DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4238 and HERC3

DIOPT Version :9

Sequence 1:	NP_001259896.1	Gene:	CG4238 / 33377	FlyBaseID:	FBgn0031384	Length:	977	Species:	Drosophila melanogaster
Sequence 2:	NP_055421.1	Gene:	HERC3 / 8916	HGNCID:	4876	Length:	1050	Species:	Homo sapiens

Alignment Length:	369	Identity:	89/369 - (24%)
Similarity:	158/369 - (42%)	Gaps:	26/369 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   613 MALKVQREKILESSMKAVKGFSVSDWCGNFEVTFQGEQGIDWGGLRREWFELVCSALFDARGGLF 677
            :.|.|:|..::..:::.:...|..|.....:|.|.||:.:|.||:.:|:|.|:...|.:...|:|
Human   702 LVLHVRRNNLVGDALRELSIHSDIDLKKPLKVIFDGEEAVDAGGVTKEFFLLLLKELLNPIYGMF 766

  Fly   678 CTFHDKHQALVHPNPTRPAHLKLKHFEFAGKMVGKCLFESALGGTYRQLVRARFSRSFLAQLIGL 742
            ..:.|.:  |:..:.|  ..::...|...|...|..::.|.       :|...|..:...:|:.:
Human   767 TYYQDSN--LLWFSDT--CFVEHNWFHLIGITCGLAIYNST-------VVDLHFPLALYKKLLNV 820

  Fly   743 RVHYKYFEQDDPDLYLSKIKYILD---TDLDATDTLELYFVEEMYDSSSGQLSKTIELIPNGAKT 804
            :...:..::..|....| ::.:||   .|::.|..|......|.|    |.:.:. :|||.|...
Human   821 KPGLEDLKELSPTEGRS-LQELLDYPGEDVEETFCLNFTICRESY----GVIEQK-KLIPGGDNV 879

  Fly   805 RVTNATKNQYLDALAQQRLCNNVKDEVDSFLKGLNSIIPDNLLSIFDENELELLMCGTGEYSISD 869
            .|....:.:::||........:|.:...:|..|...:....:|.:|..:||..:|.|...|:..:
Human   880 TVCKDNRQEFVDAYVNYVFQISVHEWYTAFSSGFLKVCGGKVLELFQPSELRAMMVGNSNYNWEE 944

  Fly   870 FKAHHIANGNSAEFRRVLAWFWAGVSNFSQTEMARLLQFTTGCSQLPPGGFQELNPQFQITAAPT 934
            .:...|..|:.:.....:..||.....|...:..:.|.|.||..::|..|...|....|.||:
Human   945 LEETAIYKGDYSATHPTVKLFWETFHEFPLEKKKKFLLFLTGSDRIPIYGMASLQIVIQSTAS-- 1007

  Fly   935 FGN--LPTAHTCFNQLCLPDYESYEQFEKSLLLAISEGSEGFGM 976
             |.  ||.||||:|.|.||.|.|.|.....|..|: :..|||.:
Human  1008 -GEEYLPVAHTCYNLLDLPKYSSKEILSARLTQAL-DNYEGFSL 1049

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4238	NP_001259896.1	IG_FLMN	238..336	CDD:214720
		Filamin	238..336	CDD:279024
		HECTc	615..975	CDD:238033	88/364 (24%)
		HECTc	642..974	CDD:214523	82/336 (24%)
HERC3	NP_055421.1	RCC1 1	1..51
		ATS1	2..331	CDD:227511
		RCC1 2	52..101
		RCC1 3	102..154
		RCC1 4	156..207
		RCC1 5	208..259
		RCC1 6	261..311
		RCC1	313..377	CDD:366085
		RCC1 7	313..366
		HECTc	702..1048	CDD:238033	88/366 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810