Protein Alignment CG4238 and wwc3

DIOPT Version :9

• Sequence 1: NP_001259896.1
• Gene: CG4238 / 33377
• FlyBaseID: FBgn0031384
• Length: 977
• Species: Drosophila melanogaster
• Sequence 2: NP_001103940.1
• Gene: wwc3 / 566492
• ZFINID: ZDB-GENE-070209-229
• Length: 1148
• Species: Danio rerio
• Alignment Length: 600
• Identity: 112/600 - (18%)
• Similarity: 207/600 - (34%)
• Gaps: 171/600 - (28%)

  Fly   371 IEPRDEFGNSCLFDQNQSDEALQGYQVAIYDLH-GV----------PVEK------------LQH 412
            |:|||.......|.....||...|::| :||.. ||          .:|.            |:.
Zfish    44 IDPRDRITKPLTFADCVGDELPLGWEV-VYDQQVGVYYIDHINKTTQIENPRTQWRQEQERMLKE 107

  Fly   413 AIVFAYDKVNSRVSVTALFPEPTCLRAVISYRDQQLPNGDFDIIVLSSSDTTLVHKNIASRKHNI 477
            .:|.|.:.:|::..:..:..:    |..::.::.||.|      .|:..|    :::|.| .|:
Zfish   108 YLVVAQEALNAKKEMYQIKQQ----RLELAQQEMQLFN------QLTQDD----NRSITS-SHS- 156

  Fly   478 CYEAKLLSIFGVSKNKPRKVLCYVGPKQNSLIFQVTIKEMILKFIPKRIATFRLCPSTKFHFLPQ 542
                      |.|.|                          .|:.|.:|.....|...:...|.|
Zfish   157 ----------GSSSN--------------------------AKYDPDQIKAEIACRRERLSRLKQ 185

  Fly   543 LVSQLHGPVFIIDDGAQPKIELASKDRNIIAATFTHFLLKNIGGSETFKDKQDFFYHEVRKFHAS 607
            .::|:...:...:.|.:...|:..|    ::::.|::.|          |:....:.|:|..
Zfish   186 ELAQMRQELQYKEMGVETLQEIDRK----MSSSQTNYKL----------DEAQAIFSELRSI--- 233

  Fly   608 YYHEKMALKV---QREKILESSMKAVKGFSVSDWCGNF-EVTFQGEQGIDWGGLRREWFELVCSA 668
                |.|:..   :|:.:::|..|....|     |.:. |||...|...|...: :::.:..|..
Zfish   234 ----KKAISTGEKERQDLIQSLAKLTLNF-----CDSINEVTNNAESLADSCSV-QQYTDAGCQT 288

  Fly   669 LFDARGGLFCTFHDKHQALVHPNPTRPAHLKLK-HFEFAGKMVGKCLFESALGGTYRQLVRARFS 732
              |..|    .|..:..:|:      ...:||. .:|.|.|.:.....:.|...:.....||...
Zfish   289 --DLMG----EFGSQESSLL------ADRVKLSWQYEEAKKKMSSIQHQLAQLDSESWSGRAEAD 341

  Fly   733 RSF-LAQLIGLRVHYKYFEQDDPDLYLSKIKYILDTDLDATDTLELYFVEE---MYDSSSGQLSK 793
            |.: ..||:           .:.:..|.::. :|.....::||| |...||   :.|    ::.:
Zfish   342 RDWDCLQLL-----------REKETLLQELT-LLSQQQHSSDTL-LQLQEEKRRLQD----EVQR 389

  Fly   794 TIELIPNGAKTRVTNATKNQYLDALAQQRLCNNVKDEVDSFLKGLNSIIPDNLLSIFDENELELL 858
            .......||..|:....|...|  :.|......:...:.|.||.|::   .||
Zfish   390 AHSAQSQGANQRILLQEKRNVL--MRQLEEATRITTYLHSQLKSLSA---SNL------------ 437

  Fly   859 MCGTGEYSISDFKAHHIANGNSAEFRRVLAWFWAGVSNFSQTEMARLLQF--TTGCSQLPPGGFQ 921
                   ::|...    :.|:.|..|..||.....:|:.|.|::..|.|:  |.|.|.:....|:
Zfish   438 -------TVSSSS----SRGSLASSRGSLASSRGSLSSVSFTDIYGLPQYDRTEGSSDVLDPSFR 491

  Fly   922 ELNPQFQITAAPTFG 936
            .|.|....::...:|
Zfish   492 YLLPLESHSSGSAYG 506

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4238	NP_001259896.1	IG_FLMN	238..336	CDD:214720
		Filamin	238..336	CDD:279024
		HECTc	615..975	CDD:238033	64/332 (19%)
		HECTc	642..974	CDD:214523	59/302 (20%)
wwc3	NP_001103940.1	WW	17..46	CDD:278809	1/1 (100%)
		WW	64..93	CDD:278809	7/29 (24%)
		C2_Kibra	677..800	CDD:176062

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900