DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4238 and HECW2

DIOPT Version :9

Sequence 1:	NP_001259896.1	Gene:	CG4238 / 33377	FlyBaseID:	FBgn0031384	Length:	977	Species:	Drosophila melanogaster
Sequence 2:	XP_006712709.1	Gene:	HECW2 / 57520	HGNCID:	29853	Length:	1579	Species:	Homo sapiens

Alignment Length:	1044	Identity:	253/1044 - (24%)
Similarity:	404/1044 - (38%)	Gaps:	277/1044 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 SSLSSCGDPERLPELPPLDEQRLQRAALHLQ----------QKLILREWLKDHRLQHHYQRLLAV 131
            |||.|.    |.||.|....|..:..|...:          |:.:...           ..|..|
Human   668 SSLESA----RFPETPAFSSQEEEDGACAAEPTSSGPAEGSQESVCTA-----------GSLPVV 717

  Fly   132 EVASLEDVYWLEDSRASKI-------LGKDWQLWSGARQNLPTSKA------QLDALKAQLWSTV 183
            :|.|.||    |...|...       ||:.||    .|.:|..:.|      |.:....:...|.
Human   718 QVPSGED----EGPGAESATVPDQEELGEVWQ----RRGSLEGAAAAAESPPQEEGSAGEAQGTC 774

  Fly   184 VKSSQHQDAWTWGGMLVVSVSVAGLVTLAAMTQP--SLAPEARHSLLQYVTGKYLLPANCKVQWD 246
            ..::..::..|.|..             |...||  || |..|..:.:|......||.|
Human   775 EGATAQEEGATGGSQ-------------ANGHQPLRSL-PSVRQDVSRYQRVDEALPPN------ 819

  Fly   247 WKDPASVGGTMCFV-----VRFFQR-NGQPYP-ICDTDHFFVEVTEGTRKVVTISELGSSTDP-N 303
            |:......|.:.:|     ...:|| ...|.| :....:...::.:..|:..:|....::..| .
Human   820 WEARIDSHGRIFYVDHVNRTTTWQRPTAPPAPQVLQRSNSIQQMEQLNRRYQSIRRTMTNERPEE 884

  Fly   304 NANIAKVKFTVRTAGQYKISVLIGASHIAGSPFLR-SFLPGAIDARRSRFI---RPASTVICCAG 364
            |.|      .:..||:.      ...|.|.:.|.| :.||.:....|...:   .|...:|
Human   885 NTN------AIDGAGEE------ADFHQASADFRRENILPHSTSRSRITLLLQSPPVKFLI---- 933

  Fly   365 AP---TLMHIEP---RDEFGNSCL-------------FDQNQSDEALQGY-------QVAIYDLH 403
            :|   |::|..|   |....|:||             |::.|.:..|.|:       |:.:  ..
Human   934 SPEFFTVLHSNPSAYRMFTNNTCLKHMITKVRRDTHHFERYQHNRDLVGFLNMFANKQLEL--PR 996

  Fly   404 GVPVEKLQHAIVFAYDKVNSRVSVTALFPEPTCLRAVISYRDQQLPNGDFDIIVLSSSDTT--LV 466
            |..::.......|..|. |||.:               ::.|.:||        |.||..|  ||
Human   997 GWEMKHDHQGKAFFVDH-NSRTT---------------TFIDPRLP--------LQSSRPTSALV 1037

  Fly   467 HKNIASRKHNICYEAKLLSIFGVSKN----------KPRKVLCYVGPKQNSLIFQVTIKEMILKF 521
            |:...:|:.:       .|...|.::          :|......|...|...:..|...:.|:.|
Human  1038 HRQHLTRQRS-------HSAGEVGEDSRHAGPPVLPRPSSTFNTVSRPQYQDMVPVAYNDKIVAF 1095

  Fly   522 IPK----RIATFRLCPSTKFHFLPQLVSQLHGPVFIIDDGAQPKIELASK----------DRNII 572
            :.:    .|...|....|:.|.|.:.:.      ||..:|....:.|:|.          :..|:
Human  1096 LRQPNIFEILQERQPDLTRNHSLREKIQ------FIRTEGTPGLVRLSSDADLVMLLSLFEEEIM 1154

  Fly   573 AATFTHFLL----------------KNIGGSETFKD------KQDF------FYHEVRKFHASYY 609
            :....|.||                :|..|::....      |:||      ||   ||.....|
Human  1155 SYVPPHALLHPSYCQSPRGSPVSSPQNSPGTQRANARAPAPYKRDFEAKLRNFY---RKLETKGY 1216

  Fly   610 HE---KMALKVQREKILESSMKAVKGFSVSDWCGN-FEVTFQGEQGIDWGGLRREWFELVCSALF 670
            .:   |:.|.::|:.:||.:...:.|:|..|...| ..|||.||:|:|:.|..||:|.||...||
Human  1217 GQGPGKLKLIIRRDHLLEDAFNQIMGYSRKDLQRNKLYVTFVGEEGLDYSGPSREFFFLVSRELF 1281

  Fly   671 DARGGLF-CTFHDKHQALVHPNPTRPAHLKLKH--FEFAGKMVGKCLFESALGGTYRQLVRARFS 732
            :...||| .:.:|.:...:.|   ..|.:...|  |.|:|:::|..|.       ::.|:.|.|:
Human  1282 NPYYGLFEYSANDTYTVQISP---MSAFVDNHHEWFRFSGRILGLALI-------HQYLLDAFFT 1336

  Fly   733 RSFLAQLIGLRVHYKYFEQDDPDLYLSKIKYILDTDLDATDTLELYFV--EEMYDSSSGQLSKTI 795
            |.|...|:.:.......|..|.:.:.| ::::.|.|:.  |.|:|.|.  ||::    ||:::.
Human  1337 RPFYKALLRILCDLSDLEYLDEEFHQS-LQWMKDNDIH--DILDLTFTVNEEVF----GQITER- 1393

  Fly   796 ELIPNGAKTRVTNATKNQYLDALAQQRLCNNVKDEVDSFLKGLNSIIPDNLLSIFDENELELLMC 860
            ||.|.||...||...|.:|::.:.:.|:...|..:.:|.::|...::...|:|:||..||||::.
Human  1394 ELKPGGANIPVTEKNKKEYIERMVKWRIERGVVQQTESLVRGFYEVVDARLVSVFDARELELVIA 1458

  Fly   861 GTGEYSISDFKAHHIANGNSAEFRR-------VLAWFWAGVSNFSQTEMARLLQFTTGCSQLPPG 918
            ||.|..:||::       |:.|:|.       |:.||||.|..|:..:..|||||.||.|.:|..
Human  1459 GTAEIDLSDWR-------NNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLRLLQFVTGTSSIPYE 1516

  Fly   919 GFQEL----NPQ-------FQITAAPTFGNLPTAHTCFNQLCLPDYESYEQFEKSLLLAISEGSE 972
            ||..|    .|:       .:|||      ||.||||||:|.||.|.|:....:.||.|:.|.|.
Human  1517 GFASLRGSNGPRRFCVEKWGKITA------LPRAHTCFNRLDLPPYPSFSMLYEKLLTAVEETST 1575

  Fly   973 GFGM 976
             ||:
Human  1576 -FGL 1578

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4238	NP_001259896.1	IG_FLMN	238..336	CDD:214720	18/105 (17%)
		Filamin	238..336	CDD:279024	18/105 (17%)
		HECTc	615..975	CDD:238033	124/383 (32%)
		HECTc	642..974	CDD:214523	116/354 (33%)
HECW2	XP_006712709.1	HECW_N	45..164	CDD:318711
		C2_NEDL1-like	185..321	CDD:176073
		NESP55	<471..638	CDD:115071
		PHA03169	591..>801	CDD:223003	35/169 (21%)
		WW	816..845	CDD:306827	7/34 (21%)
		WW	994..1023	CDD:306827	6/46 (13%)
		HECTc	1223..1577	CDD:238033	124/385 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810