DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG4238 and HACE1

DIOPT Version :9

Sequence 1:NP_001259896.1 Gene:CG4238 / 33377 FlyBaseID:FBgn0031384 Length:977 Species:Drosophila melanogaster
Sequence 2:NP_065822.2 Gene:HACE1 / 57531 HGNCID:21033 Length:909 Species:Homo sapiens


Alignment Length:522 Identity:158/522 - (30%)
Similarity:247/522 - (47%) Gaps:68/522 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly   488 GVSKNKPRKVLCYVGPKQNSLIFQVTIKEMILKFIPKRIATFRLCPSTKFHFLPQLVSQLHGPVF 552
            |..::||..:   .|.::.|...|..| .|....:...|..|.:|.|.      |:...:..|.|
Human   422 GTRESKPDAL---AGRQEASADCQDVI-SMTANRLSAVIQAFYMCCSC------QMPPGMTSPRF 476

  Fly   553 IIDDGAQPKIELASKDRN--IIAATFTHFLLK---------NIGGSETFKDKQDFFYHEVRKFHA 606
            |.......::.....:||  ||...| ||||:         :|..::.|||:.::||..:   |:
Human   477 IEFVCKHDEVLKCFVNRNPKIIFDHF-HFLLECPELMSRFMHIIKAQPFKDRCEWFYEHL---HS 537

  Fly   607 SY---------YHEKMALKVQREKILESSMKAVKGFSVSDWCGNFEVTFQGEQGIDWGGLRREWF 662
            ..         .:|...|.|.|:.|..||.:.|...:.:.......|.|.||:|:. .|:.||||
Human   538 GQPDSDMVHRPVNENDILLVHRDSIFRSSCEVVSKANCAKLKQGIAVRFHGEEGMG-QGVVREWF 601

  Fly   663 ELVCSALFDARGGLF------CTFHDKHQALVHPNPTRPAHLKLKHFEFAGKMVGKCLFESALGG 721
            :::.:.:.:....||      .||.....:.|:|:       .|.:|.|||:::|..|       
Human   602 DILSNEIVNPDYALFTQSADGTTFQPNSNSYVNPD-------HLNYFRFAGQILGLAL------- 652

  Fly   722 TYRQLVRARFSRSFLAQLIGLRVHYKYFEQDDPDLYLSKIKYILDTDLDATDTLELYFVEEMYDS 786
            .:||||...|:|||...::|:.|:|:.....||: |...:::|||.|:.... |||.|..|  ..
Human   653 NHRQLVNIYFTRSFYKHILGIPVNYQDVASIDPE-YAKNLQWILDNDISDLG-LELTFSVE--TD 713

  Fly   787 SSGQLSKTIELIPNGAKTRVTNATKNQYLDALAQQRLCNNVKDEVDSFLKGLNSIIPDNLLSIFD 851
            ..|.:.: :.|.|.|....||...|.:|:..:.:.|:...::.::::||:|.:..||.:|:.:||
Human   714 VFGAMEE-VPLKPGGGSILVTQNNKAEYVQLVTELRMTRAIQPQINAFLQGFHMFIPPSLIQLFD 777

  Fly   852 ENELELLMCGTGEYSISDF-KAHHIANGNSAEFRRVLAWFWAGVSNFSQTEMARLLQFTTGCSQL 915
            |.|||||:.|..|..:||: |.....:|...| ..|:.|||..|.:.:|.|...||||.||.|::
Human   778 EYELELLLSGMPEIDVSDWIKNTEYTSGYERE-DPVIQWFWEVVEDITQEERVLLLQFVTGSSRV 841

  Fly   916 PPGGFQELN-----PQFQITAAPTFGN-LPTAHTCFNQLCLPDYESYEQFEKSLLLAISEGSEGF 974
            |.|||..:.     ..|.|.|.|...| |||:.||.|.|.||:|.|.|..:..||:|:..||.|:
Human   842 PHGGFANIMGGSGLQNFTIAAVPYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVALHCGSYGY 906

  Fly   975 GM 976
            .|
Human   907 TM 908

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG4238NP_001259896.1 IG_FLMN 238..336 CDD:214720
Filamin 238..336 CDD:279024
HECTc 615..975 CDD:238033 124/372 (33%)
HECTc 642..974 CDD:214523 116/344 (34%)
HACE1NP_065822.2 Ank_2 <27..>283 CDD:330894
ANK 1 64..93
ANK repeat 66..95 CDD:293786
ANK 92..217 CDD:238125
ANK repeat 97..128 CDD:293786
ANK 2 97..126
ANK repeat 130..161 CDD:293786
ANK 3 130..159
ANK repeat 163..194 CDD:293786
ANK 4 163..192
ANK 5 196..226
ANK repeat 196..221 CDD:293786
ANK 6 228..257
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 398..433 3/13 (23%)
HECTc 554..903 CDD:238033 121/369 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D140374at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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