Protein Alignment CG4238 and Ubr5

DIOPT Version :9

• Sequence 1: NP_001259896.1
• Gene: CG4238 / 33377
• FlyBaseID: FBgn0031384
• Length: 977
• Species: Drosophila melanogaster
• Sequence 2: XP_006520242.1
• Gene: Ubr5 / 70790
• MGIID: 1918040
• Length: 2800
• Species: Mus musculus
• Alignment Length: 1179
• Identity: 220/1179 - (18%)
• Similarity: 366/1179 - (31%)
• Gaps: 472/1179 - (40%)

  Fly    59 KTFPT----------LKVKLCFGESMGISSLSSCGDPERLPELPPLDEQRLQRAALHLQQKLILR 113
            |..||          .:.:|.:|     |:|:|.|||.. |..|           ||..|....|
Mouse  1834 KLIPTWNWMVSVMDSTEAQLRYG-----SALASAGDPGH-PNHP-----------LHASQNSARR 1881

  Fly   114 EWLKDHRLQHHYQRLLAVEVASLEDVYWLEDSRASKILGKDWQLWSGARQNLPTSKAQLDALKAQ 178
            |            |:.|.|.|||..   ||..|.:.:|        .|||.:.:::.  |.|...
Mouse  1882 E------------RMTAREEASLRT---LEGRRRATLL--------SARQGMMSARG--DFLNYA 1921

  Fly   179 LWSTVVKSSQHQDAWTWGGML-------VVSVSVAGLVTLAAMTQ------PSLAPEARHSLLQY 230
            |......:.:|.|...   :|       |..|..|.:..:.||.|      |.|..:....||:.
Mouse  1922 LSLMRSHNDEHSDVLP---VLDVCSLKHVAYVFQALIYWIKAMNQQTTLDTPQLERKRTRELLEL 1983

  Fly   231 VTGKYLLPANCKVQWDWKDPASVGGTMCFVVRFFQRNGQPYPICDTDHFFVEVTEGTRKVVTISE 295
            .....                                       |::|   |..:.|.:..|:::
Mouse  1984 GIDNE---------------------------------------DSEH---ENDDDTSQSATLND 2006

  Fly   296 LGSSTDPNNANIAKVKFTVRTAGQYKISVLIGASHIAGSPFLR-----SFLPGAIDARRSRFIRP 355
            ....:.|...                     |.:|    ||.|     :|| |.|..  :.|..|
Mouse  2007 KDDDSLPAET---------------------GQNH----PFFRRSDSMTFL-GCIPP--NPFEVP 2043

  Fly   356 ASTVICCAGAPTLMHIEPRDEFGNSCLFDQNQSDEALQGYQVAIYDLHGVPVEKLQHAIVFAYDK 420
            .:..|..|..|.|:....|.|                        ||.|.|.:.|..:      .
Mouse  2044 LAEAIPLADQPHLLQPNARKE------------------------DLFGRPSQGLYSS------S 2078

  Fly   421 VNSRVSVTALFPEPTC-------------LRAVISYRDQQLPNGDFDIIVLSSSDTTL---VHKN 469
            ..|...:..:..:..|             |:.|::.:::|...|:...::...:|::.   ...:
Mouse  2079 AGSGKCIVEVTMDRNCLEVLPTKMSYAANLKNVMNMQNRQKKEGEEQSLLAEEADSSKPGPSAPD 2143

  Fly   470 IASRKHNICYEAKLLSIFGVSKNKPRKVLCYVGPKQNSLIFQVTIKEMILKFIPKRIATFRLCPS 534
            :|::     .::.||:..|:::::        ||...|...|.:...|::.. ...:..:||.
Mouse  2144 VAAQ-----LKSSLLAEIGLTESE--------GPPLTSFRPQCSFMGMVISH-DMLLGRWRLS-- 2192

  Fly   535 TKFHFLPQLVSQLHGPVFIIDDGAQPKIELASKDRNIIAATFTHFLLKNIGGSETFKDKQDFFYH 599
                      .:|.|.||:.|.||:|                 ..:|..:||   |:.|:..|..
Mouse  2193 ----------LELFGRVFMEDVGAEP-----------------GSILTELGG---FEVKESKFRR 2227

  Fly   600 EVRKFHASYYHE-KMALKVQREK--ILESSMKAVKGFSVSDWCG-------NFEVTFQGEQGIDW 654
            |:.|.......: .:.:||.|::  :::.:|:.:.. .....|.       ..:|||:.|.| :.
Mouse  2228 EMEKLRNQQSRDLSLEVKVDRDRDLLIQQTMRQLNN-HFGRRCATTPMAVHRVKVTFKDEPG-EG 2290

  Fly   655 GGLRREWFELVCSALFD----------------------------------------------AR 673
            .|:.|.::..:..|...                                              .|
Mouse  2291 SGVARSFYTAIAQAFLSNEKLPNLDCIQNANKGTHTSLMQRLRNRGERDREREREREMRRSSGLR 2355

  Fly   674 GG--------------------------------------------------------------- 675
            .|
Mouse  2356 AGSRRDRDRDFRRQLSIDTRPFRPASEGNPSDDPDPLPAHRQALGERLYPRVQAMQPAFASKITG 2420

  Fly   676 -----------LFCTFHDKHQALVH---------------------------------------- 689
                       |.....|..:|.|.
Mouse  2421 MLLELSPAQLLLLLASEDSLRARVDEAMELIIAHGRENGADSILDLGLLDSSEKVQENRKRHGSS 2485

  Fly   690 -------------------------------PNPTRPAHLKLKHFEFAGKMVGKCLFESALGGTY 723
                                           |.|.:....:|..|...|:::|.||.::
Mouse  2486 RSVVDMDLEDTDDGDDNAPLFYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCLLQN------ 2544

  Fly   724 RQLVRARFSRSFLAQLIGLRVHYKYFEQDDPDLYLSKIKYIL---DTDLDAT-DTLELYF-VEEM 783
             :|.....:|..:..|:|.:|::..|...||.:|.|..:.||   .:|.||. ..::|.| ::..
Mouse  2545 -ELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDLC 2608

  Fly   784 YDSSSGQLSKTIELIPNGAKTRVTNATKNQYLDALAQQRLCNNVKDEVDSFLKGLNSIIPDNLLS 848
            .:...||    :||||||....||.....:|:...|:.|:....:..:.:..|||..::|.|.|.
Mouse  2609 KEEGGGQ----VELIPNGVNIPVTPQNVYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLE 2669

  Fly   849 IFDENELELLMCGTGEYSIS---DFKAHHIANGNSAE----FRRVLAWFWAGVSNFSQTEMARLL 906
            .....:..||:.|.||.::.   .|.:.:..:|.:||    |:|   |||:.|...|.||...|:
Mouse  2670 DLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLLQFKR---WFWSIVEKMSMTERQDLV 2731

  Fly   907 QFTTGCSQLPPG--GFQELNPQFQITAAPTFG-NLPTAHTCFNQLCLPDYESYEQFEKSLLLAIS 968
            .|.|....||..  |||   |...||..|... :||||:||.::|.:|.|.|.:..::.|||||.
Mouse  2732 YFWTSSPSLPASEEGFQ---PMPSITIRPPDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIK 2793

  Fly   969 EGSEGFGMV 977
              ::.||.|
Mouse  2794 --TKNFGFV 2800

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4238	NP_001259896.1	IG_FLMN	238..336	CDD:214720	8/97 (8%)
		Filamin	238..336	CDD:279024	8/97 (8%)
		HECTc	615..975	CDD:238033	108/574 (19%)
		HECTc	642..974	CDD:214523	103/537 (19%)
Ubr5	XP_006520242.1	CUE_UBR5	184..230	CDD:270606
		ZnF_UBR1	1177..1244	CDD:197698
		PolyA	2391..2454	CDD:197769	4/62 (6%)
		HECTc	2469..2797	CDD:214523	89/346 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900