DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4238 and HUL5

DIOPT Version :9

Sequence 1:	NP_001259896.1	Gene:	CG4238 / 33377	FlyBaseID:	FBgn0031384	Length:	977	Species:	Drosophila melanogaster
Sequence 2:	NP_011374.1	Gene:	HUL5 / 852736	SGDID:	S000003109	Length:	910	Species:	Saccharomyces cerevisiae

Alignment Length:	962	Identity:	220/962 - (22%)
Similarity:	363/962 - (37%)	Gaps:	252/962 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   169 KAQLDALKAQLWSTVVKSSQH--------QDAWT----------WGGMLVVSVSVAGLVTLAAMT 215
            :|| |.||.....|:.||.:.        ::.:|          :||.|:..:|...|..|..::
Yeast    37 RAQ-DKLKEDASKTIQKSIRRHFSNVRLFKNTFTSSQLVHMIPAYGGKLIYYISQYDLQQLLKLS 100

  Fly   216 Q-------PSLAPEARHSLLQYVTGKYLLPANCKVQWDWKDPASVGGTM------CFVVRFFQRN 267
            .       .||......|||:.                ::|.|.|..|:      |..|..|..:
Yeast   101 HNFLSSYPNSLGNRQLLSLLKL----------------YQDDALVAETLSDLNMDCPTVDEFLDS 149

  Fly   268 GQPYPICDTDHFFVEVTEGTRKVVTISELGSSTDPNNANIAKVKFTVRTAGQYKI-SVLIGASHI 331
            ...| :|                 ..|.|..|:....|::.:....:.::....| |:.||:  .
Yeast   150 LSVY-LC-----------------RASFLSYSSASKLADVIEAWEVMHSSASISIFSISIGS--Y 194

  Fly   332 AGSPFL---------RSFLPGAIDARRSRFIRPASTVICCAG------APTLM-----HIEPRDE 376
            ...||.         |:.||..|:.....:...|.|...|:.      |..|:     ||.|
Yeast   195 EKRPFALQFYCILAERNLLPQLINTNPILWDNMAKTYSHCSKGGQKNIAKLLIPNFNNHIAP--- 256

  Fly   377 FGNSCLFDQNQSDEALQGYQVAIYDLHGVPVEKLQHAIVFAYDKVNSRVSVTALFPEPTCLRAVI 441
               |.|  ::.:|..|:.|:.|..|    .|.......|...|.|.:.:...|..|..:|..:|:
Yeast   257 ---SVL--RSDNDYVLKFYEKAFID----EVIATTANYVSDEDHVKNLMCYIASSPNQSCKNSVL 312

  Fly   442 SYRDQQLPNGDFDIIVLSSSDTT------LVHKNIASRK---HNICYEAKLLSIFGVSKNKPRKV 497
                         |.:||:.|..      ..|....:.|   |.:......|....:..:..|::
Yeast   313 -------------ITLLSNKDFVRRLSWEFFHTKFNASKTEAHPLFSVLAQLIDMHLLISTDREL 364

  Fly   498 LCYVGPKQNSLI-------FQVTIKE----------------MILKFIPKRIATFRLCPSTKFHF 539
            |.|     ||:|       |..|:|:                |:.:.:|.....:.  ..::.||
Yeast   365 LDY-----NSVIPIEELKKFTSTLKDFTFRQYWELPKSERNPMLKEAVPLLSKVYE--RDSRLHF 422

  Fly   540 LPQLVSQLHGPVF------------------------------IIDDGAQPKIELASKDRNIIAA 574
            |    |..:.|.:                              ..|:..:.:|:| .|:|..:.:
Yeast   423 L----STENNPTYWENSEKQFLNLRFYEELQEYEDLYREHLEEESDEDMEKEIDL-DKERPPLKS 482

  Fly   575 TFTHFLLKNIGGSETFK---------------DKQDFFY---------------HEVRKFH---A 606
            ...:.:.|.:..|..|:               ::.|.||               |.:....   |
Yeast   483 LLLNKMKKRLKSSLRFRKLEILLELPFFIPFEERVDLFYMFIALDKKRLSLDDDHNLINMFTPWA 547

  Fly   607 SYYHEKMALKVQREKILESSMKAVKGFSVSD-WCGNFEVTFQG----EQGIDWGGLRREWFELVC 666
            |....|.:..:.|:.:||.:..|..  |:.: :..:.:|||..    |.|||.||:.:|:...|.
Yeast   548 STGMRKQSAIISRDNVLEDAFNAFN--SIGERFKASLDVTFINEFGEEAGIDGGGITKEFLTTVS 610

  Fly   667 SALF-DARGGLFCTFHDKHQALVHPNPTRPAHLKLKHFEFAGKMVGKCLFESALGGTYRQLVRAR 730
            ...| |.:..||.| :|:::  ::|:....| .|||:..|.||:|||||:|..       |:...
Yeast   611 DEGFKDPKHELFRT-NDRYE--LYPSVVYDA-TKLKYIWFLGKVVGKCLYEHV-------LIDVS 664

  Fly   731 FSRSFLAQLI----GLRVHYKYFEQDDPDLYLSKIKYILDTDLDATDTLELYFVEEMYDSSSGQL 791
            |:..||.:|:    |....:......|..||.:.|| :|:...|...:|:|.|..:..:||
Yeast   665 FADFFLKKLLNYSNGFLSSFSDLGSYDSVLYNNLIK-LLNMTTDEIKSLDLTFEIDEPESS---- 724

  Fly   792 SKTIELIPNGAKTRVTNATKNQYLDALAQQRLCNNVKDEVDSFLKGLNSIIPDNLLSIFDENELE 856
            :|.::|||||:||.||......|:..:...:|.......|.:|..||:.||..:.:.:|:..||:
Yeast   725 AKVVDLIPNGSKTYVTKDNVLLYVTKVTDYKLNKRCFKPVSAFHGGLSVIIAPHWMEMFNSIELQ 789

  Fly   857 LLMCGTGE-YSISDFKAHHIANGNSAEFRRVLAWFWAGVSNFSQTEMARLLQFTTGCSQLPPGGF 920
            :|:.|..: ..:.|.|::....|...|.:.::. ||..::.|...|....|:|.|...|.|..||
Yeast   790 MLISGERDNIDLDDLKSNTEYGGYKEEDQTIVD-FWEVLNEFKFEEKLNFLKFVTSVPQAPLQGF 853

  Fly   921 QELNPQFQITAAPTFG-NLPTAHTCFNQLCLPDYESYEQFEKSLLLAISEGS 971
            :.|:|:|.|..|.|.. .||||.||.|.|.||||.:.....:.||.||:.|:
Yeast   854 KALDPKFGIRNAGTEKYRLPTASTCVNLLKLPDYRNKTILREKLLYAINSGA 905

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4238	NP_001259896.1	IG_FLMN	238..336	CDD:214720	17/104 (16%)
		Filamin	238..336	CDD:279024	17/104 (16%)
		HECTc	615..975	CDD:238033	115/369 (31%)
		HECTc	642..974	CDD:214523	110/341 (32%)
HUL5	NP_011374.1	HUL4	35..910	CDD:227354	220/962 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810