DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4238 and RSP5

DIOPT Version :9

Sequence 1:	NP_001259896.1	Gene:	CG4238 / 33377	FlyBaseID:	FBgn0031384	Length:	977	Species:	Drosophila melanogaster
Sequence 2:	NP_011051.3	Gene:	RSP5 / 856862	SGDID:	S000000927	Length:	809	Species:	Saccharomyces cerevisiae

Alignment Length:	492	Identity:	144/492 - (29%)
Similarity:	240/492 - (48%)	Gaps:	85/492 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   523 PKRIATFRLCPSTKFHFLPQLVSQLHGP--------------VFIIDDGAQ------PKIELASK 567
            |:|....|....|......|.|||| ||              |:.:|...:      |::. :|.
Yeast   362 PRRQQYIRTYGPTNTTIQQQPVSQL-GPLPSGWEMRLTNTARVYFVDHNTKTTTWDDPRLP-SSL 424

  Fly   568 DRNIIAATFTHFLLKNIGGSETFKDKQDFFYHEVRKFHASYYHEKMAL---------KVQREKIL 623
            |:|:.                  :.|:||      :....|:..:.||         ||:|:.|.
Yeast   425 DQNVP------------------QYKRDF------RRKVIYFRSQPALRILPGQCHIKVRRKNIF 465

  Fly   624 ESSMKAVKGFSVSDWCGNFEVTFQGEQGIDWGGLRREWFELVCSALFDARGGLFCTF----HDKH 684
            |.:.:.:...:..|......:.|.||:|:|:||:.||:|.|:...:|:.   .:|.|    :|.:
Yeast   466 EDAYQEIMRQTPEDLKKRLMIKFDGEEGLDYGGVSREFFFLLSHEMFNP---FYCLFEYSAYDNY 527

  Fly   685 QALVHPNP-TRPAHLKLKHFEFAGKMVGKCLFESALGGTYRQLVRARFSRSFLAQLIGLRVHYKY 748
            ...::||. ..|.|  |.:|:|.|::||       ||..:|:.:.|.|..:....::..:|..:.
Yeast   528 TIQINPNSGINPEH--LNYFKFIGRVVG-------LGVFHRRFLDAFFVGALYKMMLRKKVVLQD 583

  Fly   749 FEQDDPDLYLSKIKYILDTDLDATDTLELYFVEEMYDSSSGQLSKTIELIPNGAKTRVTNATKNQ 813
            .|..|.::| :.:.::|:..:|.  .|:|.|..:  |...|:: .|::|.|:|....||:..|.:
Yeast   584 MEGVDAEVY-NSLNWMLENSIDG--VLDLTFSAD--DERFGEV-VTVDLKPDGRNIEVTDGNKKE 642

  Fly   814 YLDALAQQRLCNNVKDEVDSFLKGLNSIIPDNLLSIFDENELELLMCGTGEYSISDFKAHHIANG 878
            |::...|.|:.:.|:::..:|:.|.|.:||::|:::|||.|||||:.|..|..|.|:|.|....|
Yeast   643 YVELYTQWRIVDRVQEQFKAFMDGFNELIPEDLVTVFDERELELLIGGIAEIDIEDWKKHTDYRG 707

  Fly   879 NSAEFRRVLAWFWAGVSNFSQTEMARLLQFTTGCSQLPPGGFQELN-----PQFQITAAPTFGNL 938
            .. |...|:.|||..||.:...:.|||||||||.|::|..||::|.     .:|.|..|.....|
Yeast   708 YQ-ESDEVIQWFWKCVSEWDNEQRARLLQFTTGTSRIPVNGFKDLQGSDGPRRFTIEKAGEVQQL 771

  Fly   939 PTAHTCFNQLCLPDYESYEQFEKSLLLAISEGSEGFG 975
            |.:|||||::.||.|..|:..::.|.||:.| :.|||
Yeast   772 PKSHTCFNRVDLPQYVDYDSMKQKLTLAVEE-TIGFG 807

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4238	NP_001259896.1	IG_FLMN	238..336	CDD:214720
		Filamin	238..336	CDD:279024
		HECTc	615..975	CDD:238033	120/378 (32%)
		HECTc	642..974	CDD:214523	112/341 (33%)
RSP5	NP_011051.3	HUL4	3..809	CDD:227354	144/492 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810