DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4238 and UPL1

DIOPT Version :9

Sequence 1:	NP_001259896.1	Gene:	CG4238 / 33377	FlyBaseID:	FBgn0031384	Length:	977	Species:	Drosophila melanogaster
Sequence 2:	NP_001185245.1	Gene:	UPL1 / 842036	AraportID:	AT1G55860	Length:	3681	Species:	Arabidopsis thaliana

Alignment Length:	1105	Identity:	288/1105 - (26%)
Similarity:	442/1105 - (40%)	Gaps:	286/1105 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 DPERLPELPP------LDEQRLQRAALHLQQKLI--------------LRE-------------- 114
            |||.|..|||      |.:||.||.....|.:.:              |||
plant  2648 DPEFLAALPPDIQTEVLAQQRAQRMVQQSQGQAVDMDNASIIATLPADLREEVLLTSSEAVLAAL 2712

  Fly   115 ---------WLKDHRLQHHYQRLLAVEVASLEDVYWLEDSR----ASKILGKDWQLWSGARQNLP 166
                     .|:| |...|||...:|..:|    :.|.:.|    .:::.|.|..:.....|...
plant  2713 PSPLLAEAQMLRD-RAMSHYQARSSVFGSS----HRLNNRRNGLGYNRLTGMDRGVGVTIGQRAV 2772

  Fly   167 TSKAQLDALKAQLWSTVVKSSQHQDAWTWGGMLVVSVSVAGLVTLAAMTQP--------SLAPEA 223
            :|.|  |.||       ||..:       |..||.:.::..|:.|..:.||        .|....
plant  2773 SSSA--DGLK-------VKEIE-------GDPLVNADALKSLIRLLRLAQPLGKGLLQRLLLNLC 2821

  Fly   224 RHSLLQYVTGKYLL----------PANCKVQWDWKDPASVGGTMCFVV--RFFQRNGQPYPI--- 273
            .||..:....:.||          |:...:    .:|..:.|....||  |....||.| |:
plant  2822 AHSFTRANLVQLLLDMIRPEMETSPSELAI----TNPQRLYGCQSNVVYGRSQLLNGLP-PLVFR 2881

  Fly   274 --------CDTDH-------FFVEVT--------EGTRKVVTISELGSSTDPNNANIAKVKFTV- 314
                    ..|:|       |:.:.:        :|..||..:      ||..:..|..|.|..
plant  2882 RVLEVLTYLATNHSAVADMLFYFDSSLLSQLSSRKGKEKVTHV------TDSRDLEIPLVVFLKL 2940

  Fly   315 --------------RTAGQYKISVLIGASHIAG-SPFLRSFLPGAIDAR--------------RS 350
                          ...|..::.|...||.|.| ||  .|.:|..::.:              .|
plant  2941 LNRPQLLQSTSHLGLVMGLLQVVVYTAASRIEGWSP--SSGVPEKLENKPVGEEASSETRKDAES 3003

  Fly   351 RFIRPASTVIC----CAGAPTLMHIEPRDEFGNSCLFDQNQSDEALQGYQ---VAIYDLHGVPVE 408
            ..:..|...:.    ||....:....|:.:..|.|:         |.||:   ..||.|.|..::
plant  3004 ELVGEADLSVARRKNCAEIYNIFLQLPQSDLCNLCI---------LLGYEGLSDKIYSLAGEVLK 3059

  Fly   409 KLQHAIVFAYDK-VNSRVSVTALFPEPTCLRAVISYRDQQLPNGDFD----------IIVLSSSD 462
            ||. |:..|:.| ....:|..|.....:.:|.:.:...:|..:....          :.||||..
plant  3060 KLA-AVDVAHRKFFTKELSELASSLSSSTVRELATLSSKQKMSRSTGSMAGASILRVLQVLSSLT 3123

  Fly   463 TTLVHKNIASRKHNICYEAKLLSIFGVSKNKPRKVLCYVGPKQNSLIFQVTIKEM---------- 517
            :.:...|:.:.:.....|..::....|:          :.|..:.|...:::.|:
plant  3124 SPIDESNVGTERETEQEEQNIMQRLNVA----------LEPLWHELSQCISMTELQLDHTAAASN 3178

  Fly   518 ------ILKFIPKRI---ATFRLCPSTKFHFLPQLVSQLHGPVFIIDD--------------GAQ 559
                  :|...|...   .|.||.|..:..|:  |..::..|..:..|              |:.
plant  3179 INPGDHVLGISPTSSLSPGTQRLLPLIEAFFV--LCEKIQTPSMLQQDTNVTAGEVKESSAHGSS 3241

  Fly   560 PKIELASKDRNIIAATFTHFLLKN-------IGGSET-----------------FKDKQDFFYHE 600
            .|..:.|:.:...:.||:.|..|:       |..:.:                 |.:|:.:|...
plant  3242 SKTSVDSQKKTDGSVTFSKFAEKHRRLLNSFIRQNPSLLEKSLSMMLKAPRLIDFDNKKAYFRSR 3306

  Fly   601 VRKFHASYYHEKMALKVQREKILESSMKAVKGFSVSDWCGNFEVTFQGEQGIDWGGLRREWFELV 665
            :|..|..:....:.:.|:|..:||.|...::..|..|..|...|.||||:|||.|||.|||::|:
plant  3307 IRHQHDQHISGPLRISVRRAYVLEDSYNQLRMRSPQDLKGRLNVQFQGEEGIDAGGLTREWYQLL 3371

  Fly   666 CSALFDARGGLFCTFHDKHQALVHPNPT---RPAHLKLKHFEFAGKMVGKCLFESALGGTYRQLV 727
            ...:||....||.|.  .:.|...|||.   :..|  |.:|:|.|:||.|.||:.       ||:
plant  3372 SRVIFDKGALLFTTV--GNDATFQPNPNSVYQTEH--LSYFKFVGRMVAKALFDG-------QLL 3425

  Fly   728 RARFSRSFLAQLIGLRVHYKYFEQDDPDLYLSKIKYILDTDLDATDTLELYFVEEMYDSSSGQLS 792
            ...|:|||...::|::|.|...|..||| |...:|::|:.|:  :|.|:|.|..:..:.......
plant  3426 DVYFTRSFYKHILGVKVTYHDIEAVDPD-YYKNLKWLLENDV--SDILDLTFSMDADEEKHILYE 3487

  Fly   793 KT----IELIPNGAKTRVTNATKNQYLDALAQQRLCNNVKDEVDSFLKGLNSIIPDNLLSIFDEN 853
            ||    .||.|.|...|||..||::|:|.:|...|.|.::.::::||:|.|.:||..|:|||::.
plant  3488 KTEVTDYELKPGGRNIRVTEETKHEYVDLVAGHILTNAIRPQINAFLEGFNELIPRELVSIFNDK 3552

  Fly   854 ELELLMCGTGEYSISDFKAHHIANGNSAEFRRVLAWFWAGVSNFSQTEMARLLQFTTGCSQLPPG 918
            |||||:.|..|....|.||:......:|. ..|:.|||..|..||:.:|||.|||.||.|::|..
plant  3553 ELELLISGLPEIDFDDLKANTEYTSYTAG-SPVIHWFWEVVKAFSKEDMARFLQFVTGTSKVPLE 3616

  Fly   919 GFQEL----NPQ-FQITAAPTFG---NLPTAHTCFNQLCLPDYESYEQFEKSLLLAISEGSEGFG 975
            ||:.|    .|| .||..|  :|   .||:||||||||.||:|:|.||.::.|||||.|.|||||
plant  3617 GFKALQGISGPQRLQIHKA--YGAPERLPSAHTCFNQLDLPEYQSKEQLQERLLLAIHEASEGFG 3679

Fly 976 975
plant 3680 3679

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4238	NP_001259896.1	IG_FLMN	238..336	CDD:214720	28/141 (20%)
		Filamin	238..336	CDD:279024	28/141 (20%)
		HECTc	615..975	CDD:238033	151/374 (40%)
		HECTc	642..974	CDD:214523	142/346 (41%)
UPL1	NP_001185245.1	DUF908	88..358	CDD:283630
		DUF913	416..763	CDD:283642
		UBA_atUPL1_2_like	1273..1310	CDD:270512
		DUF4414	2609..2704	CDD:291075	16/55 (29%)
		HECTc	3319..3679	CDD:238033	151/376 (40%)
		HECTc	3343..3678	CDD:214523	144/351 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11254
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.870