Protein Alignment CG4238 and Hectd3

DIOPT Version :9

• Sequence 1: NP_001259896.1
• Gene: CG4238 / 33377
• FlyBaseID: FBgn0031384
• Length: 977
• Species: Drosophila melanogaster
• Sequence 2: NP_780453.1
• Gene: Hectd3 / 76608
• MGIID: 1923858
• Length: 861
• Species: Mus musculus
• Alignment Length: 825
• Identity: 165/825 - (20%)
• Similarity: 293/825 - (35%)
• Gaps: 241/825 - (29%)

  Fly   326 IGASHIAGSPFLRSFLPGAIDARRSRFIRPASTVICCA-GAPTLMHIEPRDEFGNSCLFDQN--- 386
            :||:...||..||: ...:|:.||...:|.....:|.. |....:..|...|..:.|..|:.
Mouse    78 VGAAPGTGSGPLRA-ARDSIELRRGACVRTTGEELCNGHGLWVKLTKEQLAEHLSDCSLDEGWLL 141

  Fly   387 --------------QSDEALQGYQVAIYDLHGV---PVEKLQHAIVFAYD-KVNSRVSVTALFPE 433
                          .:.:.||..|    .|.||   ||.:.:..:...|. ::.||......:.|
Mouse   142 VCRPAEGGARLVPIDTPDHLQRQQ----QLFGVDYRPVLRWEQVVDLTYSHRLGSRPQPAEAYTE 202

  Fly   434 ---------PT----CLRAVISY-------RDQQLPN--------------GDFDIIVLSSSDTT 464
                     ||    |...:|.:       .|:.|.:              .:|::..|:.|:..
Mouse   203 AIQRLLYVPPTWTYECDEDLIHFLYDHLGKEDENLGSVKQYVESIDVSSYTEEFNVSCLTDSNAD 267

  Fly   465 LVHKNIASR---------KHNICYEAKLLSIFGVSKN-KPRKVLCYVGPKQN-----------SL 508
            ...::..|:         |.....:..||::.....| .|::|:.|.|...|           :|
Mouse   268 TYWESDGSQCQHWVRLTMKKGTIVKKLLLTVDTTDDNFMPKRVVVYGGEGDNLKKLSDVNIDETL 332

  Fly   509 IFQVTIKEMILKFIPKRIATFRLCP-----------STKFHFLPQ----LVSQLHGPVFIID--- 555
            |..|.:.|.:...:|  |...|:..           ..|.....|    |.:.|..|..::.
Mouse   333 IGDVCVLEDMTVHLP--IIEIRIVECRDDGIDVRLRGVKIKSSRQRELGLNADLFQPASLVRYPR 395

  Fly   556 -DGAQPKI-----ELASKDRNIIAATFTHFLL---KNIGGSETFKDKQDFFYHEVRKFHASYYHE 611
             :|..|::     .|..:...|:.:...|.:.   ..:|   ||.:     ..:|::|
Mouse   396 LEGTDPEVLYRRAVLLQRFIKILDSVLHHLVPAWDHTLG---TFSE-----IKQVKQF------- 445

  Fly   612 KMALKVQREKI----LESSMKAVKGF------------------SVSDWCGN--FEVTFQG---- 648
             :.|..||..:    |..|..:...|                  |....|.|  |...::|
Mouse   446 -LLLSRQRPSLVAQCLRDSESSKPSFMPRLYINRRLAMEHRACPSRDPACKNAVFTQVYEGLKPS 509

  Fly   649 ---EQGID--WGGLRREWFE--LVCSALFDARGGLFCTFHDKHQALVH----------------- 689
               |:.:|  |.....:|:|  .:...:.|..||...:..|..:.|..
Mouse   510 DKYEKPLDYRWPMRYDQWWECKFIAEGIIDQGGGFRDSLADMSEELCPSSADTPVPLPFFVRTAN 574

  Fly   690 -------------PNPTRPAHLKLKHFEFAGKMVGKCLFESALGGTYRQLVRARFSRSFLA---- 737
                         |||:.....|   :|:.|:::|     :||.|           :.||.
Mouse   575 QGNGTGEARDMYVPNPSCRDFAK---YEWIGQLMG-----AALRG-----------KEFLVLALP 620

  Fly   738 -----QLIGLRVHYKYFEQDDP--DLYLSKIKYILDTDLDATDTLELYFVEEMYDSSSGQLSKTI 795
                 ||.|..|.:   .:|.|  |..|.|:..::: .:| .:|.|..|.:|:..::.....:.:
Mouse   621 GFVWKQLSGEEVSW---SKDFPAVDSVLVKLLEVME-GVD-KETFEFKFGKELTFTTVLSDQQVV 680

  Fly   796 ELIPNGAKTRVTNATKNQYLDALAQQRLCNNVKDEVDSFLKGLNSIIPDNLLSIFDENELELLMC 860
            ||||.|....|....:::::..:.:.|| ...|::|.:...||..::|..:|.:....|||..:|
Mouse   681 ELIPGGTGIVVEYEDRSRFIQLVRKARL-EESKEQVAAMQAGLLKVVPQAVLDLLTWQELEKKVC 744

  Fly   861 GTGEYSISDF-KAHHIANGNSAEFRRVLAWFWAGVSNFSQTEMARLLQFTTGCSQLPPGGFQELN 924
            |..|.::... |.....:...::.|  :.:||..::||:..:.:|.|:|.||.|:||...:  :.
Mouse   745 GDPEVTVDALRKLTRFEDFEPSDTR--VQYFWEALNNFTNEDRSRFLRFVTGRSRLPARIY--IY 805

  Fly   925 PQ---FQITAAPTFGNLPTAHTCFNQLCLPDYESYEQFEKSLLLA 966
            |.   ::.|.|     ||.:.||.:.|.||.|.|.:..|:.|..|
Mouse   806 PDKLGYETTDA-----LPESSTCSSTLFLPHYASAKVCEEKLRYA 845

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4238	NP_001259896.1	IG_FLMN	238..336	CDD:214720	4/9 (44%)
		Filamin	238..336	CDD:279024	4/9 (44%)
		HECTc	615..975	CDD:238033	96/432 (22%)
		HECTc	642..974	CDD:214523	87/381 (23%)
Hectd3	NP_780453.1	APC10-HECTD3	238..371	CDD:176487	21/134 (16%)
		HECTc	528..849	CDD:214523	81/352 (23%)
		HECT	586..845	CDD:279026	74/292 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900