DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4238 and UFD4

DIOPT Version :9

Sequence 1:	NP_001259896.1	Gene:	CG4238 / 33377	FlyBaseID:	FBgn0031384	Length:	977	Species:	Drosophila melanogaster
Sequence 2:	NP_012915.3	Gene:	UFD4 / 853859	SGDID:	S000001493	Length:	1483	Species:	Saccharomyces cerevisiae

Alignment Length:	499	Identity:	117/499 - (23%)
Similarity:	193/499 - (38%)	Gaps:	106/499 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   542 QLVSQLHGPVFIIDDGAQPKIELASK---------DRNIIAATFTHF-------LLKNIGGSETF 590
            :|..||..|: ::..||.|...|...         |..::....|.|       |.||  .|:..
Yeast  1022 KLARQLDEPL-VVASGALPDWSLFLTRRFPFLFPFDTRMLFLQCTSFGYGRLIQLWKN--KSKGS 1083

  Fly   591 KD-KQDFFYHEVRKFHASYYHEKMALKVQREKILESSMKAVKGFSVSDWCGNFEVTFQGEQGIDW 654
            || :.|....::.:.      .:..|::.|:.|..:.:|.:..:..|.  ...|:.:|.|.|...
Yeast  1084 KDLRNDEALQQLGRI------TRRKLRISRKTIFATGLKILSKYGSSP--DVLEIEYQEEAGTGL 1140

  Fly   655 GGLRREWFELVCSALFDARGGL---FC------------TFHDKHQALVHPNPTRP---AHLKLK 701
            |. ..|::.:|  :.:.||..|   .|            |..|....|:.|.|..|   ....::
Yeast  1141 GP-TLEFYSVV--SKYFARKSLNMWRCNSYSYRSEMDVDTTDDYITTLLFPEPLNPFSNNEKVIE 1202

  Fly   702 HFEFAGKMVGKCLFESALGGTYRQLVRARFSRSFLAQL------------IGLRVHYKYFEQDDP 754
            .|.:.|..|.:.|.::       :::..|||:.|...|            ..:.......|..||
Yeast  1203 LFGYLGTFVARSLLDN-------RILDFRFSKVFFELLHRMSTPNVTTVPSDVETCLLMIELVDP 1260

  Fly   755 DLYLSKIKYILDTDLD--ATDTLELYFVEEMYDSSSGQLSKTIELIPNGAKTRVTNATKNQYLDA 817
             |....:|||:....|  ..::|.|.|.....|.        |||||.|....:.::...:|:..
Yeast  1261 -LLAKSLKYIVANKDDNMTLESLSLTFTVPGNDD--------IELIPGGCNKSLNSSNVEEYIHG 1316

  Fly   818 LAQQRLCNNVKDEVDSFLKGLNSI---------IPDNLLSIFDENELELLMCGTGEYSISDFKAH 873
            :..|.|...::.::.:|::|.:.:         .||.|:.||...|.:..|...    .::..|.
Yeast  1317 VIDQILGKGIEKQLKAFIEGFSKVFSYERMLILFPDELVDIFGRVEEDWSMATL----YTNLNAE 1377

  Fly   874 HIANGNSAEFRRVLAWFWAGVSNFSQTEMARLLQFTTGCSQLPPGGFQELNPQFQIT-------- 930
            |....:|:    ::..|.:.:|.|.:.|....|||.||..:||.|||:.|||:|.:.
Yeast  1378 HGYTMDSS----IIHDFISIISAFGKHERRLFLQFLTGSPKLPIGGFKSLNPKFTVVLKHAEDGL 1438

  Fly   931 AAPTFGNLPTAHTCFNQLCLPDYESYEQFEKSLLLAISEGSEGF 974
            .|..:  ||:..||.|.|.||.|.|.:.....|..||.||:..|
Yeast  1439 TADEY--LPSVMTCANYLKLPKYTSKDIMRSRLCQAIEEGAGAF 1480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4238	NP_001259896.1	IG_FLMN	238..336	CDD:214720
		Filamin	238..336	CDD:279024
		HECTc	615..975	CDD:238033	99/409 (24%)
		HECTc	642..974	CDD:214523	93/380 (24%)
UFD4	NP_012915.3	HUL4	581..1482	CDD:227354	117/499 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900