DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG4238 and Herc6

DIOPT Version :9

Sequence 1:NP_001259896.1 Gene:CG4238 / 33377 FlyBaseID:FBgn0031384 Length:977 Species:Drosophila melanogaster
Sequence 2:NP_080268.1 Gene:Herc6 / 67138 MGIID:1914388 Length:1003 Species:Mus musculus


Alignment Length:997 Identity:196/997 - (19%)
Similarity:347/997 - (34%) Gaps:279/997 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   124 HYQRLLAVEVASLEDVY---WLEDSRASKILGKDWQLWSGARQNLPTSKAQLDALKAQLWSTVVK 185
            ||..|     |..||.:   |..:|.....|||:             |::|....|       ||
Mouse   136 HYHSL-----ALSEDGHVFSWGRNSEGQLGLGKN-------------SRSQAIPQK-------VK 175

  Fly   186 SSQHQDAWTWGGMLVVSVSVAGLVTLA-AMTQPSLAPEARHSLLQYVTGKYLLPANCKVQWDWKD 249
            |.:        |:.:..|:..|..:.| ::|..|....:..|      |:..|..| ||:.....
Mouse   176 SLE--------GIPLAQVAAGGTHSFALSLTGTSFGWGSNRS------GQLALSGN-KVKEQIYK 225

  Fly   250 PASVGGTMCFVVRFFQRNGQPYPICDTDHFFVEVTEGTRKVVTISELGSST---DPN-------- 303
            |.|:|......|.:..        |..:|..|...||  :|.|..  |:|:   .|:        
Mouse   226 PHSIGALKNLSVIYIS--------CGYEHTAVLTEEG--QVFTFG--GNSSGQLQPSPRSGQRGP 278

  Fly   304 ------NANIAKVKFT-------VRTAGQYKISVLIGASHIAGSPFLRSFLPGAIDARRSRFIRP 355
                  ...:::::..       |.|.||. :|:..|.||.:.        |...:|       |
Mouse   279 QLIEGIGGRVSQIECASYHTIAYVYTTGQV-VSLGRGPSHTSN--------PTHQEA-------P 327

  Fly   356 A--STVICCAGAPTLMHIEPRDEFGN---SCLFDQNQSDEALQGYQVAIYDLHGVP-VEKLQHAI 414
            |  |.:.|...|..|:.||.:|.|..   :.:..:..|.....|..:.|     :| :.::..::
Mouse   328 AENSDITCLLAAEDLVDIEVKDIFAGAHANFVTTRRVSHTRSTGVSMKI-----LPEIIRINQSL 387

  Fly   415 VFAY-------DKVNSRVSVTALFPEPTCLRAVISYRDQQLPNGDFDIIVLSSSDTTLVHKNIAS 472
            |..:       |:..::..::.:|....||.|....:.....|...|:.:..:.|   |.|.:.:
Mouse   388 VKKWRAANKRKDREGAKREISLIFSSSACLTASFLKKRDAGENNLIDVDLKLARD---VFKKLTT 449

  Fly   473 RKH-----NICYEAKLLSIFGVSKNKPRKVLCYVGPKQNSLIFQVTIKE---------------- 516
            .|.     ..|.|..||           :.|.|..|.|.:|:..:.:.|                
Mouse   450 EKWISSLITTCLEEYLL-----------RDLPYSSPHQEALLVFLLLPECSIMQDPKNWKTLAFE 503

  Fly   517 ---MILKFIPKRIATFRLCPS--------------------------------TKFHFLPQLVSQ 546
               .|.|..|:.:|..|.|.:                                |....|.:::.:
Mouse   504 FAKAIHKMGPQSLAFLRTCWASLEVSSLNILVQMLKKAIISQIQYGVATEQYITNIKVLLEVIKE 568

  Fly   547 LH-------GPVFIID--------DGAQPKIELASKDRNIIAAT----FTHFLLKNIGGSETFKD 592
            :|       ...|||:        |....::.:...|.:...::    |:.||......|:....
Mouse   569 VHKANCQLPESAFIINELSGIFNFDAEAGRMFIRHNDLDCTESSDMVVFSDFLFVFDLPSKIKLM 633

  Fly   593 KQDFFYHEVRKFHASYYHEKMA------LKVQREKILESSMKAVKGFSVSDWCGNFEVTFQGEQG 651
            |.|.|...:.:..|  :.|||:      |||:|..::|.:::.::.....|......|.|..|..
Mouse   634 KCDSFVKLMSEVMA--FPEKMSSPPYLILKVRRSHLVEDTLRQLRQVEDFDLRKQLSVGFINEIR 696

  Fly   652 IDWGGLRREWFELVCSALFDARGGLFCTFHDKHQALVHPN-------PTRPAHLKLKHFEFAGKM 709
            .:.||:..|:|..:...:.|          .|::..::|.       |..|...|..:|.| |.:
Mouse   697 PEAGGVSSEFFHCIFEEMTD----------PKYEMFIYPEKGSSMWFPVNPKFEKSSYFLF-GIL 750

  Fly   710 VGKCL---------FESALGGTYRQLVRARFSRSFLAQLIGLRVHYKYFEQDDPDLYLSK-IKYI 764
            .|..|         |..||   |::|:..:.|...|.:|               .|.|.: ::.:
Mouse   751 CGLSLHNLKVINLPFPLAL---YKKLLNQKPSLEDLKEL---------------SLPLGRNLQEV 797

  Fly   765 LDTDLDATDTLELYFVEEMYDSSSGQLSKTIELIPNGAKTRVTNATKNQYLDALAQQRLCNNVKD 829
            |:.:....:.|.:||  .:|..     .|.::|||:|....|....|..|:..........::|.
Mouse   798 LNCEAGDIEELHMYF--SIYWD-----QKDVDLIPDGISVPVNETNKRDYVSKYVDYIFNISIKT 855

  Fly   830 EVDSFLKGLNSIIPDNLLSIFDENELELLMCGTGEYSISDFKAHHIANGNSAEFR-------RVL 887
            ..:.|.:|...:...:::..|...||...:.|........|:       |:::::       ..:
Mouse   856 IYEEFHRGFYKVCNWDIIRQFQPEELMTAIIGNATCDWKQFE-------NNSKYKDGYDKSHPTI 913

  Fly   888 AWFWAGVSNFSQTEMARLLQFTTGCSQLPPGGFQELNPQFQITAAPTFGNLPTAHTCFNQLCLPD 952
            ..||....:.:..|..:.|.|.|||.:|...|.|.....|:.:...:..:.|.:.||...|.||.
Mouse   914 LLFWKAFHDLTLDEKKKFLLFLTGCDRLHVKGLQNEGIVFRCSETFSEEDNPRSLTCHRMLDLPK 978

  Fly   953 YESYEQFEKSLLLAISEGSEGF 974
            |.|..:.:::|.:||: .|.||
Mouse   979 YSSMRRMKEALQVAIN-NSTGF 999

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG4238NP_001259896.1 IG_FLMN 238..336 CDD:214720 25/121 (21%)
Filamin 238..336 CDD:279024 25/121 (21%)
HECTc 615..975 CDD:238033 82/384 (21%)
HECTc 642..974 CDD:214523 74/355 (21%)
Herc6NP_080268.1 RCC1 1 40..91
RCC1 40..89 CDD:278826
RCC1 2 92..144 4/12 (33%)
RCC1 92..142 CDD:278826 3/10 (30%)
RCC1 145..195 CDD:278826 15/77 (19%)
RCC1 3 146..197 15/78 (19%)
RCC1_2 183..211 CDD:290274 6/33 (18%)
RCC1 4 199..252 14/67 (21%)
RCC1_2 237..266 CDD:290274 10/40 (25%)
RCC1 5 253..303 7/53 (13%)
RCC1 253..300 CDD:278826 7/50 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 261..281 3/19 (16%)
chaperonin_like <570..>652 CDD:295468 15/83 (18%)
HECTc 658..999 CDD:238033 80/384 (21%)
HECTc 682..999 CDD:214523 75/360 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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