DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4238 and herc5.2

DIOPT Version :9

Sequence 1:	NP_001259896.1	Gene:	CG4238 / 33377	FlyBaseID:	FBgn0031384	Length:	977	Species:	Drosophila melanogaster
Sequence 2:	XP_005160175.1	Gene:	herc5.2 / 794323	ZFINID:	ZDB-GENE-090311-16	Length:	987	Species:	Danio rerio

Alignment Length:	1003	Identity:	201/1003 - (20%)
Similarity:	330/1003 - (32%)	Gaps:	320/1003 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   148 SKILGKDWQL--WSGARQNLPTSKAQLDALKAQLWSTVVKSSQHQDAWTWGGMLVVSVSVAGLVT 210
            |..|..|.||  |.      ..:..||...|.|   .:::|.||..:..  |:.|..:|..|
Zfish   130 SVALSNDGQLFVWG------ENAHGQLGLRKEQ---ALIQSPQHLQSLC--GIPVAQISAGG--- 180

  Fly   211 LAAMTQPSLAPEARHSLLQYVTGKYLLPANCKVQWDWKDPAS----VGGTMCFVVRFFQRNGQPY 271
                         .||.:..::|         |.:.|...::    :|.|
Zfish   181 -------------NHSFVLSLSG---------VVFGWGSNSAGQLGLGDT--------------- 208

  Fly   272 PICDTDHFFVEVTEGT--RKVVTISELGSSTDPNNANIAK--VKFTVRTAG-------------- 318
                ||.|...:.:..  :|.|:||..|..|    |.::|  ..||..:.|
Zfish   209 ----TDRFVPTIVKSLSGKKTVSISCGGEHT----ATLSKGGTVFTFGSGGFGQLGHNSLKDEHH 265

  Fly   319 --------QYKIS-VLIGASH----IAGSPFLRSF-------LPGAIDARRSRFIRPASTVICCA 363
                    ..|:| |..|..|    :|.:..:.||       |......::|            .
Zfish   266 PRLVAELWGSKVSQVTCGRHHTLVLVALTNRIYSFGCGMQGQLGNGEQVKQS------------V 318

  Fly   364 GAPTLMHIEPRDEF----------GNSCLFDQNQSDEALQGYQVAIYDLHGVPVEKLQHAIVFAY 418
            ..|.|:..:...||          .:..||.:|..:|:.:            |...:...|:...
Zfish   319 PLPVLLPTDCNCEFTMEKIIAGEKHSFALFFKNPGNESTK------------PKSSMNGGILTLN 371

  Fly   419 DKVNSRVSVTALFPEPT-------------CLRAVISYRDQQLPNGDFDIIVLSSSDTTLVHKNI 470
            |::..| .|:..:|.||             ||..  |:....|...|||::..|.|..|...|.|
Zfish   372 DRMIDR-WVSGSYPWPTVKKEIKKVFSSAVCLNG--SFLKPSLDEQDFDLVGKSFSKLTDNEKVI 433

  Fly   471 ASRKHNICYEAKLLSIFGVSKNKPRKVLCYVGPK---QNSLIFQVTIKEMI-------------- 518
            :.                |.|...:.:|..:.||   :.||...:.:.|:|
Zfish   434 SE----------------VVKVIQQTLLPSLNPKPAHEESLRLYLLLPELIKGLEQYQRSELNKA 482

  Fly   519 -------------------------------LKFIPKRIA------------------------- 527
                                           :|...|..|
Zfish   483 LASKILQLNSAAREMLEMFWSKLPDDWLKSLVKLFHKESADLIDYMSVCAMDSDLKHLQNLLRIL 547

  Fly   528 --TFRLCPSTK---------FHFLPQLVSQLHGPVFIIDDGA--QPKIELA--SKDRNIIAATFT 577
              .:::|.||.         .:.:..|::.|..   .|||.|  .|.::..  .|.|:....|..
Zfish   548 QMAYKVCCSTHRDITISDFIIYEISDLLNALQA---TIDDLADWDPFVDYVYMMKLRDYFIKTLE 609

  Fly   578 HFLLKNIGGSETFKDKQDFFYH-EVRKF---------HASYYHEKMALKVQREKILESSMKAVK- 631
              :|........:..|:..|.| |::..         :|::    ..|.:.||.:|..::|.::
Zfish   610 --ILVKFPFVADYASKRGIFNHLEIKMIRRSSNRFLGNATF----NVLHINRESLLMDTLKYLRQ 668

  Fly   632 ---GFSVSDWCGNFEVTFQGEQGIDWGGLRREWFELVCSALFDARGGLFCTFHDKHQALVHPNPT 693
               .||...     .|.|.||.|||..||..|:|.|:..:...         .||....|||:..
Zfish   669 NTHSFSHLS-----RVAFIGEDGIDMRGLSAEFFSLISKSFLK---------WDKKILEVHPSSL 719

  Fly   694 ---RPAHLK-LKHFEFAGKMVGKCLFESALGGTYRQLVRARFSRSFLAQLIGLRVHYKYFEQDDP 754
               .|.|.: .|:|.:.|.:.|..|:.       |..:...|..:...:|:..:......|:..|
Zfish   720 VWFNPHHTRGNKNFYYLGVICGMALYN-------RHHINIDFPLALFKKLLQQKPSLDDLEELSP 777

  Fly   755 DLYLSKIKYILDTDLDATDTLELYFVEEMYDSSSGQLSKTIELIPNGAKTRVTNATKNQYLDALA 819
             :....:|.:|..|.:..|.|.|.|.           .|..||:|||::.:|....:.:|:|...
Zfish   778 -VEARSLKNLLKEDEEVVDLLFLDFT-----------VKGHELVPNGSQIQVNKVNRQKYVDLYV 830

  Fly   820 QQRLCNNVKDEVDSFLKGLNSIIPDNLLSIFDENELELLMCGTGEYSISDFKAHHIANGNSAEFR 884
            ......:||.:.:.|.:|.:...|.:..::|...||:.|:.|:.:|:..:|:......|.||. .
Zfish   831 DFVFNKSVKTQFEQFTRGFSKGCPLDAWTMFHPEELQELLHGSPQYNWKEFQQSASYEGCSAS-D 894

  Fly   885 RVLAWFWAGVSNFSQTEMARLLQFTTGCSQLPPGGFQELNPQFQITAAP-TFGNLPTAHTCFNQL 948
            .::..||......|:....:.|.|..|..::|.|||.:...:......| ...:||.|.|||.:|
Zfish   895 ELIKNFWTVFFELSEEHKKKFLMFLYGTERVPAGGFSKRRIKISTRDCPDPDDHLPKAQTCFGRL 959

  Fly   949 CLPDYESYEQFEKSLLLAISEGSEGFGM 976
            .||.|.........|..||:. .|.||:
Zfish   960 VLPKYTDINTLRNKLTHAINV-CEVFGL 986

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4238	NP_001259896.1	IG_FLMN	238..336	CDD:214720	24/132 (18%)
		Filamin	238..336	CDD:279024	24/132 (18%)
		HECTc	615..975	CDD:238033	92/368 (25%)
		HECTc	642..974	CDD:214523	85/336 (25%)
herc5.2	XP_005160175.1	RCC1_2	120..149	CDD:290274	6/24 (25%)
		RCC1	136..186	CDD:278826	17/76 (22%)
		RCC1	189..238	CDD:278826	15/80 (19%)
		RCC1	242..290	CDD:278826	8/47 (17%)
		RCC1	296..347	CDD:278826	8/62 (13%)
		HECTc	649..985	CDD:294058	92/370 (25%)
		HECTc	678..984	CDD:214523	85/335 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900