DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4238 and plekha7a

DIOPT Version :9

Sequence 1:	NP_001259896.1	Gene:	CG4238 / 33377	FlyBaseID:	FBgn0031384	Length:	977	Species:	Drosophila melanogaster
Sequence 2:	NP_001129715.1	Gene:	plekha7a / 571486	ZFINID:	ZDB-GENE-050419-75	Length:	1197	Species:	Danio rerio

Alignment Length:	241	Identity:	49/241 - (20%)
Similarity:	86/241 - (35%)	Gaps:	75/241 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 KGRP--PDHATRFDISMLVSHINVGGVMHAATGGKTFPTLKVKLCFGESMGISSLSSCGDPERLP 89
            ||||  |......|:.:.:|.:        ....|....|:.:|        |.|..  |.::|.
Zfish   653 KGRPAKPVKVAESDVDVTLSRL--------CEQDKILQELEFRL--------SGLKD--DKDKLE 699

  Fly    90 ELPPLDEQRLQRAALHLQQKLILREWLKDHRLQH-----HYQRLLAVEVASLE-DVYWLEDSRAS 148
            .:..:..|::              |..|| :..|     :.||||..::..:. |:     ||.|
Zfish   700 SVLDVSHQQM--------------EQYKD-QPSHTDKIAYQQRLLQEDLVHIRADI-----SRVS 744

  Fly   149 KILGKDWQLWSGARQN-------------LPTSKAQLDALKAQLWSTVVKSSQHQDAWTWGGMLV 200
            ..:.:.|..:||..|:             |.||..:.:.||.:||       :.:|..|.    :
Zfish   745 TEMERAWDDYSGMEQSVEQLRDVLQTQMTLCTSPQEKNQLKRELW-------RMEDVMTG----L 798

  Fly   201 VSVSVAGLVTLAAMTQP--SLAPEARHSLLQYVTGKYLLPANCKVQ 244
            .|......:|:.::..|  .|.|....|.   |..:.:.|:..:|:
Zfish   799 SSTKETFKITVDSVKNPERKLVPSVIEST---VPSRCMTPSAAEVR 841

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4238	NP_001259896.1	IG_FLMN	238..336	CDD:214720	2/7 (29%)
		Filamin	238..336	CDD:279024	2/7 (29%)
		HECTc	615..975	CDD:238033
		HECTc	642..974	CDD:214523
plekha7a	NP_001129715.1	WW	55..84	CDD:278809
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	98..148
		PH_PEPP1_2_3	153..256	CDD:270068
		PH	159..255	CDD:278594
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	348..384
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	423..467
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	508..577
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	830..928		2/12 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1032..1064
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900