Protein Alignment CG4238 and Arel1

DIOPT Version :9

• Sequence 1: NP_001259896.1
• Gene: CG4238 / 33377
• FlyBaseID: FBgn0031384
• Length: 977
• Species: Drosophila melanogaster
• Sequence 2: NP_001351118.1
• Gene: Arel1 / 68497
• MGIID: 1915747
• Length: 823
• Species: Mus musculus
• Alignment Length: 845
• Identity: 409/845 - (48%)
• Similarity: 529/845 - (62%)
• Gaps: 91/845 - (10%)

  Fly   197 GMLVVSV-----SVAGLVTLAAMTQPSLAPEAR-----HSLLQYVTGKYLLPANCKVQWDWKDPA 251
            |.::|||     ::..|..|||.....|..|.|     .::..||.|.||.|.:|||.||||||.
Mouse     6 GGIIVSVVAFFFTIKFLFELAARVVSFLQNEDRERRGDRTIYDYVRGNYLDPRSCKVSWDWKDPY 70

  Fly   252 SVGGTMCFVVRFFQRNGQPYPICDTDHFFVEVTEGTRKVVTISELGSSTD---------PNNANI 307
            .||.:|.|.|..|.:||||:|.    |..|    |.|  |.||.:..:.|         ..|:|:
Mouse    71 EVGHSMAFRVHLFYKNGQPFPA----HRPV----GLR--VHISHVELAVDIPVTQEVLQEPNSNV 125

  Fly   308 AKVKFTVRTAGQYKISVLIGASHIAGSPFLRSFLPGAIDARRSRFIRPASTVICCAGAPTLMHIE 372
            .||.||||.||:|:|:|.:|..::|.||:.:.|.||.:...:::.:...||::...|.|..:.|.
Mouse   126 VKVAFTVRKAGRYEITVKLGGLNVAYSPYYKIFQPGMVVPSKTKIVCHFSTLVLTCGQPHTLQIV 190

  Fly   373 PRDEFGNSCLFDQNQSDEALQGYQVAIYDLHGVPVEKLQHAIVFAYDKVNSRVSVTALFPEPT-- 435
            ||||:.|......:..||  ..|.:||::|.  |.|:..:.:.|. ..|.|......:|...|
Mouse   191 PRDEYDNPTNNSMSLRDE--HSYSLAIHELG--PQEEENNEVSFE-KSVTSNRQTCQVFLRLTLH 250

  Fly   436 ---CLRAVISYRDQQLPNGDFDIIVLSSSDTTLVHKNIASRKHNICYEAKLLSIFGVSK------ 491
               |..|.|||::|.:.||:|||||||.::..:|.:|:::...:|.:||.|.:....:.
Mouse   251 SRGCFHACISYQNQPINNGEFDIIVLSENEKNIVERNVSTSGVSIYFEAYLYNANNCTSTPWHLP 315

  Fly   492 --------------------------------NKPRKVLCYVGPKQNSLIFQVTIKEMILKFIPK 524
                                            .||:||.|||.|||.|      :||..||.||.
Mouse   316 PMHMSSSQRRPSTAIEEDDEDSPSECHTPEKVKKPKKVYCYVSPKQFS------VKEFYLKIIPW 374

  Fly   525 RIATFRLCPSTKFHFL-PQLVSQLHGPVFIIDDGAQPKIELASKDRNIIAATFTHFLLKNIGGSE 588
            |:.|||:||.|||.:| |..|.:|  ...::|||.||.:||:.|:|||:||||...|.|||||||
Mouse   375 RLYTFRVCPGTKFSYLGPDPVHKL--LTLVVDDGIQPPVELSCKERNILAATFIRSLHKNIGGSE 437

  Fly   589 TFKDKQDFFYHEVRKFHASYYHEKMALKVQREKILESSMKAVKGFSVSDWCGNFEVTFQGEQGID 653
            ||:||.:||..|:|:.|....|.|:.|||.|..:||||:||.:.||:|||..||||.||.|:.:|
Mouse   438 TFQDKVNFFQRELRQVHMKRPHSKVTLKVSRHALLESSLKATRNFSISDWSKNFEVVFQDEEALD 502

  Fly   654 WGGLRREWFELVCSALFDARGGLFCTFHDKHQALVHPNPTRPAHLKLKHFEFAGKMVGKCLFESA 718
            |||.|||||||:|.||||....||..|.|.:||||||||.|||||:||.:||||::|||||:||:
Mouse   503 WGGPRREWFELICKALFDTTSQLFARFTDSNQALVHPNPNRPAHLRLKMYEFAGRLVGKCLYESS 567

  Fly   719 LGGTYRQLVRARFSRSFLAQLIGLRVHYKYFEQDDPDLYLSKIKYILDTDLDATDTLELYFVEEM 783
            |||.|:|||||||:||||||:||||:||||||.|||:.|.||:.:||:.|:   ..:||.|.||.
Mouse   568 LGGAYKQLVRARFTRSFLAQIIGLRMHYKYFETDDPEFYKSKVCFILNNDM---SEMELVFAEEK 629

  Fly   784 YDSSSGQLSKTIELIPNGAKTRVTNATKNQYLDALAQQRLCNNVKDEVDSFLKGLNSIIPDNLLS 848
            | :.||||.|.:||:..||:|.||||.|..||:.|||.||.:.||:||:.||||||.::|:|||:
Mouse   630 Y-NKSGQLDKIVELMTGGAQTPVTNANKIFYLNLLAQYRLASQVKEEVEHFLKGLNELVPENLLA 693

  Fly   849 IFDENELELLMCGTGEYSISDFKAHHIANGNSAEFR-RVLAWFWAGVSNFSQTEMARLLQFTTGC 912
            |||||||||||||||:.::||||||.:..|.|..|| :|:.||||.||:.:|.|:|||||||||.
Mouse   694 IFDENELELLMCGTGDINVSDFKAHAVVVGGSWHFREKVMRWFWAVVSSLTQEELARLLQFTTGS 758

  Fly   913 SQLPPGGFQELNPQFQITAAPTFGNLPTAHTCFNQLCLPDYESYEQFEKSLLLAISEGSEGFGMV 977
            ||||||||..|.|.|||.||||...||||||||||||||.|:|||:..:.|.||||||.|||||:
Mouse   759 SQLPPGGFAALCPSFQIIAAPTHSTLPTAHTCFNQLCLPTYDSYEEVHRMLQLAISEGCEGFGML 823

  Fly   978  977
            Mouse   824  823

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4238	NP_001259896.1	IG_FLMN	238..336	CDD:214720	45/106 (42%)
		Filamin	238..336	CDD:279024	45/106 (42%)
		HECTc	615..975	CDD:238033	233/360 (65%)
		HECTc	642..974	CDD:214523	216/332 (65%)
Arel1	NP_001351118.1	Filamin	56..154	CDD:395505	45/107 (42%)
		Filamin	64..158		42/103 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	315..345		0/29 (0%)
		HECTc	464..821	CDD:238033	233/360 (65%)
		Interaction with SOCS2. /evidence=ECO:0000250|UniProtKB:O15033	483..789		199/309 (64%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847514
Domainoid	1	1.000	414	1.000	Domainoid score	I672
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8885
Inparanoid	1	1.050	735	1.000	Inparanoid score	I602
Isobase	1	0.950	-	0	Normalized mean entropy	S2931
OMA	1	1.010	-	-		QHG49700
OrthoDB	1	1.010	-	-		D140374at33208
OrthoFinder	1	1.000	-	-		FOG0008343
OrthoInspector	1	1.000	-	-		oto94332
orthoMCL	1	0.900	-	-		OOG6_108355
Panther	1	1.100	-	-	LDO	PTHR11254
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4924
SonicParanoid	1	1.000	-	-		X6322
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	16.750