DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4238 and Herc3

DIOPT Version :9

Sequence 1:	NP_001259896.1	Gene:	CG4238 / 33377	FlyBaseID:	FBgn0031384	Length:	977	Species:	Drosophila melanogaster
Sequence 2:	NP_001348895.1	Gene:	Herc3 / 73998	MGIID:	1921248	Length:	1050	Species:	Mus musculus

Alignment Length:	369	Identity:	89/369 - (24%)
Similarity:	158/369 - (42%)	Gaps:	26/369 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   613 MALKVQREKILESSMKAVKGFSVSDWCGNFEVTFQGEQGIDWGGLRREWFELVCSALFDARGGLF 677
            :.|.|:|..::..:::.:...|..|.....:|.|.||:|:|.||:.:|:|.|:...|.:...|:|
Mouse   702 LVLHVRRNHLVGDALRELSIHSDIDLKKPLKVIFDGEEGVDAGGVTKEFFLLLLKELLNPIYGMF 766

  Fly   678 CTFHDKHQALVHPNPTRPAHLKLKHFEFAGKMVGKCLFESALGGTYRQLVRARFSRSFLAQLIGL 742
            ..:.|.:  |:..:.|  ..::...|...|...|..::.|.       :|...|..:...:|:.:
Mouse   767 TYYQDSN--LLWFSDT--CFVEHNWFHLIGITCGLAIYNST-------VVDLHFPLALYKKLLNV 820

  Fly   743 RVHYKYFEQDDPDLYLSKIKYILD---TDLDATDTLELYFVEEMYDSSSGQLSKTIELIPNGAKT 804
            :...:..::..|....| ::.:||   .|::.|..|......|.|    |.:.:. :|||.|.:.
Mouse   821 KPSLEDLKELSPTEGRS-LQELLDYPGEDIEETFCLNFTVCRESY----GVIEQK-KLIPGGDRV 879

  Fly   805 RVTNATKNQYLDALAQQRLCNNVKDEVDSFLKGLNSIIPDNLLSIFDENELELLMCGTGEYSISD 869
            .|....:.:::||........:|.:...:|..|...:....:|.:|...||..:|.|...|...:
Mouse   880 AVCKDNRQEFVDAYVNYIFQISVHEWYTAFSSGFLKVCGGKVLELFQPAELRAMMVGNSNYDWEE 944

  Fly   870 FKAHHIANGNSAEFRRVLAWFWAGVSNFSQTEMARLLQFTTGCSQLPPGGFQELNPQFQITAAPT 934
            .:...:..|:.:.....:..||.....|...:..:.|.|.||..::|..|...|....|.||.
Mouse   945 LEETAVYRGDYSSTHPTVKLFWETFHEFPLEKKKKFLLFLTGSDRIPIYGMASLQIIIQSTAT-- 1007

  Fly   935 FGN--LPTAHTCFNQLCLPDYESYEQFEKSLLLAISEGSEGFGM 976
             |.  ||.||||:|.|.||.|.|.|..:..|..|: :..|||.:
Mouse  1008 -GEEYLPVAHTCYNLLDLPKYSSKEIMKARLTQAL-DNYEGFSL 1049

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4238	NP_001259896.1	IG_FLMN	238..336	CDD:214720
		Filamin	238..336	CDD:279024
		HECTc	615..975	CDD:238033	88/364 (24%)
		HECTc	642..974	CDD:214523	82/336 (24%)
Herc3	NP_001348895.1	ATS1	2..331	CDD:227511
		RCC1	313..377	CDD:366085
		HECTc	702..1048	CDD:238033	88/366 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900