DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4238 and nedd4a

DIOPT Version :9

Sequence 1:	NP_001259896.1	Gene:	CG4238 / 33377	FlyBaseID:	FBgn0031384	Length:	977	Species:	Drosophila melanogaster
Sequence 2:	NP_001029358.1	Gene:	nedd4a / 619412	ZFINID:	ZDB-GENE-051005-2	Length:	910	Species:	Danio rerio

Alignment Length:	404	Identity:	131/404 - (32%)
Similarity:	213/404 - (52%)	Gaps:	42/404 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   587 SETFKDKQDFFYHEVRKFHASYYHEKMALKVQREKILESSMKAVKGFSVSD------WCGNFEVT 645
            |..:|.|.::|..:::|  .:....:..|.|:|..:||.|.:.:.....|:      |     |.
Zfish   529 SRDYKQKYEYFRKKLKK--PAEIPNRFELSVRRNAVLEDSYRRILSVKRSELLKARLW-----VE 586

  Fly   646 FQGEQGIDWGGLRREWFELVCSALFDARGGLF-CTFHDKHQALVHPNPTRPAHLKLKHFEFAGKM 709
            |:||:|:|:||:.||||.|:...:|:...||| .:..|.:...::||........|.:|:|.|::
Zfish   587 FEGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRV 651

  Fly   710 VGKCLFESALGGTYRQLVRARFSRSFLAQLIGLRVHYKYFEQDDPDLYLSKIKYILD---TDLDA 771
            .|..::       :.:|:.|.|.|.|...::...:..:..|..|.: |.:.:::||:   ||||.
Zfish   652 AGMAVY-------HGKLLDAFFIRPFYKMMLQKPITLQDMESVDSE-YFNSLRWILENDPTDLDL 708

  Fly   772 TDTLELYFVEEMYDSSSGQLSKTIELIPNGAKTRVTNATKNQYLDALAQQRLCNNVKDEVDSFLK 836
            ..|::    ||::    ||..:. ||.|.||...|.:..|.:|:..:.|.|..:.::.::.:|.:
Zfish   709 RFTID----EELF----GQTHQH-ELKPGGADIVVNDTNKKEYIHLVMQWRFVDRIQRQMTAFKE 764

  Fly   837 GLNSIIPDNLLSIFDENELELLMCGTGEYSISDFKAH-HIANGNSAEFRRVLAWFWAGVSNFSQT 900
            |...:||.:|:.|||||||||||||.|:..::|::.: ...||.:.....:: |||..|......
Zfish   765 GFYELIPQDLIKIFDENELELLMCGLGDVDVNDWRENTKYKNGYNPNHPAII-WFWKTVLLMDAE 828

  Fly   901 EMARLLQFTTGCSQLPPGGFQEL----NPQ-FQITAAPTFGNLPTAHTCFNQLCLPDYESYEQFE 960
            :..|||||.||.|::|..||.||    .|| |.|....|...||.||||||:|.||. ||:|:..
Zfish   829 KRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGTREKLPRAHTCFNRLDLPPXESFEELR 893

  Fly   961 KSLLLAISEGSEGF 974
            :.|.:|| |.::||
Zfish   894 EKLHMAI-ENAQGF 906

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4238	NP_001259896.1	IG_FLMN	238..336	CDD:214720
		Filamin	238..336	CDD:279024
		HECTc	615..975	CDD:238033	126/376 (34%)
		HECTc	642..974	CDD:214523	116/341 (34%)
nedd4a	NP_001029358.1	C2_NEDD4_NEDD4L	22..153	CDD:175999
		WW	194..223	CDD:366073
		WW	349..378	CDD:366073
		WW	435..465	CDD:238122
		HECTc	577..906	CDD:214523	117/352 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000