DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4238 and hace1

DIOPT Version :9

Sequence 1:	NP_001259896.1	Gene:	CG4238 / 33377	FlyBaseID:	FBgn0031384	Length:	977	Species:	Drosophila melanogaster
Sequence 2:	XP_012818577.2	Gene:	hace1 / 734146	XenbaseID:	XB-GENE-5757512	Length:	1012	Species:	Xenopus tropicalis

Alignment Length:	880	Identity:	208/880 - (23%)
Similarity:	352/880 - (40%)	Gaps:	206/880 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   222 EARHSLLQYVT--------GKYLLPANCK------------VQWDWKDPASVGGT-MCFVVRFFQ 265
            |..|.|:|:||        |:..|...|:            ...|...|...|.| :.|.....|
Frog   213 ELLHDLVQHVTNVDVEDAMGQTALHVACQNGHKTTVLCLLDSGADINRPNVSGATPLYFACSHGQ 277

  Fly   266 RN--------GQPY--------PI-----------CDTDHFFVEVTEGTRKVVTISELGSSTDPN 303
            |:        |..|        |:           ||     :.:....|...|:.::..:.|..
Frog   278 RDTAQILLLRGAKYLPDKNGVTPLDLCVQGGYGETCD-----ILIQHHPRLFQTLIQMTQNEDLR 337

  Fly   304 NANIAKV--KFTVRTAGQYKISVLIGASHIA---GSPFLRSFLPGAIDARRSRFIRPASTVICCA 363
            ...:.:|  ..:.::..|| :.:|.|.:.:|   |...|.  :..:.:|:....:| ...:.|
Frog   338 ENTLRQVLEHLSQQSEVQY-LKILTGLAEVATTNGHKLLS--ISSSYEAQMKSLLR-IVRIFC-- 396

  Fly   364 GAPTLMHI------EPRDEFGNSCLFDQNQSDEALQGYQVA-IYDL-------------HGV--- 405
                  |:      .|.:  ||...::.|::... |.::|. :||:             |.:
Frog   397 ------HVFRIGPSSPNN--GNDMGYNGNKTPRN-QVFKVRNVYDVFRKINIKEMNLPNHTLIYQ 452

  Fly   406 ------PVEKLQHA-----IVFAYDKVNSRVSVTALFPEPTCLRAVISYRDQQLPNGDFDIIVLS 459
                  |:|.|.|:     ::.|.:...::...:.:        |.|..:..||...|..:...|
Frog   453 ATSEQDPLELLWHSLDEWLVLIATELTKNKRDSSNI--------ACILLKQNQLDQQDISLAHQS 509

  Fly   460 SSDTTLVHKNIASRKHNICYEAKLLSIFGVSKNKPRKVLCYVGPKQNSLIFQVTIKEMILKFIPK 524
            :...:..:.:::|......:|:                 |....||..:.....:..|....:..
Frog   510 AIGESGSYDHLSSSTRAEDFES-----------------CSAAGKQEPVADGQDVISMTANRLSA 557

  Fly   525 RIATFRLCPSTKFHFLPQLVSQLHGPVFIIDDGAQPKIELASKDRNIIAATFT----------HF 579
            .|..|.:|.|.:   :||   .:..|.|         ||...|..:::....|          ||
Frog   558 VIQAFYMCCSCQ---MPQ---GMTSPRF---------IEFVCKHDDVLKCFVTRNPKIIFDHFHF 607

  Fly   580 LLK---------NIGGSETFKDKQDFFYHEV-------RKFHASYYHEKMALKVQREKILESSMK 628
            ||:         :|..::.||::.::||..:       ...|.. .:|...|.|.|:.|..||.:
Frog   608 LLECPELMSRFMHIIKAQPFKERCEWFYEHLLAGQPDSDMVHRP-VNENDILLVHRDSIFRSSCE 671

  Fly   629 AVKGFSVSDWCGNFEVTFQGEQGIDWGGLRREWFELVCSALFDARGGLF------CTFHDKHQAL 687
            .|...:.........|.|.||:|:. .|:.||||:::.|.:.:....||      .||.....:.
Frog   672 VVFKSNCEKLKQGIAVRFHGEEGMG-QGVVREWFDILSSEIINPDYALFTQSADGTTFQPNSNSS 735

  Fly   688 VHPNPTRPAHLKLKHFEFAGKMVGKCLFESALGGTYRQLVRARFSRSFLAQLIGLRVHYKYFEQD 752
            |:|:       .|.:|.|||:::|..|:       :||||...|:|||...::|:.|:|:.....
Frog   736 VNPD-------HLNYFRFAGEILGLALY-------HRQLVNIYFTRSFYKHILGIPVNYQDVASI 786

  Fly   753 DPDLYLSKIKYILDTDLDATDTLELYFVEEMYDSSSGQLSKTIELIPNGAKTRVTNATKNQYLDA 817
            ||: |...:::|||.|:.... |||.|..|  ....|.:.: :.|.|.||...||...|.:|:..
Frog   787 DPE-YAKNLQWILDNDISDLG-LELTFSVE--TDVFGAMEE-VPLKPGGASILVTQENKAEYVQL 846

  Fly   818 LAQQRLCNNVKDEVDSFLKGLNSIIPDNLLSIFDENELELLMCGTGEYSISDFKAHHIANGNSAE 882
            :.:.|:...::.:::.||:|.:..||.:|:.:|||.|||||:.|..|..::|:..:.........
Frog   847 VTELRMTRAIQPQINGFLQGFHMFIPPSLIQLFDEYELELLLSGMPEIDVNDWMKNTEYTSGYER 911

  Fly   883 FRRVLAWFWAGVSNFSQTEMARLLQFTTGCSQLPPGGFQELN-----PQFQITA-APTFGNLPTA 941
            ..:|:.|||..|...:|.|...||||.||.|::|.|||..:.     ..|.|.| |.|...|||:
Frog   912 DDQVIQWFWEVVQELTQEERVLLLQFVTGSSRVPHGGFAYIMGGSGLQNFTIAAVAYTPNLLPTS 976

  Fly   942 HTCFNQLCLPDYESYEQFEKSLLLAISEGSEGFGM 976
            .||.|.|.||:|.|.|..:..||:|:..||.|:.|
Frog   977 STCINMLKLPEYPSKEILKDRLLVALHCGSYGYTM 1011

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4238	NP_001259896.1	IG_FLMN	238..336	CDD:214720	23/142 (16%)
		Filamin	238..336	CDD:279024	23/142 (16%)
		HECTc	615..975	CDD:238033	122/371 (33%)
		HECTc	642..974	CDD:214523	114/343 (33%)
hace1	XP_012818577.2	PLN03192	<19..289	CDD:215625	16/75 (21%)
		ANK repeat	134..163	CDD:293786
		ANKYR	<160..288	CDD:223738	16/74 (22%)
		ANK repeat	165..196	CDD:293786
		ANK repeat	198..229	CDD:293786	6/15 (40%)
		ANK repeat	231..262	CDD:293786	4/30 (13%)
		ANK repeat	264..289	CDD:293786	5/24 (21%)
		HECTc	657..1006	CDD:238033	119/368 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D140374at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920