DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4238 and GAS7

DIOPT Version :9

Sequence 1:	NP_001259896.1	Gene:	CG4238 / 33377	FlyBaseID:	FBgn0031384	Length:	977	Species:	Drosophila melanogaster
Sequence 2:	NP_958839.1	Gene:	GAS7 / 8522	HGNCID:	4169	Length:	476	Species:	Homo sapiens

Alignment Length:	299	Identity:	61/299 - (20%)
Similarity:	103/299 - (34%)	Gaps:	77/299 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   570 NIIAATFTHFLLKNIGGSETFKDKQDFFYHEVRKFHASYYHEKMALKVQREKILESSMKAVKGFS 634
            |...|.|...|.|.:.|.:..|:..:|    :|               :|.||.|...|.:...|
Human   214 NGTVAGFELLLQKQLKGKQMQKEMSEF----IR---------------ERIKIEEDYAKNLAKLS 259

  Fly   635 VSDWCGNFEVTFQGEQGIDWGGLRREWFELVCSALFDARGGLFCTFHDKHQALVHPNPTRPAHLK 699
            .:......|           |.|...|.::..|...:|.      .|.|..|.:|....:|....
Human   260 QNSLASQEE-----------GSLGEAWAQVKKSLADEAE------VHLKFSAKLHSEVEKPLMNF 307

  Fly   700 LKHFEFAGKMVGKCLFESA-----LGGTYRQLVRAR---FSRSFLAQLIGLRVHYKYFEQDDPDL 756
            .::|:   |.:.||....|     |...|..:.:||   ..|....::...::..|...:.:.|:
Human   308 RENFK---KDMKKCDHHIADLRKQLASRYASVEKARKALTERQRDLEMKTQQLEIKLSNKTEEDI 369

  Fly   757 YLSKIKYILDTDLDATDTLELY------FVEEMYDSSSGQLSKTIELIPNGAKTRVTNATKNQYL 815
            ..::.|.....| |....::||      :.|||       ::.|:||    .:..|...
Human   370 KKARRKSTQAGD-DLMRCVDLYNQAQSKWFEEM-------VTTTLEL----ERLEVERV------ 416

  Fly   816 DALAQQRLC--NNVKDEVDSFLKGLNSIIP-DNLLSIFD 851
             .:.:|.||  ..::.|.|.|  ..:::.| |.||...|
Human   417 -EMIRQHLCQYTQLRHETDMF--NQSTVEPVDQLLRKVD 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4238	NP_001259896.1	IG_FLMN	238..336	CDD:214720
		Filamin	238..336	CDD:279024
		HECTc	615..975	CDD:238033	52/254 (20%)
		HECTc	642..974	CDD:214523	46/227 (20%)
GAS7	NP_958839.1	SH3_GAS7	5..57	CDD:212763
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	100..171
		WW_FCH_linker	109..201	CDD:374680
		F-BAR_GAS7	214..446	CDD:153333	57/291 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900