Protein Alignment CG4238 and UBE3A

DIOPT Version :9

• Sequence 1: NP_001259896.1
• Gene: CG4238 / 33377
• FlyBaseID: FBgn0031384
• Length: 977
• Species: Drosophila melanogaster
• Sequence 2: NP_000453.2
• Gene: UBE3A / 7337
• HGNCID: 12496
• Length: 875
• Species: Homo sapiens
• Alignment Length: 584
• Identity: 140/584 - (23%)
• Similarity: 258/584 - (44%)
• Gaps: 105/584 - (17%)

  Fly   440 VIS--YRDQQLPNGDFDIIVLSSSDTTLVHKNI----ASRKHN---------ICYEAKLLSIFGV 489
            |||  :..:.|.|.|..|:..|.....:.:.|:    ....||         ...|..|..:.|.
Human   351 VISNEFNSRNLVNDDDAIVAASKCLKMVYYANVVGGEVDTNHNEEDDEEPIPESSELTLQELLGE 415

  Fly   490 SKNKPRKVLCYVGPKQNSLIFQVTIKEMILKFIPKRIATFRLCPSTKFHFLPQLVSQLHGPVFII 554
            .:...:      ||:.:.|..::.:|.:..:   |.:..|.           :.:::....|..:
Human   416 ERRNKK------GPRVDPLETELGVKTLDCR---KPLIPFE-----------EFINEPLNEVLEM 460

  Fly   555 D-DGAQPKIELASKDRNIIAATFTHFLLKNIGGSETFKDKQDFFYHEVRKFHASY-------YHE 611
            | |....|:|..:|...:......:.:.||:|   .:.|.:...|.| |:....|       .:.
Human   461 DKDYTFFKVETENKFSFMTCPFILNAVTKNLG---LYYDNRIRMYSE-RRITVLYSLVQGQQLNP 521

  Fly   612 KMALKVQREKILESSMKAVKGFSV---SDWCGNFEVTFQGEQGIDWGGLRREWFELVCSALFDAR 673
            .:.|||:|:.|::.::..::..::   :|......|.|:||||:|.||:.:|:|:||...:|:..
Human   522 YLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPD 586

  Fly   674 GGLFCTFHDKHQALVHPNPTRPAHLKLKHFEFAGK------MVGKCLFESALGGTYRQLVRARFS 732
            .|:|.  :|:...|...||:        .||..|:      ::|..::.:.:...:..:|..|
Human   587 IGMFT--YDESTKLFWFNPS--------SFETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYR-- 639

  Fly   733 RSFLAQLIGLRVHYKYFEQDDPDLYLSKIKYILDTDLDATDTLELYFVEEMYDSSSGQLSKT--- 794
                 :|:|.:..::......|.||.| :|.:|:.:.:..|.:.:.|          |:|:|
Human   640 -----KLMGKKGTFRDLGDSHPVLYQS-LKDLLEYEGNVEDDMMITF----------QISQTDLF 688

  Fly   795 -----IELIPNGAKTRVTNATKNQYLDALAQQRLCNNVKDEVDSFLKGLNSIIPDNLLS-IFDEN 853
                 .:|..||.|..:||..:.::::..:...|..:|:.:..:|.:|.:.:..::.|. :|...
Human   689 GNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPE 753

  Fly   854 ELELLMCGTGEYSISDFKAHHIANGNSAEFRR---VLAWFWAGVSNFSQTEMARLLQFTTGCSQL 915
            |:|||:||:...   ||:|..........:.|   ::..||..|.:|:..:....||||||..:.
Human   754 EIELLICGSRNL---DFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRA 815

  Fly   916 PPGGFQELNPQFQITA--APTFGNLPTAHTCFNQLCLPDYESYEQFEKSLLLAISEGSEGFGMV 977
            |.||..:|.   .|.|  .|....|||:|||||.|.||:|.|.|:.::.||.||:. ::||||:
Human   816 PVGGLGKLK---MIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITY-AKGFGML 875

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4238	NP_001259896.1	IG_FLMN	238..336	CDD:214720
		Filamin	238..336	CDD:279024
		HECTc	615..975	CDD:238033	103/382 (27%)
		HECTc	642..974	CDD:214523	96/351 (27%)
UBE3A	NP_000453.2	AZUL	29..83	CDD:406862
		HECTc	523..873	CDD:238033	103/384 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910