLFDIDPVVARSVYHLEDIVRQKKRLEQDKSQT 1869

  Fly   757 YLSKIKYILDT---------DLDATDTLELYFVEEMYDSSSGQLSKTIELIPNGAKTRVTNATKN 812
            ..| ::|.|:|         ||....||..:              ..|||...|....||.....
Human  1870 KES-LQYALETLTMNGCSVEDLGLDFTLPGF--------------PNIELKKGGKDIPVTIHNLE 1919

  Fly   813 QYLDALAQQRLCNNVKDEVDSFLKGLNSIIPDNLLSIFDENELELLMCGTGEYSISDFKA----- 872
            :||..:....|...|..:.|||..|..|:.|.:.|..|...||:.|:||: :....|.|.
Human  1920 EYLRLVIFWALNEGVSRQFDSFRDGFESVFPLSHLQYFYPEELDQLLCGS-KADTWDAKTLMECC 1983

  Fly   873 ---HHIANGNSAEFRRVLAWFWAGVSNFSQTEMARLLQFTTGCSQLPPGGFQELNPQFQITAAPT 934
               |...:.:     |.:.:.:..:|:|...:....|||.||..:||.|||:.|||...| ...|
Human  1984 RPDHGYTHDS-----RAVKFLFEILSSFDNEQQRLFLQFVTGSPRLPVGGFRSLNPPLTI-VRKT 2042

  Fly   935 FGN-------LPTAHTCFNQLCLPDYESYEQFEKSLLLAISEGSEGF 974
            |.:       ||:..||.|.|.||||.|.|...:.||:|..||.:.|
Human  2043 FESTENPDDFLPSVMTCVNYLKLPDYSSIEIMREKLLIAAREGQQSF 2089

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4238	NP_001259896.1	IG_FLMN	238..336	CDD:214720	20/115 (17%)
		Filamin	238..336	CDD:279024	20/115 (17%)
		HECTc	615..975	CDD:238033	111/462 (24%)
		HECTc	642..974	CDD:214523	105/404 (26%)
TRIP12	XP_024308991.1	SR-25	99..>233	CDD:313680
		Arm_3	489..>714	CDD:330530
		WWE	808..874	CDD:308464
		HECTc	1690..2090	CDD:238033	111/434 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900